Impact of planting density on wheat crop grown under different tree species in tarai agroforestry system of central himalaya, India

A field trial based Agroforestry system was established at Pantnagar during Rabi season 2012-13 for predicting the effect of spacing on growth and yield of wheat (Triticum aestivum L.) under Eucalyptus camaldulensis and Melia azedarach. The experiment was carried out in split-plot design consisting of two tree species in main plot, viz, Eucalyptus camaldulensis and Melia azedarch and four spacing treatments in sub-plot viz, 3.0m×1.0m, 3.0m×1.5m, 3.0m×2.0m and 3.0m×2.5m with three replications. The wheat crop variety“UP-2338” was sown on December 06, 2012 and harvested on April 27, 2013. Among the tree species, the maximum (15.1 q /ha) and significantly higher grain yield with 21.8% increment was recorded under Melia as compare to Eucalyptus. Whereas, among the different spacings, the wheat growth in terms of dry biomass at 120 DAS (495.4/m2 ), yield attributes and yield in terms of grain (16.0 q/ha), straw (29.4 q/ha) and biological yield (45.4 q/ha) under Melia was significantly higher at 3 × 2.5 m spacing as compared to other planting density. The correlation coefficient (r) studies exhibited that wheat growth and yield attributing characteristics shows significantly (p<0.05) high degree (r=0.75 to 1) positive correlation with each other. The investigation was done to find out the proper planting density for intercropping of wheat with tree species without comprising the wheat growth and enhancing its sustainability

Comparison of wheat yield and soil properties under open and poplar based agroforestry system

Field experiment was conducted during the Rabi season of 2013-14 on an established plantation at old site of Agroforestry Research Centre, Patharchatta of G.B. Pant University of Agriculture and Technology, Pantna-gar, District Udham Singh Nagar, Uttarakhand, India to evaluate the effect of poplar based agroforestry system and open system (without poplar) on yield of different wheat varieties and soil physico-chemical properties.The experi-ment was laid out in randomized block design with 4 treatments and each replicated thrice under both the growing conditions. The crop treatments are wheat varieties viz. UP-2572, PBW-550, DBW-711 and PBW-373. The highest grain yield of all the wheat varieties was obtained under open farming system. Highest grain yield of wheat was rec-orded in UP-2572 (45.3 q/ha) under open farming system. Agroforestry is proven land use system for vertically en-hancing soil health against unsuitable weather condition. The distribution of soil properties was detected from the depth 0-15 cm in poplar based agroforestry system and as well as in open system. During the experiment it was found that agroforestry add more nutrients to the soil compared to open system i.e. highest pH (7.9), EC (0.43 dSm-1), available soil nitrogen (253.48 kg/ha), potassium (219.63 kg/ha) were achieved with UP-2572 while organic car-bon (1.07%) and available soil phosphorus (22.72 kg/ha) were attained with DBW-711

HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR

In normoxia, hypoxia-inducible transcription factors (HIFs) are rapidly degraded within the cytoplasm as a consequence of their prolyl hydroxylation by oxygen-dependent prolyl hydroxylase domain (PHD) enzymes. We have previously shown that hematopoietic stem and progenitor cells (HSPCs) require HIF-1 for effective mobilization in response to granulocyte colony-stimulating factor (G-CSF) and CXCR4 antagonist AMD3100/plerixafor. Conversely, HIF PHD inhibitors that stabilize HIF-1 protein in vivo enhance HSPC mobilization in response to G-CSF or AMD3100 in a cell-intrinsic manner. We now show that extrinsic mechanisms involving vascular endothelial growth factor receptor-2 (VEGFR2), via bone marrow (BM) endothelial cells, are also at play. PTK787/vatalanib, a tyrosine kinase inhibitor selective for VEGFR1 and VEGFR2, and neutralizing anti-VEGFR2 monoclonal antibody DC101 blocked enhancement of HSPC mobilization by FG-4497. VEGFR2 was absent on mesenchymal and hematopoietic cells and was detected only in Sca1 endothelial cells in the BM. We propose that HIF PHD inhibitor FG-4497 enhances HSPC mobilization by stabilizing HIF-1α in HSPCs as previously demonstrated, as well as by activating VEGFR2 signaling in BM endothelial cells, which facilitates HSPC egress from the BM into the circulation

Extensions of P-property, R0-property and semidefinite linear complementarity problems

In this manuscript, we present some new results for the semidefinite linear complementarity problem, in the context of three notions for linear transformations, viz., pseudo w-P property, pseudo Jordan w-P property and pseudo SSM property. Interconnections with the P#-property (proposed recently in the literature) is presented. We also study the R#-property of a linear transformation, extending the rather well known notion of an R0-matrix. In particular, results are presented for the Lyapunov, Stein, and the multiplicative transformation

Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds

Numerous dietary compounds, ubiquitous in fruits, vegetables and spices have been isolated and evaluated during recent years for their therapeutic potential. These compounds include flavonoid and non-flavonoid polyphenols, which describe beneficial effects against a variety of ailments. The notion that these plant products have health promoting effects emerged because their intake was related to a reduced incidence of cancer, cardiovascular, neurological, respiratory, and age-related diseases. Exposure of the body to a stressful environment challenges cell survival and increases the risk of chronic disease developing. The polyphenols afford protection against various stress-induced toxicities through modulating intercellular cascades which inhibit inflammatory molecule synthesis, the formation of free radicals, nuclear damage and induce antioxidant enzyme expression. These responses have the potential to increase life expectancy. The present review article focuses on curcumin, resveratrol, and flavonoids and seeks to summarize their anti-inflammatory, cytoprotective and DNA-protective properties

Impact of planting density on wheat crop grown under different tree species in tarai agroforestry system of central himalaya, India

A field trial based Agroforestry system was established at Pantnagar during Rabi season 2012-13 for predicting the effect of spacing on growth and yield of wheat (Triticum aestivum L.) under Eucalyptus camaldulensis and Melia azedarach. The experiment was carried out in split-plot design consisting of two tree species in main plot, viz, Eucalyptus camaldulensis and Melia azedarch and four spacing treatments in sub-plot viz, 3.0m×1.0m, 3.0m×1.5m, 3.0m×2.0m and 3.0m×2.5m with three replications. The wheat crop variety“UP-2338” was sown on December 06, 2012 and harvested on April 27, 2013. Among the tree species, the maximum (15.1 q /ha) and significantly higher grain yield with 21.8% increment was recorded under Melia as compare to Eucalyptus. Whereas, among the different spacings, the wheat growth in terms of dry biomass at 120 DAS (495.4/m2 ), yield attributes and yield in terms of grain (16.0 q/ha), straw (29.4 q/ha) and biological yield (45.4 q/ha) under Melia was significantly higher at 3 × 2.5 m spacing as compared to other planting density. The correlation coefficient (r) studies exhibited that wheat growth and yield attributing characteristics shows significantly (p<0.05) high degree (r=0.75 to 1) positive correlation with each other. The investigation was done to find out the proper planting density for intercropping of wheat with tree species without comprising the wheat growth and enhancing its sustainability

Curcumin enhances non-inflammatory phagocytic activity of RAW264.7 cells

Present study was performed to assess the effect of curcumin treatment on macrophage functions using RAW264.7 cells, a murine macrophage cell line. Phagocytic activity of RAW264.7 cells was enhanced by the treatment with curcumin for 48 h while the nitric oxide synthesis from RAW264.7 cells following lipopolysaccharide exposure was blocked. The incubation of RAW264.7 cells with curcumin dose-dependently inhibited the stimulatory responses of macrophage triggered by lipopolysaccharide; the enhanced secretion of inflammatory cytokines such as TNF-α and IL-1β and the up-regulated expression of surface antigens like CD14 and CD40. Curcumin alone, however, was able to increase the basal level of TNF-α secretion and elevated markedly the expression of CD14 and slightly CD40. The marked enhancement of both phagocytic activity and CD14 was detectable as early as 75 min after curcumin treatment which is the minimum time period required for the phagocytosis and CD14 measurement, suggesting a signaling pathway distinct from that triggered by apoptotic cells. In conclusion, this study elucidates that curcumin treatment enhances the phagocytic activity with blocking nitric oxide synthesis, a scavenger function of macrophages in non-inflammatory condition. In addition, this enhancement of phagocytic activity is triggered directly by the signals from curcumin itself not by apoptotic cells

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling

Macrophages play a crucial role in the maintenance and resolution of inflammation and express a number of pro- and anti-inflammatory molecules in response to stressors. Among them, the complement receptor 5a (C5aR) plays an integral role in the development of inflammatory disorders. Biliverdin and bilirubin, products of heme catabolism, exert anti-inflammatory effects and inhibit complement activation. Here, we define the effects of biliverdin on C5aR expression in macrophages and the roles of Akt and mammalian target of rapamycin (mTOR) in these responses. Biliverdin administration inhibited lipopolysaccharide (LPS)-induced C5aR expression (without altering basal expression), an effect partially blocked by rapamycin, an inhibitor of mTOR signaling. Biliverdin also reduced LPS-dependent expression of the pro-inflammatory cytokines TNF-alpha and IL-6. Collectively, these data indicate that biliverdin regulates LPS-mediated expression of C5aR via the mTOR pathway, revealing an additional mechanism underlying biliverdin's anti-inflammatory effects