404 research outputs found

    Elucidation of Anticancer Activity of Andrographis Paniculata and Its Role in the Expression of E-Cadherin and P53 in Prostate Cancer

    Get PDF
    Plant-derived compounds act as a prevention within the development of many anti-cancer agents. Natural drugs have less toxicity than the commercially available drugs. So now a days they are widely used for curing many diseases including cancer. Among cancer especially prostrate cancer has been responsible for drastic mortality rate in males. Cancer is mainly studied by genetics and epigenetic modification. Mostly drugs are used to restore the function of tumor supressor genes..In our study, we have carried out an effort towards checking the effect of Kalmegh extracts towards restoring the expression of tumor suppressor gene, E-cadherin (CDH1) and p-53 in PC-3 cell line. HDACs are the epigenetic manipulators which plays an important role in the gene silencing which leads to the initiation of cancer and rapid proliferation.. There are several commercially available HDAC inhibitors but they are highly toxic in nature. So, here we are using the natural drugs from phytochemicals to reduce the toxicity level. As in cancer cells the tumor suppressor genes E-cadherin and P-53 shows the down regulation but while treating with the leaf extract of Andrographis paniculata the genes show up-regulation

    Implementation of online temperature controller based on LabVIEW

    Get PDF
    LabVIEW (Laboratory Virtual Instrumentation Engineering Workbench) is the software which gives virtual existence of hardware, reduces its cost and hence termed as Virtual Instrumentation. This thesis presents the implementation of ON/OFF and PID controller for controlling the temperature of a heating element inside a wooden box with the help of LabVIEW. In this software, DataSocket Protocol and Transmission Control Protocol (TCP) are used for developing an online transmission process between client and server. Client has control over the set point and Server has control over the temperature. With the help of internet protocol, client provides the value of set point according to which the control actions are taken by the server. The paper also includes discussions regarding the advantages and disadvantages of TCP/IP. Written communication in LabVIEW refers to communication via internet where the user can write messages to another user. Generally written communication is not found in any programming related software but LabVIEW makes this possible using internet protocol. This helps in easy and fast transmission of data in form of messages between the client and server PC(s). After the transmission process gets over, the transmitted data is used for implementing PID controller. The various responses in PID controller are obtained by varying the tuning parameters. The responses are with respect to three conditions in the controller. On studying the response curves, parameters like setting time, rise time and maximum overshoot are obtained. A comparison table is obtained for these parameters and helps in deciding to choose the values for tuning parameters of the controller

    Water resource management - crisis in 21st century

    Get PDF
    Water resource management - crisis in 21st centur

    Performance analysis of Dynamic MANET Ondemand (DYMO) Routing protocol

    Get PDF
    Routing in a MANET is challenging because of the dynamic topology and the lack of an existing fixed infrastructure. In such a scenario a mobile host can act as both a host and a router forwarding packets for other mobile nodes in the network. Routing protocols used in mobile ad hoc networks (MANET) must adapt to frequent or continual changes of topology, while simultaneously limiting the impact of tracking these changes on wireless resources. The DYMO protocol intended for the use by mobile nodes in wireless multihop ad hoc networks. It can adapt to the changing network topology and determine unicast routes between nodes within the network. This paper presents a comprehensive summarization and a comparative study of the Dynamic MANET On-demand (DYMO) protocol for MANET and simulation analysis of existing protocols DSR and AODV and comparison among them under varying number of nodes. Comparative study shows that DYMO is only a good choice if the nodes are mobile and wireless multihop. We have compared the performance of DSR and AODV with DYMO protocol by taking some performance metrics. Result shows that DYMO simulation provides better performance than DSR when compared in a given network topology with respect to throughput, packet loss, delay, packet delivery ratio, normalized routing load

    Bacteria Foraging Algorithm for Metamaterial Design and Optimization

    Get PDF
    Soft computing techniques are emerging as highly efficient global optimization techniques in the field of electromagnetics. These techniques along with the EM software have proved their efficiency in antenna engineering, wireless communication, absorber design and a few in the field of metamaterial structural analysis. Bacteria foraging algorithm, although has been used recently in controls, is still new to the field of metamaterial science and technology. In this paper, bacteria foraging algorithm (BFA) is used for design optimization of a double ring circular split ring resonator. Equivalent circuit analysis is used the EM tool for analysis of the CSRR. The aim of bacteria foraging algorithm is the estimation of structural parameters of the CSRR at a desired frequency range. Further the developed algorithm is proved through extraction of parameters of the optimized metamaterial structure. A comparative study with other soft computing techniques w.r.t. accuracy and computational time is provided

