335 research outputs found

    The nature of a broad line radio galaxy: Simultaneous RXTE and Chandra HETG observations of 3C 382

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    We present the results from simultaneous chandra and rxte observations of the X-ray bright Broad-Line Radio Galaxy (BLRG) 3C 382. The long (120 ks) exposure with chandra HETG allows a detailed study of the soft X-ray continuum and of the narrow component of the Fe Kalpha line. The rxte PCA data are used to put an upper limit on the broad line component and constrain the hard X-ray continuum. A strong soft excess below 1 keV is observed in the time-averaged HETG spectrum, which can be parameterized with a steep power law or a thermal model. The flux variability at low energies indicates that the origin of the soft excess cannot be entirely ascribed to the circumnuclear diffuse emission, detected by chandra on scales of 20-30 arcsec (22-33 kpc). A narrow (sigma<90 eV) Fe Kalpha line (with EW< 100 eV) is observed by the chandra HEG. Similar values for the line parameters are measured by the rxte PCA, suggesting that the contribution from a broad line component is negligible. The fact that the exposure is split into two observations taken three days apart allows us to investigate the spectral and temporal evolution of the source on different timescales. Significant flux variability associated with spectral changes is observed on timescales of hours and days. The spectral variability is similar to that observed in radio-quiet AGN ruling out a jet-dominated origin of the X-rays.Comment: 19 pages, 10 figures, 3 tables, accepted for publication in Ap

    Analysis of Dialogical Argumentation via Finite State Machines

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    Dialogical argumentation is an important cognitive activity by which agents exchange arguments and counterarguments as part of some process such as discussion, debate, persuasion and negotiation. Whilst numerous formal systems have been proposed, there is a lack of frameworks for implementing and evaluating these proposals. First-order executable logic has been proposed as a general framework for specifying and analysing dialogical argumentation. In this paper, we investigate how we can implement systems for dialogical argumentation using propositional executable logic. Our approach is to present and evaluate an algorithm that generates a finite state machine that reflects a propositional executable logic specification for a dialogical argumentation together with an initial state. We also consider how the finite state machines can be analysed, with the minimax strategy being used as an illustration of the kinds of empirical analysis that can be undertaken.Comment: 10 page

    The first endovascular repair of an acute type A dissection using an endograft designed for the ascending aorta

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    Endovascular repair has emerged as a potential alternative to emergency open surgical repair for type A dissection in selected patients, with isolated reports describing the results obtained with a range of devices designed originally for the descending aorta. We believe that we present the first reported repair of an acute ascending aortic dissection using an endovascular stent graft manufactured specifically for the ascending aorta

    Is there an optimum speed for economical running?

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    The influence of running speed and sex on running economy is unclear and may have been confounded by measurements of oxygen cost that do not account for known differences in substrate metabolism, across a limited range of speeds, and differences in performance standard. Therefore, this study assessed the energy cost of running over a wide range of speeds in high-level and recreational runners to investigate the effect of speed (considered in absolute and relative terms) and sex (males vs. females of equivalent performance standard) on running economy. 92 healthy runners (high-level males, n=14; high-level females, n=10; recreational males, n=35; recreational females, n=33) completed a discontinuous incremental treadmill test for the determination of the energy cost (kcal·kg 1·km-1) of submaximal running, speed at lactate turnpoint (sLTP) and the maximal rate of oxygen uptake (V̇O2max). There were no sex specific differences in the energy cost of running for the recreational or high-level runners when compared at absolute or relative running speeds (P>0.05). The absolute and relative speed-energy cost relationships for the high-level runners demonstrated a curvilinear inverted “u shape” with a nadir reflecting the most economical speed at 13 km.h-1 or 70% sLTP. The high-level runners were more economical than the recreational runners at all absolute and relative running speeds (P<0.05). These findings demonstrate that there is an optimal speed for economical running; there is no sex-specific difference; and, high-level endurance runners exhibit a better running economy than recreational endurance runners

    Road cycle TT performance: Relationship to the power-duration model and association with FTP

