20 research outputs found
Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats
Highly viscous guar gum shifts dietary amino acids from metabolic use to fermentation substrate in domestic cats
Citrulline levels in a paediatric age group : does measurement on dried blood spots have additional value?
Postprandial amino acid sparing conditions of oligofructose and inulin in the strict carnivorous cat
Oligofructose and inulin modulate glucose and amino acid metabolism through propionate production in normal-weight and obese cats
The effect of dietary oligofructose and inulin supplementation on glucose metabolism in obese and non-obese cats was assessed. Two diets were tested in a crossover design; a control diet high in protein (46% on DM basis), moderate in fat (15 %), low in carbohydrates (27 %), but no soluble fibres added; and a prebiotic diet, with 2路5% of a mixture of oligofructose and inulin added to the control diet. Eight non-obese and eight obese cats were allotted to each of two diets in random order at intervals of 4 weeks. At the end of each testing period, intravenous glucose tolerance tests were performed. Area under the glucose curve (AUCgluc) was increased (P=0路022) and the second insulin peak was delayed (P=0路009) in obese compared to non-obese cats. Diets did not affect fasting plasma glucose concentrations, blood glucose response at each glucose time-point after glucose administration, AUCgluc, fasting serum insulin concentrations, area under the insulin curve, and height and appearance time of insulin response. Yet, analysis of acylcarnitines revealed higher propionylcarnitine concentrations (P=0路03) when fed the prebiotic diet, suggesting colonic fermentation and propionate absorption. Prebiotic supplementation reduced methylmalonylcarnitine (P=0路072) and aspartate aminotransferase concentrations (P=0路025), both indicating reduced gluconeogenesis from amino acids. This trial evidenced impaired glucose tolerance and altered insulin response to glucose administration in obese compared to non-obese cats, regardless of dietary intervention; yet modulation of glucose metabolism by enhancing gluconeogenesis from propionate and inhibition of amino acid catabolism can be suggested