The impact of disturbed galaxy clusters on the kinematics of active galactic nuclei

© 2020 The Author(s) We produce a kinematic analysis of AGN-hosting cluster galaxies from a sample of 33 galaxy clusters selected using the X-ray Clusters Database (BAX) and populated with galaxies from the Sloan Digital Sky Survey Data Release 8. The 33 galaxy clusters are delimited by their relative intensity of member galaxy substructuring as a proxy to core merging to derive two smaller sub-samples of 8 dynamically active (merging) and 25 dynamically relaxed (non-merging) states. The AGN were selected for each cluster sub-sample by employing the WHAN diagram to the strict criteria of log10([N II]/Hα) ≥ −0.32 and EWHα ≥ 6 Å, providing pools of 70 mergings and 225 non-merging AGN sub-populations. By co-adding the clusters to their respective dynamical states to improve the signal-to-noise ratio of our AGN sub-populations we find that merging galaxy clusters on average host kinematically active AGN between 0-1.5r200 as r200 → 0, where their velocity dispersion profile (VDP) presents a significant deviation from the non-AGN sub-population VDP by ≳3σ. This result is indicative that the AGN-hosting cluster galaxies have recently coalesced on to a common potential. Further analysis of the composite distributions illustrates non-merging AGN-hosting sub-populations have, on average, already been accreted and predominantly lie within backsplash regions of the projected phase-space. This suggests merging cluster dynamical states hold relatively younger AGN sub-populations kinematically compared with those found in non-merging cluster dynamical states

The rotational profiles of cluster galaxies

© 2019 The Author(s) We compile two samples of cluster galaxies with complimentary hydrodynamic and N-body analysis using FLASH code to ascertain how their differing populations drive their rotational profiles and to better understand their dynamical histories.We select our main cluster sample from the X-ray Galaxy Clusters Database (BAX), which are populated with Sloan Digital Sky Survey (SDSS) galaxies. The BAX clusters are tested for the presence of substructures, acting as proxies for core mergers, culminating in sub-samples of eight merging and 25 non-merging galaxy clusters. An additional sample of 12 galaxy clusters with known dumbbell components is procured using galaxy data from the NASA/IPAC Extragalactic Database (NED) to compare against more extreme environments. BAX clusters of each sample are stacked on to a common RA-Dec. space to produce rotational profiles within the range of 0.0-2.5 r200. Merging stacks possess stronger core rotation at ≲0.5r200 primarily contributed by a red galaxy sub-population from relaxing core mergers; this is alongside high rotational velocities from blue galaxy sub-populations, until they mix and homogenize with the red sub-populations at ∼r200, indicative of an infalling blue galaxy sub-population with interactive mixing between both sub-populations at ≿ r200. FLASH code is utilized to simulate the merger phase between two originally independent clusters and test the evolution of their rotational profiles. Comparisons with the dumbbell clusters leads to the inference that the peculiar core rotations of some dumbbell clusters are the result of the linear motions of core galaxies relaxing on to the potential during post second infall

The kinematics of cluster galaxies via velocity dispersion profiles

© 2018 The Author(s). We present an analysis of the kinematics of a sample of 14 galaxy clusters via velocity dispersion profiles (VDPs), compiled using cluster parameters defined within the X-Ray Galaxy Clusters Database (BAX) cross-matched with data from the Sloan Digital Sky Survey (SDSS). We determine the presence of substructure in the clusters from the sample as a proxy for recent core mergers, resulting in 4 merging and 10 non-merging clusters to allow for comparison between their respective dynamical states. We create VDPs for our samples and divide them by mass, colour, and morphology to assess how their kinematics respond to the environment. To improve the signal-to-noise ratio our galaxy clusters are normalized and co-added to a projected cluster radius at 0.0-2.5r200. We find merging cluster environments possess an abundance of a kinematically active (rising VDP) mix of red and blue elliptical galaxies, which is indicative of infalling substructures responsible for pre-processing galaxies. Comparatively, in non-merging cluster environments galaxies generally decline in kinematic activity as a function of increasing radius, with bluer galaxies possessing the highest velocities, likely as a result of fast infalling field galaxies. However, the variance in kinematic activity between blue and red cluster galaxies across merging and non-merging cluster environments suggests galaxies exhibit differing modes of galaxy accretion on to a cluster potential as a function of the presence of a core merger

