Is there an association between mild cognitive impairment and dietary pattern in chinese elderly? Results from a cross-sectional population study

<p>Abstract</p> <p>Background</p> <p>Diet has an impact on cognitive function in most prior studies but its association with Mild Cognitive Impairment (MCI) in Chinese nonagenarians and centenarians has not been explored.</p> <p>Methods</p> <p>870 elder dujiangyan residents aged 90 years or more in 2005 census were investigated at community halls or at home. They underwent the Mini-Mental State Examination (MMSE) for assessment of cognitive function and replied to our questionnaire comprised of 12 food items and other risk factors. MCI was defined by two steps: first, subjects with post-stroke disease, Alzheimer's disease or Parkinson's disease and MMSE< 18 were excluded; and then subjects were categorized as MCI (MMSE scores between 19 and 24) and normal (MMSE scores between 25 and 30). Logistic regression models were used to analyze the association between diet and the prevalence of MCI. The model was adjusted for gender, ages, systolic blood pressure, diastolic blood pressure, body mass index, fasting plasma glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol, smoking habits, alcohol and tea consumption, educational levels and exercise in baseline dietary assessment.</p> <p>Results</p> <p>364 elderly finally included, 108 (38.71%) men and 171 (61.29%) women of whom were classified as MCI. A significant correlation between MCI and normal in legume was observed (OR, 0.84; 95%CI, 0.72-0.97), and also in animal oil (any oil that obtained from animal substances) (OR, 0.93; 95%CI, 0.88-0.98). There was no statistical difference of other food items between normal and MCI.</p> <p>Conclusions</p> <p>Among Chinese nonagenarians and centenarians, we found there were significant associations between inadequate intake of legume and animal oil and the prevalence of MCI. No significant correlation between other food items and the prevalence of MCI were demonstrated in this study.</p

Intelligence in Tourism Management: A Hybrid FOA-BP Method on Daily Tourism Demand Forecasting with Web Search Data

The Chinese tourism industry has been developing rapidly for the past several years, and the number of people traveling has been increasing year by year. However, many problems still beset current tourism management. Lack of effective management has caused numerous problems, such as tourists stranded during tourist season and the declining service quality of scenic spots, which have become the focus of tourists&rsquo; attention. Network search data can intuitively reflect the attention of most users through the combination of the network search index and the back propagation (BP) neural network model. This study predicts the daily tourism demand in the Huangshan scenic spot in China. The filtered keyword in the Baidu index is added to the hybrid neural network, and a BP neural network model optimized by a fruit fly optimization algorithm (FOA) based on the web search data is established in this study. Different forecasting methods are compared in this paper; the results prove that compared with other prediction models, higher accuracy can be obtained when it comes to the peak season using the FOA-BP method that includes web search data, which is a sustainable means of practically solving the tourism management problem by a more accurate prediction of tourism demand of scenic spots

Jet formation and penetration performance of a double-layer charge liner with chemically-deposited tungsten as the inner liner

This paper proposes a type of double-layer charge liner fabricated using chemical vapor deposition (CVD) that has tungsten as its inner liner. The feasibility of this design was evaluated through penetration tests. Double-layer charge liners were fabricated by using CVD to deposit tungsten layers on the inner surfaces of pure T2 copper liners. The microstructures of the tungsten layers were analyzed using a scanning electron microscope (SEM). The feasibility analysis was carried out by pulsed X-rays, slug-retrieval test and static penetration tests. The shaped charge jet forming and penetration law of inner tungsten-coated double-layer liner were studied by numerical simulation method. The results showed that the double-layer liners could form well-shaped jets. The errors between the X-ray test results and the numerical results were within 11.07%. A slug-retrieval test was found that the retrieved slug was similar to a numerically simulated slug. Compared with the traditional pure copper shaped charge jet, the penetration depth of the double-layer shaped charge liner increased by 11.4% and >10.8% respectively. In summary, the test results are good, and the numerical simulation is in good agreement with the test, which verified the feasibility of using the CVD method to fabricate double-layer charge liners with a high-density and high-strength refractory metal as the inner liner

Analysis of the relationship between three coding polymorphisms in LEPR gene and obesity in northern Chinese

