The Teaching of Highlighting Mathematical Culture from the Perspective of HPM ——Take the Teaching for "Letters Represent Numbers" as an Example

"Compulsory Education Mathematics Curriculum Standards (2022 Edition)" clearly states that attention should be paid to mathematics culture, but at present, mathematics textbooks and classrooms still do not attach importance to mathematics culture, and mathematics culture is not really integrated into mathematics classroom teaching. For further exploring how to integrate mathematical culture into mathematical classroom teaching, the traditional teaching design of Letters Represent Numbers is transformed from the perspective of HPM by taking Letters Represent Numbers as a case, and the history of mathematics is used to highlight the mathematical culture embedded in mathematical knowledge, and based on this, ideas and suggestions are put forward for teaching to highlight mathematical culture from the perspective of HPM. Keywords: HPM; Mathematical Culture; Letters Represent Numbers; Teaching Design DOI: 10.7176/JEP/13-35-07 Publication date: December 31st 2022

Exploration of Ideology and Politics Education in Analytical Geometry Under Blending Teaching

With the rapid development and continuous innovation of information technology, traditional teaching model is confronted with great challenge and, sometimes, it is difficult to achieve teaching goals via single offline teaching, especially under the influence of the COVID-19. In this paper, taking space rectangular coordinates and space vector in the course of space analytical geometry as the carrier, ideological and political elements in the course of space analytical geometry is mined via multi-channel from various aspects. Fusion point of ideology and politics elements in space analytical geometry is searched and the implementation path is investigated under blending teaching. The aim is to promote the achievement of the ideology and politics education of space analytical geometry. Keywords: Blending teaching, Ideology and politics education, Analytical geometry DOI: 10.7176/JEP/13-21-15 Publication date:June 30th 202

An Analysis of the Implementation Path of Moral Education in Mathematics under Goal Orientation: Taking "The ellipse and its standard equation" as an example

The practice of moral education in mathematics is an inevitable requirement for the implementation of the fundamental task of establishing moral education. The practice of moral education in mathematics is not conducted blindly. By adopting moral education objectives as the guide, the effectiveness of moral education in the subject can be enhanced. The implementation path of moral education in mathematics was explored in the context of the moral education objectives for the senior secondary level in the "Guidelines for Moral Education in Primary and Secondary Schools", based on the example of the "ellipse and its standard equation". A typical case was used as a carrier; reasonable scenarios were introduced; mathematical thinking and methods were penetrated to focus on the cultural values of mathematics. Keywords: Moral education in mathematics; Goal-oriented; Ellipse DOI: 10.7176/JEP/13-26-06 Publication date:September 30th 202

Differentially Regulated Apolipoproteins and Lipid Profiles as Novel Biomarkers for Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration

Lipid dyshomeostasis has been implicated in the pathogenesis of various retinal and choroidal vascular diseases. This study aims to investigate whether apolipoprotein (apo) mediated differential regulation of lipid metabolism contributes to the phenotypes of polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD). This study involved 148 subjects including 53 patients with PCV, 44 patients with nAMD, and 51 age-, sex-matched subjects with normal fundus controls. Routine blood biochemistry profile was evaluated. Apolipoproteins was estimated by Luminex technology. After controlling for age, gender, body mass index, duration of hypertension and type 2 diabetes mellitus, apoB/non-high density lipoprotein cholesterol (HDL-C) (p=0.015) was an independent risk factor for nAMD, apoB was an independent risk factor for PCV(p=0.011), compared with control. Low-density lipoprotein cholesterol (LDL-C) was significantly higher in patients with PCV when compared with nAMD (p=0.037). Furthermore, apoB/non-HDL, LDL-C, triglycerides and were significantly correlated with the pathogenesis of subgroups of PCV and nAMD. We concluded that lipid profiles and apos are differential regulated in PCV, nAMD and their subtypes, indicating different pathogenicity contributed to the different phenotypes of PCV and nAMD. Non-pachy PCV shares pathological similarities with nAMD, which is highly correlated with age-related atherosclerosis

Characterization of Choroidal Morphology and Vasculature in the Phenotype of Pachychoroid Diseases by Swept-Source OCT and OCTA