Project ThaiPASS: international outreach blending astronomy and Python

We present our outreach program, the Thailand-UK Python+Astronomy Summer School (ThaiPASS), a collaborative project comprising UK and Thai institutions and assess its impact and possible application to schools in the United Kingdom. Since its inception in 2018, the annual ThaiPASS has trained around 60 Thai high-school students in basic data handling skills using Python in the context of various astronomy topics, using current research from the teaching team. Our impact assessment of the 5 day summer schools shows an overwhelmingly positive response from students in both years, with over 80% of students scoring the activities above average in all activities but one. We use this data to suggest possible future improvements. We also discuss how ThaiPASS may inspire further outreach and engagement activities within the UK and beyond

Project ThaiPASS: international outreach blending astronomy and Python

We present our outreach program, the Thailand–UK Python+Astronomy Summer School (ThaiPASS), a collaborative project comprising UK and Thai institutions and assess its impact and possible application to schools in the United Kingdom. Since its inception in 2018, the annual ThaiPASS has trained around 60 Thai high-school students in basic data handling skills using Python in the context of various astronomy topics, using current research from the teaching team. Our impact assessment of the 5 day summer schools shows an overwhelmingly positive response from students in both years, with over 80% of students scoring the activities above average in all activities but one. We use this data to suggest possible future improvements. We also discuss how ThaiPASS may inspire further outreach and engagement activities within the UK and beyond

Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

Purpose: Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods: Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results: The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion: We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes

Therapy-induced APOBEC3A drives evolution of persistent cancer cells

Acquired drug resistance to anticancer targeted therapies remains an unsolved clinical problem. Although many drivers of acquired drug resistance have been identified1-4, the underlying molecular mechanisms shaping tumour evolution during treatment are incompletely understood. Genomic profiling of patient tumours has implicated apolipoprotein B messenger RNA editing catalytic polypeptide-like (APOBEC) cytidine deaminases in tumour evolution; however, their role during therapy and the development of acquired drug resistance is undefined. Here we report that lung cancer targeted therapies commonly used in the clinic can induce cytidine deaminase APOBEC3A (A3A), leading to sustained mutagenesis in drug-tolerant cancer cells persisting during therapy. Therapy-induced A3A promotes the formation of double-strand DNA breaks, increasing genomic instability in drug-tolerant persisters. Deletion of A3A reduces APOBEC mutations and structural variations in persister cells and delays the development of drug resistance. APOBEC mutational signatures are enriched in tumours from patients with lung cancer who progressed after extended responses to targeted therapies. This study shows that induction of A3A in response to targeted therapies drives evolution of drug-tolerant persister cells, suggesting that suppression of A3A expression or activity may represent a potential therapeutic strategy in the prevention or delay of acquired resistance to lung cancer targeted therapy

‘It's good for their self-esteem’: the substance beneath the label

This paper provides an informed and critical understanding of the concept of self-esteem. It explores this psychological construct in relation to its use in adventure education and outdoor learning. Enhancing a participant’s self-esteem is perceived to be fundamentally a good thing and is culturally linked to the Hahnian notion that implies outdoor education is good for character-building and more recently personal development. This paper suggests that the improvement of self-esteem has become a reified programme outcome as well as an argument for the value and importance of outdoor education programmes. In this paper I seek to address the often uncritical and at times evangelical claim that outdoor programmes enhance self-esteem. This paper looks at the development of self-esteem generally and then considers its appearance in the outdoor education literature. Aspects of this that relate to outdoor learning and adventure education include: development of the self, behaviour, disaffected young people, recent UK developments and common misconceptions regarding self-esteem. These are explored and their implications for practice and research are considered. The essence of this paper is that outdoor educators need to be more critical, informed and specific about exactly what it is they are trying to achieve, how their programmes are evaluated, particularly with outcomes that are related to potential changes in ‘self’ and how these changes are measured