    Investigation on Fires in Coal Mines and Approach for Prevention – Case Study

    Get PDF
    Coal absorbs oxygen even at lower temperatures than the ambient temperature and they start heating up. This heating without any external source of supply of heat generally leads to due to auto-oxidation, also called spontaneous heating of coal.Due to auto-oxidation, we are faced with many dangerous problems. Therefore the assessment of this problem has become necessary and hence we are trying to calculate and predict how susceptible or prone any coal might be towards spontaneous heating before its use in any industry. As a Mining Engineer some steps towards the prevention were noted from the observations of earlier investigators and some suggestions are made from our findings which may reduce the possibilities of tendencies towards auto-oxidation and also to find some suitable way to minimize the threat caused due to this spontaneous heating

    Study of Zirconia-Mullite system: Effect of SrO addition with alumina content variation

    Get PDF
    Mullite-zirconia systems have encouraged developing a refractory composite with thermomechanical properties, which can be widely used in glass and steel industries. Numerous methods have been employed and researches have been carried out in developing such a composite whose properties can be enhanced with the effect of additives. In this project work, Strontium oxide has been used an additive and also the alumina content has been varied to study the densification behavior of the zirconia-mullite system. 2, 4, and 6% SrO were added to the stoichiometric and non-stoichiometric batches (with deficient and excess alumina). Then the samples were fired at 1500-1600 oC and various characterizations were conducted. The bulk density, dimensional density, apparen porosity, and volume shrinkage tests were performed to interpret the nature of the composite with addition of SrO. Also X-ray diffraction analysis was carried out to determine the phases and analyze the phase compositions in various samples

    Topographical Automation of MANET using Reactive Routing Protocols

    Get PDF
    Wireless mobile ad-hoc networks (MANET) are characterized as infrastructure less networks. Topologies are formed with movement of regular nodes which has multi radio links and these regular nodes under demand behaves as backbone node (router) to forward packets across the network. These networks suffer frequent topology changes due to the dynamic stochastic process behavior of incoming nodes. Mobile ad-hoc networks lack load balancing that causes unnecessary packet loss and route break up in real-time data transmission. Area of operation, interference, and communication link range and path loss are the factors to affect the throughput of MANET. In this paper we evaluated the performance of AODV and DSR routing protocols which are enhanced by an Automation Topography, In our proposed Topographical Automation the location of incoming nodes are completely random and those will be confined themselves within a certain communication range such that the throughput is enhanced to meet better QoS level. As location of the nodes are system defined and quite automatic, nodes before being forwarded with the full assurance of successful session flows. It is often advantageous to position stable and capable relay nodes, including unmanned ground vehicles (UGVs) or unmanned aerial vehicles (UAVs), and unmanned under sea vehicles (UUVs) used by Defense to save cost as well as life

    A study of color, material and finish designs using a culture-oriented approach and its impact on product recognition

    Get PDF
    This research study focuses on a culture-oriented approach to Color, Material, and Finish (CMF) design for products and its impact on product recognition. The study identifies the CMF elements of a traditional Maharashtrian craft and translates them onto a household product (a bowl). The research investigates the recognition value, viewer's perceptions, and preferences for the new proposed CMF designs of bowls that are inspired by Maharashtrian Khana sarees. A mixed-methods approach is taken combining qualitative and quantitative methods. Study results indicate that a cultural approach to CMF design allows designers to present more recognizable products in the market. CMF designers need to target a specific user group and cultural context to fulfil the user’s aesthetic needs and desires

    Meeting IMT 2030 Performance Targets: The Potential of OTFDM Waveform and Structural MIMO Technologies

    Full text link
    The white paper focuses on several candidate technologies that could play a crucial role in the development of 6G systems. Two of the key technologies explored in detail are Orthogonal Time Frequency Division Multiplexing (OTFDM) waveform and Structural MIMO (S-MIMO)
    corecore