Juvenile idiopathic scoliosis treated with posterior arthrodesis and segmental pedicle screw instrumentation before the age of 9 years: a 5-year follow-up

<p>Abstract</p> <p>Study design</p> <p>Retrospective study.</p> <p>Objective</p> <p>To evaluate the radiological results of fusion with segmental pedicle screw fixation in juvenile idiopathic scoliosis with a minimum 5-year follow-up.</p> <p>Summary of background data</p> <p>Progression of spinal deformity after posterior instrumentation and fusion in immature patients has been reported by several authors. Segmental pedicle screw fixation has been shown to be effective in controlling both coronal and sagittal plane deformities. However, there is no long term study of fusion with segmental pedicle screw fixation in these group of patients.</p> <p>Methods</p> <p>Seven patients with juvenile idiopathic scoliosis treated by segmental pedicle screw fixation and fusion were analyzed. The average age of the patients was 7.4 years (range 5–9 years) at the time of the operation. All the patients were followed up 5 years or more (range 5–8 years) and were all Risser V at the most recent follow up. Three dimensional reconstruction of the radiographs was obtained and 3DStudio Max software was used for combining, evaluating and modifying the technical data derived from both 2d and 3d scan data.</p> <p>Results</p> <p>The preoperative thoracic curve of 56 ± 15° was corrected to 24 ± 17° (57% correction) at the latest follow-up. The lumbar curve of 43 ± 14° was corrected to 23 ± 6° (46% correction) at the latest follow-up. The preoperative thoracic kyphosis of 37 ± 13° and the lumbar lordosis of 33 ± 13° were changed to 27 ± 13° and 42 ± 21°, respectively at the latest follow-up. None of the patients showed coronal decompensation at the latest follow-up. Four patients had no evidence of crankshaft phenomenon. In two patients slight increase in Cobb angle at the instrumented segments with a significant increase in AVR suggesting crankshaft phenomenon was seen. One patient had a curve increase in both instrumented and non instrumented segments due to incorrect strategy.</p> <p>Conclusion</p> <p>In juvenile idiopathic curves of Risser 0 patients with open triradiate cartilages, routine combined anterior fusion to prevent crankshaft may not be warranted by posterior segmental pedicle screw instrumentation.</p

Osteoid osteoma of the iliac bone associated with bilateral sacroiliitis: a case report

WOS: 000282599500012Osteoid osteoma is one of the infrequent causes of musculoskeletal pain. Rheumatic diseases such as ankylosing spondylitis are considered especially in cases of bilateral sacroiliitis. An association between these diseases is uncommon. Since both osteoid osteoma and sacroliitis response well to antiinflammatory therapy, radiological investigations, such as computed tomography (CT), have a significant role in diagnosis due to its superiority in visualizing the osseous tissue. Thus, this rare condition can not only be diagnosed, but also managed. This report presents a case of bilateral sacroiliitis in association with osteoid osteoma in a 23-year-old male patient, who was diagnosed and treated initially as bilateral sacroiliitis. CT was performed in order to evaluate the sacroiliac joint space and the accompanying osteoid osteoma was detected coincidentally. Turk J Phys Med Rehab 2010;56:152-4

Isolated avulsion fracture of lesser tuberosity of the humerus: Review of the literature and report of two cases

Two cases of acute isolated avulsion fracture of the lesser tuberosity of the humerus and their short-term outcome are presented with a review of previously reported cases. Open reduction and internal fixation was performed. Outcomes were excellent, and the patients regained their normal pain-free shoulder function 3 months after the operation. This was a Level IV study

Resveratrol improves hepatic insulin signaling and reduces the inflammatory response in streptozotocin-induced diabetes

WOS:000360511100008PubMed:26071184Diabetes mellitus is a heterogeneous metabolic disorder essentially characterized by deficiency of insulin secretion, insulin receptor or post-receptor events. This study aims to investigate the effects of resveratrol administration on the metabolic characteristics, hepatic functions, histopathological features and insulin signaling pathway components in streptozotocin induced diabetes. Male Wistar rats were randomly divided into four groups: (1) control/vehicle; (2) control/20 mg/kg resveratrol; (3) diabetic/vehicle; and (4) diabetic/20 mg/kg resveratrol. Histopathological examinations were carried out to reveal hepatic tissue damage and inflammation. In addition to hepatic glucose, lipid, insulin, ALT, AST, resistin and XOD contents, gene and protein expressions of insulin signaling pathway components such as insulin RI3, IRS-1, IRS-2, eNOS, PI3K, Alct, and FOX03a were analyzed by qRT-PCR and Western blot. The rats in the diabetes group had significantly lower terminal body weight and hepatic insulin level, but significantly higher hepatic glucose, total cholesterol, triglyceride and resistin concentrations. Diabetes triggered the inflammatory process in the liver tissues that was evidenced by histopathological deformations and increase in the hepatic ALT and AST levels. Hepatic inflammation was considerably associated with insulin signaling pathway ever since a significant down-regulation of insulin signaling components; IRS-1, IRS-2, PI3K, Alct and mTOR have been identified in the diabetic group. To some extent, resveratrol treatment reversed the diabetes-induced changes in the liver tissues. Taken together, resveratrol partly improved hepatic dysfunction induced by diabetes. This may be due to the healing activity of resveratrol on insulin signaling pathway, resistin levels and hepatic glucose-lipid contents. 0 2015 Elsevier B.V. All rights reserved.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [3501/112T159]This study was supported by grants from TUBITAK Research Fund (3501/112T159)

Potential cytotoxic effects of borax alone and in combination with irinotecan on YKG1 glioblastoma cell-line

Glioblastoma Multiforme (GBM), which is a common and primary brain tumor in adults, is an important cause of death worldwide as an aggressive and treatment-resistant cancer tumor. In this cell culture study, the apoptotic and anti-proliferative effects of borax and irinotecan at different doses, alone or in combination, were investigated in the YKG1 cell line. Cytotoxic activities were analyzed by MTT method and TUNEL staining after 24th and 48th hours of incubation with borax administered at doses of 1mg and 3mg per ml; irinotecan 50mM and 100mM. Both irinotecan and borax have been shown to induce apoptosis when used alone, and thus cause anti-proliferation. It was determined that these effects were potentiated by the combined application of the agents. In addition, it was determined that this effect in combined applications was more pronounced after 48 hours and at higher doses. In light of the data obtained, the combination of irinotecan with borax to increase the cytotoxic effect of irinotecan, which is used in many different cancer types, can be tried in further prospective studies. [Med-Science 2023; 12(1.000): 26-31

Spontaneous osteonecrosis of the tarsal navicular in an adult: Mueller-weiss syndrome

WOS: 000287730300018PubMed: 21354008Spontaneous osteonecrosis of the navicular in the adult is known as Mueller-Weiss syndrome, which is a rare disease characterized by a collapse of the lateral portion of the tarsal navicular combined with a medial protrusion of the talar head and peri-navicular osteoarthritis. In this article, we describe a case of spontaneous osteonecrosis of tarsal navicular in a 43-year-old male. Chronic midfoot pain over the dorsomedial aspect of the right foot was resolved after complete removal of the necrotic bone from the tarsal navicular, followed by an autologous bone grafting of the resultant defect. (C) 2011 by the American College of Foot and Ankle Surgeons. All rights reserved