The objective of this study was to characterize the choroidal morphology and vasculature in pachychoroid diseases (PCD). A total of 49 eyes with polypoidal choroidal vasculopathy (PCV), 43 eyes with neovascular age-related macular degeneration (nAMD), and 50 eyes with central serous chorioretinopathy (CSC), along with 80 healthy eyes, were enrolled in this nested case-control study. The swept-source optical coherent tomography (OCT), OCT angiography, and En face images were quantitatively analyzed. Multivariate logistic regression models showed that older age and increased vessel density (VD) in the choriocapillaris (CC) layer were independent risk factors for both PCV (page < 0.001, pVD = 0.004), and nAMD (page < 0.001, pVD = 0.005). Decreased VD in the Sattler’s layer was an independent risk factor for PCV (p = 0.014). Increased VD in the Haller’s layer was an independent risk factor for CSC (p = 0.001). The proportion of the diffuse type of collateral circulation in the Sattler’ layer in CSC group was significantly higher than in the other three groups (p < 0.001). We concluded that the involvement of the blood flow in the CC, Haller’s, and Sattler’s layers are differently affected in CSC, nAMD, and PCV eyes, indicating the different pathological mechanism underlying the phenotype of PCD. The age-dependent establishment of collateral circulation in the Sattler’s layer may play a compensatory role regarding ischemic injury in the development of PCD

Unveiling Antibacterial and Antibiofilm Mechanisms of Methyleugenol: Implications for Ecomaterial Functionalization

Bacterial resistance evolution necessitates the continuous adaptation of antimicrobial agents. In this study, we systematically investigated the antibacterial and biofilm-inhibition mechanisms of plant extracts, including methyleugenol and eugenol, and further explored their potential for immobilization in practical applications. Our findings revealed that eugenol exhibited robust antibacterial activity by disrupting bacterial redox balance and membrane permeability. Methyleugenol, on the other hand, efficiently mitigated biofilm formation by inhibiting the quorum sensing (QS) system and depolarizing the cell membrane. Through gene expression analysis and molecular docking studies, we confirmed that methyleugenol suppressed the transcriptional expression of QS regulatory genes by competitively binding to the RhlR receptor protein, thereby reducing the secretion of extracellular polymeric substances and inhibiting the biofilm formation. Furthermore, we observed an upregulation of multiple efflux pump MexAB-OprM as a response to bacterial reductive stress during compound exposure. To expand the practical utility of these findings, we successfully grafted methyleugenol onto glass surfaces using the atom transfer radical polymerization method, demonstrating enduring antibacterial and antibiofilm properties. Overall, our study offers a comprehensive understanding of the antibacterial and antibiofilm mechanisms of methyleugenol and eugenol, with promising applications for enhancing ecomaterial functionalization

Circulating tumor cells in pulmonary vein and peripheral arterial provide a metric for PD-L1 diagnosis and prognosis of patients with non-small cell lung cancer.

BackgroundLung cancer is the leading cause of death caused by malignant tumors. PD-L1(programmed cell death protein-1) has shown tremendous achievement in treating NSCLC. We sought to find the relationship between CTCs in the pulmonary vein and postoperative PFS, besides we detected PD-L1 in CTCs.MethodWe enrolled 112 NSCLC patients. CTC tests were performed at four time points (preoperative, pulmonary vein, intraoperative and postoperative) on every NSCLC patient who received surgery. The RNA of PD-L1 was tested by FISH. The levels of the PD-L1 mRNA and protein in tissue samples were detected.ResultsThe CTCs in the PV were the highest (P 0.05) or LN metastasis (P> 0.05). In total, fifty-two (50.5%) patients had positive PD-L1 expression in CTC. In PD-L1-positive CTC patients, the value of PD-L1 tissue expression was higher than that in PD-L1-negative CTC patients (P = 0.0153).ConclusionCTCs in the pulmonary vein can be an effective prognosis indicator of NSCLC patients

Alisol B 23-Acetate Inhibits IgE/Ag-Mediated Mast Cell Activation and Allergic Reaction

Alisol B 23-acetate (AB23A), a natural triterpenoid, has been reported to exert hepatoprotective and antitumor activities. Aiming to investigate the anti-inflammatory activity, this study examined the effect of AB23A on mast cells and allergic reaction. AB23A inhibited the degranulation of mast cells stimulated by immunoglobulin E/antigen (IgE/Ag), and also decreased the synthesis of leukotriene C4 (LTC4), production of interlukin-6 (IL-6), and expression of cyclooxygenase-2 (COX-2) in a concentration-dependent manner with no significant cytotoxicity in bone marrow-derived mast cells (BMMCs). AB23A inhibited spleen tyrosine kinase (Syk) and the downstream signaling molecules including phospholipase Cγ (PLCγ), serine-threonine protein kinase/inhibitor of nuclear factor kappa-B kinase/nuclear factor kappa-B (Akt/IKK/NF-κB), and mitogen-activated protein kinases/cytosolic phospholipase A2 (MAPK/cPLA2). Furthermore, AB23A blocked mobilization of Ca2+. Similar results were obtained in other mast cell lines Rat basophilic leukemia (RBL)-2H3 cells and a human mast cell line (HMC-1). In addition, AB23A attenuated allergic responses in an acute allergy animal model, passive cutaneous anaphylaxis (PCA). Taken together, this study suggests that AB23A inhibits the activation of mast cells and ameliorates allergic reaction, and may become a lead compound for the treatment of mast cell-mediated allergic diseases