Conceptualising and prototyping a decision support system for safer urban unmanned aerial vehicle operations

Currently, there is limited discourse surrounding the safe operational planning of UAVs within complex multi-stakeholder urban environments. This paper conceptualises a methodology for prototyping a decision support system for urban UAV flight operations planning. The proposition is based on integrating urban 3-dimensional data with the physical factors of UAV flight operations. A simulated, holistic understanding of UAV usage in urban space emerges, enabling better informed decisions by planners around safe flight operations. The feasibility, applicability and benefits of the decision support system and associated policy implications for urban planners and UAV users are discussed scoping further development of this approach

Planning a Dublin–Belfast Economic Corridor: Networks, engagement and creating opportunities

Cross-border cooperation on the island of Ireland has a long history, if often a limited scope. The emergence of statutory North/South bodies after the Belfast/Good Friday Agreement of 1998 added a new dynamic. This paper argues that the further development of the Dublin–Belfast Economic Corridor will require key stakeholders to engage widely, not only with a private sector whose rationale will be greater levels of commercial activity along the Corridor but also with others who will bring additional agendas into discussion, including sustainability and quality of life. Political engagement will also be critical to ensure that the top-down support, in terms of investment and alignment with other policy priorities, is present. The framework for this collaboration is already in place, something that was absent in the 1990s

Planning a Dublin–Belfast Economic Corridor: Networks, engagement and creating opportunities

Cross-border cooperation on the island of Ireland has a long history, if often a limited scope. The emergence of statutory North/South bodies after the Belfast/Good Friday Agreement of 1998 added a new dynamic. This paper argues that the further development of the Dublin–Belfast Economic Corridor will require key stakeholders to engage widely, not only with a private sector whose rationale will be greater levels of commercial activity along the Corridor but also with others who will bring additional agendas into discussion, including sustainability and quality of life. Political engagement will also be critical to ensure that the top-down support, in terms of investment and alignment with other policy priorities, is present. The framework for this collaboration is already in place, something that was absent in the 1990s

Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males

Introduction The relationship of circulating levels of receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) with the expression of these molecules in bone has not been established. The objective of this study was to measure, in humans, the serum levels of RANKL and OPG, and the corresponding levels in bone of mRNA encoding these proteins. Methods Fasting blood samples were obtained on the day of surgery from patients presenting for hip replacement surgery for primary osteoarthritis (OA). Intraoperatively, samples of intertrochanteric trabecular bone were collected for analysis of OPG and RANKL mRNA, using real time RT-PCR. Samples were obtained from 40 patients (15 men with age range 50 to 79 years, and 25 women with age range 47 to 87 years). Serum total RANKL and free OPG levels were measured using ELISA. Results Serum OPG levels increased over the age range of this cohort. In the men RANKL mRNA levels were positively related to age, whereas serum RANKL levels were negatively related to age. Again, in the men serum RANKL levels were inversely related (r = -0.70, P = 0.007) to RANKL mRNA levels. Also in the male group, RANKL mRNA levels were associated with a number of indices of bone structure (bone volume fraction relative to bone tissue volume, specific surface of bone relative to bone tissue volume, and trabecular thickness), bone remodelling (eroded surface and osteoid surface), and biochemical markers of bone turnover (serum alkaline phosphatase and osteocalcin, and urinary deoxypyridinoline). Conclusion This is the first report to show a relationship between serum RANKL and the expression of RANKL mRNA in bone.David Findlay, Mellick Chehade, Helen Tsangari, Susan Neale, Shelley Hay, Blair Hopwood, Susan Pannach, Peter O'Loughlin and Nicola Fazzalar