To determine the effect of variants in LEPR gene on obesity in northern Chinese, three coding polymorphisms Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were investigated for association with overweight and obesity. By a case control design, 248 overweight or obese subjects and 351 lean normal controls were recruited in Harbin region in north China. All three polymorphisms were genotyped by Sequenom single nucleotide polymorphism (SNP) detection system in both cases and controls. Genotypes for all three polymorphisms were in Hardy–Weinberg equilibrium in control subjects. Both groups had similar distribution of alleles and genotypes created by the three coding polymorphisms of LEPR gene. No differences in frequencies of genotypes or alleles between cases and controls for any polymorphism individually were found by χ2 analysis (p = 0.444, p = 0.507 and p = 0.662, respectively). Further, when the haplotypes of three polymorphisms were assessed, no association for any haplotype of three polymorphisms was revealed. In the present study, the three coding polymorphisms in LEPR gene were firstly investigated in a population of northern Chinese. It was suggested that the three coding polymorphisms in LEPR gene were unlikely to have major effects on susceptibility to obesity in northern Chinese.To determine the effect of variants in LEPR gene on obesity in northern Chinese, three coding polymorphisms Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were investigated for association with overweight and obesity. By a case control design, 248 overweight or obese subjects and 351 lean normal controls were recruited in Harbin region in north China. All three polymorphisms were genotyped by Sequenom single nucleotide polymorphism (SNP) detection system in both cases and controls. Genotypes for all three polymorphisms were in Hardy-Weinberg equilibrium in control subjects. Both groups had similar distribution of alleles and genotypes created by the three coding polymorphisms of LEPR gene. No differences in frequencies of genotypes or alleles between cases and controls for any polymorphism individually were found by chi(2) analysis (p=0.444, p=0.507 and p=0.662, respectively). Further, when the haplotypes of three polymorphisms were assessed, no association for any haplotype of three polymorphisms was revealed. In the present study, the three coding polymorphisms in LEPR gene were firstly investigated in a population of northern Chinese. It was suggested that the three coding polymorphisms in LEPR gene were unlikely to have major effects on susceptibility to obesity in northern Chinese. (c) 2007 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved

The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese

http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000258990100011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Genetics &amp; HereditySCI(E)1ARTICLE2165-U58

Preliminary development of a conceptual first wall for DEMO

The first wall is one of the key components in a tokamak, in particular, for DEMO in the future. The conceptual first wall for a DEMO reactor is designed, fabricated and tested in this paper. It has a sandwich-like structure, which consists of a reduced activation ferritic/martensitic (RAFM) substrate, an interlayer and a plasma-facing material of tungsten produced by chemical vapor deposition (CVD-W) due to its characteristics of high density, high purity and superior thermal shock resistance. The interlayer is required to not only have good adhesion between CVD-W and the CLF-1 substrate, which is a type of RAFM developed by the Southwestern Institute of Physics, but also the capability of tritium transport prevention due to the great importance of controlling the tritium buildup in the first wall, improving the fuel efficiency and conforming to the safety regulations of tritium. Titanium nitride (TiN), a well-known tritium barrier, is selected as the interlayer material in this work. In total, eight sandwich-like first wall samples have been fabricated, and thermal cycle tests and plasma exposure tests are implemented. The results of material analysis show that the quality of the TiN coating layer is critical for good adhesion and tritium prevention. At the defects of the TiN interlayer, fluorine (F) penetrated into the CLF-1 during the CVD-W fabrication and, as a result, the sandwich-like structure was broken near the CLF-1 side. For some samples, the TiN interlayer made by CVD has sufficient adhesion as an interlayer between CVD-W and CLF-1 during tests so far. These encouraging test results support further examination of TiN as an interlayer material for W on an RAFM steel as a first wall material. Preliminary results indicate that the design and fabrication of the conceptual first wall are feasible. Further tests, including the improvement of the interlayer quality and the tritium permeation test, are necessary in the future

Table_1_SVep1, a temperate phage of human oral commensal Streptococcus vestibularis.docx

IntroductionBacteriophages play a vital role in the human oral microbiome, yet their precise impact on bacterial physiology and microbial communities remains relatively understudied due to the limited isolation and characterization of oral phages. To address this gap, the current study aimed to isolate and characterize novel oral phages.MethodsTo achieve this, oral bacteria were isolated using a culture-omics method from 30 samples collected from healthy individuals. These bacteria were then cultured in three different types of media under both aerobic and anaerobic conditions. The samples were subsequently subjected to full-length 16S rRNA gene sequencing for analysis. Subsequently, we performed the isolation of lytic and lysogenic phages targeting all these bacteria.ResultsIn the initial step, a total of 75 bacterial strains were successfully isolated, representing 30 species and 9 genera. Among these strains, Streptococcus was found to have the highest number of species. Using a full-length 16S rRNA gene similarity threshold of 98.65%, 14 potential novel bacterial species were identified. In the subsequent phase, a temperate phage, which specifically targets the human oral commensal bacterium S. vestibularis strain SVE8, was isolated. The genome of S. vestibularis SVE8 consists of a 1.96-megabase chromosome, along with a 43,492-base pair prophage designated as SVep1. Annotation of SVep1 revealed the presence of 62 open reading frames (ORFs), with the majority of them associated with phage functions. However, it is worth noting that no plaque formation was observed in S. vestibularis SVE8 following lytic induction using mitomycin C. Phage particles were successfully isolated from the supernatant of mitomycin C-treated cultures of S. vestibularis SVE8, and examination using transmission electron microscopy confirmed that SVep1 is a siphovirus. Notably, phylogenetic analysis suggested a common ancestral origin between phage SVep1 and the cos-type phages found in S. thermophilus.DiscussionThe presence of SVep1 may confer immunity to S. vestibularis against infection by related phages and holds potential for being engineered as a genetic tool to regulate oral microbiome homeostasis and oral diseases.</p