A rare case of para-testicular dedifferentiated liposarcoma: a diagnostic dilemma

Paratesticular dedifferentiated liposarcoma (DD-LPS) are rare neoplasms. It has been estimated that 12% of DD-LPS occur in the paratesticular region, while the retroperitoneum is the most common site for this tumor. Herein, we presented a case of a 66-year-old male with a history of pedal edema and right scrotal swelling, CT scan shows a solid mass arising from the right side of the scrotum. Following this, a radical orchiectomy of the right testis with mass was performed, and after thorough microscopic and immunohistochemistry positive for MDM2 and CDK4, the diagnosis of low-grade dedifferentiated liposarcoma was given. This case report expands the morphologic spectrum of dedifferentiated liposarcoma and emphasizes the need to consider these tumours in the differential diagnosis of other neoplasms

Prev Chronic Dis

2013728

Operative indications in recurrent ileocolic intussusception.

BACKGROUND: Air-contrast enema (ACE) is standard treatment for primary ileocolic intussusception. Management of recurrences is less clear. This study aimed to delineate appropriate therapy by quantifying the relationship between recurrence and need for bowel resection, pathologic lead points (PLP), and complication rates. METHODS: After IRB approval, a single institution review of patients with ileocolic intussusception from 1997 to 2013 was performed, noting recurrences, outcomes, and complications. Fisher\u27s exact and t-tests were used. RESULTS: Of 716 intussusceptions, 666 were ileocecal. Forty-four underwent bowel resection, with 29 PLPs and 9 ischemia/perforation. Recurrence after ACE occurred in 96 (14%). Recurrence did not predict PLP (P=0.25). Recurrence (≥3) was associated with higher resection rate (P=0.03), but not ischemia/perforation (P=0.75). ACE-related complications occurred in 4 (0.5%) patients. Successful initial ACE had 98% negative predictive value for resection and PLP (e.g., after successful ACE, 2% had resections, 2% PLP). After failed initial ACE, 36% received resection, and 23% had PLP (P\u3c0.001). CONCLUSIONS: Recurrence is associated with a greater risk of resection but not PLP or ACE-complication. Failed ACE is associated with increased risk for harboring PLP and receiving resection. ACE should be the standard treatment in recurrent intussusception, regardless of number of recurrences