1,045 research outputs found
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans
Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions that are causally associated with hypertension. In more recent times, genome-wide studies in humans have also begun to improve our understanding of the inheritance of polygenic forms of hypertension. Based on the chronological progression of research into the genetics of hypertension as the "structural backbone," this review catalogs and discusses the rat and human genetic elements mapped and implicated in blood pressure regulation. Furthermore, the knowledge gained from these genetic studies that provide evidence to suggest that much of the genetic influence on hypertension residing within noncoding elements of our DNA and operating through pervasive epistasis or gene-gene interactions is highlighted. Lastly, perspectives on current thinking that the more complex "triad" of the genome, epigenome, and the microbiome operating to influence the inheritance of hypertension, is documented. Overall, the collective knowledge gained from rats and humans is disappointing in the sense that major hypertension-causing genes as targets for clinical management of essential hypertension may not be a clinical reality. On the other hand, the realization that the polygenic nature of hypertension prevents any single locus from being a relevant clinical target for all humans directs future studies on the genetics of hypertension towards an individualized genomic approach
Nested quantum search and NP-complete problems
A quantum algorithm is known that solves an unstructured search problem in a
number of iterations of order , where is the dimension of the
search space, whereas any classical algorithm necessarily scales as . It
is shown here that an improved quantum search algorithm can be devised that
exploits the structure of a tree search problem by nesting this standard search
algorithm. The number of iterations required to find the solution of an average
instance of a constraint satisfaction problem scales as , with
a constant depending on the nesting depth and the problem
considered. When applying a single nesting level to a problem with constraints
of size 2 such as the graph coloring problem, this constant is
estimated to be around 0.62 for average instances of maximum difficulty. This
corresponds to a square-root speedup over a classical nested search algorithm,
of which our presented algorithm is the quantum counterpart.Comment: 18 pages RevTeX, 3 Postscript figure
The AMANDA Neutrino Telescope and the Indirect Search for Dark Matter
With an effective telescope area of order 10^4 m^2, a threshold of ~50 GeV
and a pointing accuracy of 2.5 degrees, the AMANDA detector represents the
first of a new generation of high energy neutrino telescopes, reaching a scale
envisaged over 25 years ago. We describe its performance, focussing on the
capability to detect halo dark matter particles via their annihilation into
neutrinos.Comment: Latex2.09, 16 pages, uses epsf.sty to place 15 postscript figures.
Talk presented at the 3rd International Symposium on Sources and Detection of
Dark Matter in the Universe (DM98), Santa Monica, California, Feb. 199
The AMANDA Neutrino Telescope: Principle of Operation and First Results
AMANDA is a high-energy neutrino telescope presently under construction at
the geographical South Pole. In the Antarctic summer 1995/96, an array of 80
optical modules (OMs) arranged on 4 strings (AMANDA-B4) was deployed at depths
between 1.5 and 2 km. In this paper we describe the design and performance of
the AMANDA-B4 prototype, based on data collected between February and November
1996. Monte Carlo simulations of the detector response to down-going
atmospheric muon tracks show that the global behavior of the detector is
understood. We describe the data analysis method and present first results on
atmospheric muon reconstruction and separation of neutrino candidates. The
AMANDA array was upgraded with 216 OMs on 6 new strings in 1996/97
(AMANDA-B10), and 122 additional OMs on 3 strings in 1997/98.Comment: 36 pages, 23 figures, submitted to Astroparticle Physic
Nonequilibrium Statistical Mechanics of the Zero-Range Process and Related Models
We review recent progress on the zero-range process, a model of interacting
particles which hop between the sites of a lattice with rates that depend on
the occupancy of the departure site. We discuss several applications which have
stimulated interest in the model such as shaken granular gases and network
dynamics, also we discuss how the model may be used as a coarse-grained
description of driven phase-separating systems. A useful property of the
zero-range process is that the steady state has a factorised form. We show how
this form enables one to analyse in detail condensation transitions, wherein a
finite fraction of particles accumulate at a single site. We review
condensation transitions in homogeneous and heterogeneous systems and also
summarise recent progress in understanding the dynamics of condensation. We
then turn to several generalisations which also, under certain specified
conditions, share the property of a factorised steady state. These include
several species of particles; hop rates which depend on both the departure and
the destination sites; continuous masses; parallel discrete-time updating;
non-conservation of particles and sites.Comment: 54 pages, 9 figures, review articl
Limits on diffuse fluxes of high energy extraterrestrial neutrinos with the AMANDA-B10 detector
Data from the AMANDA-B10 detector taken during the austral winter of 1997
have been searched for a diffuse flux of high energy extraterrestrial
muon-neutrinos, as predicted from, e.g., the sum of all active galaxies in the
universe. This search yielded no excess events above those expected from the
background atmospheric neutrinos, leading to upper limits on the
extraterrestrial neutrino flux. For an assumed E^-2 spectrum, a 90% classical
confidence level upper limit has been placed at a level E^2 Phi(E) = 8.4 x
10^-7 GeV cm^-2 s^-1 sr^-1 (for a predominant neutrino energy range 6-1000 TeV)
which is the most restrictive bound placed by any neutrino detector. When
specific predicted spectral forms are considered, it is found that some are
excluded.Comment: Submitted to Physical Review Letter
Limits to the muon flux from WIMP annihilation in the center of the Earth with the AMANDA detector
A search for nearly vertical up-going muon-neutrinos from neutralino
annihilations in the center of the Earth has been performed with the AMANDA-B10
neutrino detector. The data sample collected in 130.1 days of live-time in
1997, ~10^9 events, has been analyzed for this search. No excess over the
expected atmospheric neutrino background is oberved. An upper limit at 90%
confidence level on the annihilation rate of neutralinos in the center of the
Earth is obtained as a function of the neutralino mass in the range 100
GeV-5000 GeV, as well as the corresponding muon flux limit.Comment: 14 pages, 11 figures. Version accepted for publication in Physical
Review
The AMANDA Neutrino Telescope
With an effective telescope area of order m for TeV neutrinos, a
threshold near 50 GeV and a pointing accuracy of 2.5 degrees per muon
track, the AMANDA detector represents the first of a new generation of high
energy neutrino telescopes, reaching a scale envisaged over 25 years ago. We
describe early results on the calibration of natural deep ice as a particle
detector as well as on AMANDA's performance as a neutrino telescope.Comment: 12 pages, Latex2.09, uses espcrc2.sty and epsf.sty, 13 postscript
files included. Talk presented at the 18th International Conference on
Neutrino Physics and Astrophysics (Neutrino 98), Takayama, Japan, June 199
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