The Infocus Hard X-ray Telescope: Pixellated CZT Detector/Shield Performance and Flight Results

The CZT detector on the Infocus hard X-ray telescope is a pixellated solid-state device capable of imaging spectroscopy by measuring the position and energy of each incoming photon. The detector sits at the focal point of an 8m focal length multilayered grazing incidence X-ray mirror which has significant effective area between 20--40 keV. The detector has an energy resolution of 4.0keV at 32keV, and the Infocus telescope has an angular resolution of 2.2 arcminute and a field of view of about 10 arcminutes. Infocus flew on a balloon mission in July 2001 and observed Cygnus X-1. We present results from laboratory testing of the detector to measure the uniformity of response across the detector, to determine the spectral resolution, and to perform a simple noise decomposition. We also present a hard X-ray spectrum and image of Cygnus X-1, and measurements of the hard X-ray CZT background obtained with the SWIN detector on Infocus.Comment: To appear in the proceedings of the SPIE conference "Astronomical Telescopes and Instrumentation", #4851-116, Kona, Hawaii, Aug. 22-28, 2002. 12 pages, 9 figure

What have we learned from antiproton proton scattering?

From recent charge exchange measurements in the extreme forward direction, an independent and precise determination of the pion nucleon coupling constant is possible. This determination has reopened the debate on the value of this fundamental coupling constant of nuclear physics. Precise measurements of charge exchange observables at forward angles below 900 MeV/c would also give a better understanding of the long range part of the two-pion exchange potential. For example, the confirmation of the coherence of the tensor forces from the pion exchange and the isovector two-pion exchange would be very valuable. With the present data first attempts at an \NbarN partial wave analysis have been made where, as in nucleon nucleon scattering, the antinucleon nucleon high J partial waves are mainly given by one-pion exchange. Finally a recent \pbarp atomic cascade calculation and the fraction of P-state annihilation in gas targets is commented on.Comment: 10 pages, Latex, to be published in Nucl. Phy

Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution

In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho-GTPases regulate mitochondrial transport along microtubules by linking mitochondria to kinesin and dynein motors. By generating Miro1/2 double-knockout mouse embryos and single- and double-knockout embryonic fibroblasts, we demonstrate the essential and non-redundant roles of Miro proteins for embryonic development and subcellular mitochondrial distribution. Unexpectedly, the TRAK1 and TRAK2 motor protein adaptors can still localise to the outer mitochondrial membrane to drive anterograde mitochondrial motility in Miro1/2 double-knockout cells. In contrast, we show that TRAK2-mediated retrograde mitochondrial transport is Miro1-dependent. Interestingly, we find that Miro is critical for recruiting and stabilising the mitochondrial myosin Myo19 on the mitochondria for coupling mitochondria to the actin cytoskeleton. Moreover, Miro depletion during PINK1/Parkin-dependent mitophagy can also drive a loss of mitochondrial Myo19 upon mitochondrial damage. Finally, aberrant positioning of mitochondria in Miro1/2 double-knockout cells leads to disruption of correct mitochondrial segregation during mitosis. Thus, Miro proteins can fine-tune actin- and tubulin-dependent mitochondrial motility and positioning, to regulate key cellular functions such as cell proliferation

On the pion-nucleon coupling constant

In view of persisting misunderstanding about the determination of the pion-nucleon coupling constants in the Nijmegen multienergy partial-wave analyses of pp, np, and pbar-p scattering data, we present additional information which may clarify several points of discussion. We comment on several recent papers addressing the issue of the pion-nucleon coupling constant and criticizing the Nijmegen analyses.Comment: 19 pages, Nijmegen preprint THEF-NYM-92-0

ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity

Mutations in the RNA-binding protein (RBP) FUS have been genetically associated with the motoneuron disease amyotrophic lateral sclerosis (ALS). Using both human induced pluripotent stem cells and mouse models, we found that FUS-ALS causative mutations affect the activity of two relevant RBPs with important roles in neuronal RNA metabolism: HuD/ELAVL4 and FMRP. Mechanistically, mutant FUS leads to upregulation of HuD protein levels through competition with FMRP for HuD mRNA 3’UTR binding. In turn, increased HuD levels overly stabilize the transcript levels of its targets, NRN1 and GAP43. As a consequence, mutant FUS motoneurons show increased axon branching and growth upon injury, which could be rescued by dampening NRN1 levels. Since similar phenotypes have been previously described in SOD1 and TDP-43 mutant models, increased axonal growth and branching might represent broad early events in the pathogenesis of ALS

