An Investigation on the antimicrobial activity of some endemic plant species from Turkey

WOS: 000254899200001In this study performed on six endemic plant species, antimicrobial activity was observed in Campanula lyrata subsp. lyrata and Abies nordmanniana subsp. bornmuelleriana plants. The minimum inhibitory concentration of C. lyrata subsp. lyrata (leaf and flower) extract was found to be >= 29 mg/ml for Baccillus subtilis and >= 14.5 mg/ml for Staphylococcus aureus, and the minimum inhibitory concentration (MIC) of Abies nordmanniana subsp. bornmuelleriana (leaf) extract was found to be > 314 mg/ml for B. subtilis and when minimum bacteriocidal concentration (MBC) results were evaluated, it was observed that the plant extracts had bacteriocidal effects. No antimicrobial activity was observed in the other plant extracts, namely, Onosma bornmuelleri (leaf-flower), Dianthus balansae (leaf-flower), Alyssum pateri subsp. pateri (seed) and Scabiosa columbaria subsp. paphlagonica (leaf) extracts that were tested

Antimicrobial activity of endemic Digitalis lamarckii Ivan from Turkey

WOS: 000264047500011PubMed: 19405389Antimicrobial activity of the methanolic extracts of leaves and flowers of D. lamarckii Ivan, (Scophulariaceae), an endemic plant species of Turkey, was tested on ten bacterial and four yeast strains. Effective antibacterial activity was observed in four bacterial strains. Minimum inhibitory concentration (MIC) was calculated by use of liquid culture tests and in all the four effective bacterial strains, the MIC was found to be >= 199.5 mg/ml. The minimum bactericidal concentration (MBC) of B. subtilis, S. aureus, and L. monocytogenes was calculated to be >= 199.5 mg/ml, and MBC value for Shigella was calculated as >= 399 mg/ml.Technical and Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK, TBAG-HD/107(105T542)]This study was financially supported by a grand from the Technical and Research Council of Turkey (TUBITAK, TBAG-HD/107(105T542))

Antimicrobial activity of some endemic plant species from Turkey

WOS: 000248685500008Six plant extracts obtained from different parts such as the leaves, flowers and seeds of four species of the endemic plants in Turkey were tested on a total of 14 microorganisms, 10 of which were bacterial strains and 4 yeast strains. Verbascum eriocarpum (flower) extract was found to be effective against Staphylococcus aureus; Stachys cretica subsp. anatolica (leaf and flower) and Heracleum paphlagonicum (seed) extracts were found to be effective against Bacillus subtilis; and Alcea apterocarpa (seed and sepal) extract was found to be effective against Pseudomonas aeruginosa. No antimicrobial activity was observed in Heracleum paphlagonicum (leaf) and Alcea apterocarpa (leaf) plant extracts. The minimum inhibitory concentration (MIC) values of the plant extracts were calculated to be between >= 0.859 mg/ml and >= 110.5 mg/ml and the minimum bacteriocidal concentration (MBC) values were calculated to be between >= 3.44 mg/ml and >= 132 mg/ml

One-step injectable and bioreducible poly(β-amino ester) hydrogels as controlled drug delivery platforms

A one-step synthesis strategy based on aza-Michael reaction of poly(ethylene glycol) diacrylate (PEGDA) or PEGDA/1,6-hexanediol diacrylate (HDDA) mixture and cystamine was employed to fabricate injectable, biocompatible and degradable novel poly(β-amino ester) (PBAE) hydrogels. The gelation was monitored by real-time dynamic rheological measurements in order to follow formation of the PBAE hydrogel networks. The obtained hydrogels were responsive to both pH and redox state which enabled the control of swelling, degradation and release properties by external triggers. Degradation products of the hydrogels were shown to have no significant cytotoxicity on A549 adenocarcinomic human alveolar basal epithelial cells and MCF-7 human breast cancer cells. The hydrogels were loaded with a photosensitizer, methylene blue (MB), as a model compound by simply adding the MB molecules into the precursor mixture. The activity of released MB was assessed by in vitro photodynamic therapy (PDT) studies conducted with A549 cells

The Effects of Local and Systemic Growth Hormone Treatment on Germ Cell Population and Fertility in an Experimental Unilateral Testicular Torsion and Orchiectomy Model

Purpose: We evaluated the effects of local and systemic growth hormone on the germ cell population of the contralateral testes of pubertal rats subjected to unilateral testicular torsion and orchiectomy 24 hours later

Effects of Local and Sustained Release of FGF, IGF, and GH on Germ Cells in Unilateral Undescended Testis in Rats

OBJECTIVES To evaluate the effects of the local release of fibroblast growth factor (FGF), insulin-like growth factor (IGF), and growth hormone (GH) on a germ cell population of ipsilateral undescended and contralateral descended testes of rats with a surgically created unilateral abdominal testis for 12 weeks and after the application of growth factors after orchidopexy