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    Purpose: To determine the accuracy of critical power (CP) and Wʹ (the curvature constant of the power-duration relationship) derived from self-paced time-trial (TT) prediction trials using mobile power meters to predict 16.1 km road cycling TT performance. This study also aimed to test the agreement between functional threshold power (FTP) and CP. Methods: Twelve competitive male cyclists completed an incremental test to exhaustion, a 16.1-km road TT, an FTP test, and 4–5 self-paced TT bouts on a stationary bike within the lab, using mobile power meters. Results: CP and Wʹ derived from the power-duration relationship closely predicted TT performance. The 16.1 km road TT completion time (26.7 ± 2.2 min) was significantly correlated with the predicted time-to-completion (27.5 ± 3.3 min, r= 0.89, P0.05); however, the limits of agreement between CP and FTP were 30 to -36 W. Discussion: The findings of this study indicate that CP and Wʹ determined using mobile power meters during maximal, self-paced TT prediction trials can be used to accurately predict 16.1-km cycling performance, supporting the application of the CP and Wʹ for performance prediction. However, whilst we demonstrated that the FTP was not significantly different from CP, the limits of agreement were too large to consider FTP and CP interchangeable

    Physiological deterioration in the Emergency Department: the SNAP40-ED study

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    Continuous novel ambulatory monitoring may detect deterioration in Emergency Department (ED) patients more rapidly, prompting treatment and preventing adverse events. Single-centre, open-label, prospective, observational cohort study recruiting high/medium acuity (Manchester triage category 2 and 3) participants, aged over 16 years, presenting to ED. Participants were fitted with a novel wearable monitoring device alongside standard clinical care (wired monitoring and/or manual clinical staff vital sign recording) and observed for up to 4 hours in the ED. Primary outcome was time to detection of deterioration. Two-hundred and fifty (250) patients were enrolled. In 82 patients (32.8%) with standard monitoring (wired monitoring and/or manual clinical staff vital sign recording), deterioration in at least one vital sign was noted during their four-hour ED stay. Overall, the novel device detected deterioration a median of 34 minutes earlier than wired monitoring (Q1, Q3 67,194; n=73, mean difference 39.48, p<0.0001). The novel device detected deterioration a median of 24 minutes (Q1, Q3 2,43; n=42) earlier than wired monitoring and 65 minutes (Q1, Q3 28,114; n=31) earlier than manual vital signs. Deterioration in physiology was common in ED patients. ED staff spent a significant amount of time performing observations and responding to alarms, with many not escalated. The novel device detected deterioration significantly earlier than standard care

    The effects of β-alanine supplementation on muscle pH and the power-duration relationship during high-intensity exercise

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    Purpose: To investigate the influence of β-alanine (BA) supplementation on muscle carnosine content, muscle pH and the power-duration relationship (i.e., critical power and W′). Methods: In a double-blind, randomized, placebo-controlled study, 20 recreationally-active males (22 ± 3 y, VO˙2peak 3.73 ± 0.44 L·min−1) ingested either BA (6.4 g/d for 28 d) or placebo (PL) (6.4 g/d) for 28 d. Subjects completed an incremental test and two 3-min all-out tests separated by 1-min on a cycle ergometer pre- and post-supplementation. Muscle pH was assessed using 31P-magnetic resonance spectroscopy (MRS) during incremental (INC KEE) and intermittent knee-extension exercise (INT KEE). Muscle carnosine content was determined using 1H-MRS. Results: There were no differences in the change in muscle carnosine content from pre- to post-intervention (PL: 1 ± 16% vs. BA: −4 ± 25%) or in muscle pH during INC KEE or INT KEE (P > 0.05) between PL and BA, but blood pH (PL: −0.06 ± 0.10 vs. BA: 0.09 ± 0.13) during the incremental test was elevated post-supplementation in the BA group only (P < 0.05). The changes from pre- to post-supplementation in critical power (PL: −8 ± 18 W vs. BA: −6 ± 17 W) and W′ (PL: 1.8 ± 3.3 kJ vs. BA: 1.5 ± 1.7 kJ) were not different between groups. No relationships were detected between muscle carnosine content and indices of exercise performance. Conclusions: BA supplementation had no significant effect on muscle carnosine content and no influence on intramuscular pH during incremental or high-intensity intermittent knee-extension exercise. The small increase in blood pH following BA supplementation was not sufficient to significantly alter the power-duration relationship or exercise performance
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