Combined Description of N‾N\bf{\overline{N}N} Scattering and Annihilation With A Hadronic Model

A model for the nucleon-antinucleon interaction is presented which is based on meson-baryon dynamics. The elastic part is the $G$-parity transform of the Bonn $NN$ potential. Annihilation into two mesons is described in terms of microscopic baryon-exchange processes including all possible combinations of $\pi,\eta,\rho,\omega,a_0,f_0,a_1,f_1,a_2,f_2,K,K^*$. The remaining annihilation part is taken into account by a phenomenological energy- and state independent optical potential of Gaussian form. The model enables a simultaneous description of nucleon-antinucleon scattering and annihilation phenomena with fair quality.Comment: revised version, REVTEX, 9 pages, 10 figures available from this URL ftp://ikp113.ikp.kfa-juelich.de/pub/kph140/nucl-th.9411014.u

The high voltage system for the novel MPGD-based photon detectors of COMPASS RICH-1

The architecture of the novel MPGD-based photon detectors of COMPASS RICH-1 consists in a large-size hybrid MPGD multilayer layout combining two layers of Thick-GEMs and a bulk resistive MICROMEGAS. Concerning biasing voltage, the Thick-GEMs are segmented in order to reduce the energy released in case of occasional discharges, while the MICROMEGAS anode is segmented in pads individually biased at positive voltage, while the micromesh is grounded. In total, there are ten different electrode types and more than 20000 electrodes supplied by more than 100 HV channels. Commercial power supply units are used. The original elements of the power supply system are the architecture of the voltage distribution net, the compensation, by voltage adjustment, of the effects of pressure and temperature variation affecting the detector gain and a sophisticated control software, which allows to protect the detectors against errors by the operator, to monitor and log voltages and current at 1 Hz rate and to automatically react to detector misbehaviors. The HV system and its performance are described in detail as well as the electrical stability of the detector during the operation at COMPASS.Comment: 5th international conference on Micro-Pattern Gas Detectors (MPGD2017),presentation by Silvia Dalla Torr

Backward pion-nucleon scattering

A global analysis of the world data on differential cross sections and polarization asymmetries of backward pion-nucleon scattering for invariant collision energies above 3 GeV is performed in a Regge model. Including the $N_\alpha$, $N_\gamma$, $\Delta_\delta$ and $\Delta_\beta$ trajectories, we reproduce both angular distributions and polarization data for small values of the Mandelstam variable $u$, in contrast to previous analyses. The model amplitude is used to obtain evidence for baryon resonances with mass below 3 GeV. Our analysis suggests a $G_{39}$ resonance with a mass of 2.83 GeV as member of the $\Delta_{\beta}$ trajectory from the corresponding Chew-Frautschi plot.Comment: 12 pages, 16 figure

Fast Photon Detection for Particle Identification with COMPASS RICH-1

Particle identification at high rates is an important challenge for many current and future high-energy physics experiments. The upgrade of the COMPASS RICH-1 detector requires a new technique for Cherenkov photon detection at count rates of several $10^6$ per channel in the central detector region, and a read-out system allowing for trigger rates of up to 100 kHz. To cope with these requirements, the photon detectors in the central region have been replaced with the detection system described in this paper. In the peripheral regions, the existing multi-wire proportional chambers with CsI photocathode are now read out via a new system employing APV pre-amplifiers and flash ADC chips. The new detection system consists of multi-anode photomultiplier tubes (MAPMT) and fast read-out electronics based on the MAD4 discriminator and the F1-TDC chip. The RICH-1 is in operation in its upgraded version for the 2006 CERN SPS run. We present the photon detection design, constructive aspects and the first Cherenkov light in the detector.Comment: Proceedings of the Imaging 2006 conference, Stockholm, Sweden, 27-30 June 2006, 5 pages, 6 figures, to appear in NIM A; corrected typo in caption of Fig.