The content of cannabinoids in common hemp plants in the conditions of the Republic of Bashkortostan

Cannabis sativa L. – a herbaceous plant. Recently, interest in this fast-growing plant has increased again due to its multipurpose use: It is indeed a treasure trove of phytochemicals and a rich source of both cellulose and wood fibers. The pharmaceutical and construction sectors are equally interested in this plant, since its metabolites have powerful biological activity for human health, and stem outer and inner tissues can be used to manufacture bioplastics and concrete-like materials, respectively. Cannabinoids are the most studied group of compounds, mainly because of their wide range of pharmaceutical effects on the human body, including psychotropic activity. The content of the main cannabinoids in common hemp plants of the Vera, Nadezhda, Surskaya, Omegadar-1 varieties for 2020-2023 has been studied. The predominant cannabinoid in all varieties during the years of the study is CBD. The studied common hemp varieties in the years of research fully comply with the requirements of the law. The THC content did not exceed 0.1%

RURAL YOUTH AS THE SUBJECT OF THE SOCIAL SYSTEM (ON THE EXAMPLE OF THE REPUBLIC OF BASHKOROSTAN)

The article is related to the problems of rural youth of the Republic of Bashkortostan as the subject of the social system. The rural youth acts as the precise indicator of problems in the social sphere, and, first of all, in the agrarian sphere of rural territories of the region. The role of social factors in improvement of economic efficiency of agrarian production is investigated. The authors offer various methods for studying the issue of vital interests of youth living in rural territories

Трансформация сетевого сообщества на разных стадиях жизнедеятельности

На основе многолетних исследований структуры коммуникационных связей сетевых сообществ стало возможным выделить этапы жизнедеятельности и описать виды трансформации связей и некоторые другие метрики сетевого сообщества на каждом из этапов.On the basis of long-term studies of the structure of communication links online communities became possible to identify the stages of life and describe the types of transformation relations and some other network community metrics at each stage

Foundation of Saratov school of craniology and its development at the present stage

The aim of the article is to present to the scientific community the data on the collection of fundamental craniological Museum of Human Anatomy Department of Saratov State Medical University.</p

The role of museum of Department of Human Anatomy in the educational process

The article contains information on the history of the formation of the fundamental educational and scientific museum of Human Anatomy department of Saratov State Medical University n.a. V. I. Razumovsky. The main collections of the fund of anatomy museum are presented. Features of registration and registration of anatomical preparations, as well as the purpose of their exposure, are described. The importance of the museum in the educational and scientific process of the department of human anatomy is considered.</p

Effect of combined lipid-lowering therapy on atherosclerotic plaque vulnerability in patients with acute coronary syndrome (Combi-LLT ACS): randomized trial protocol

Aim. To study the effect of high-dose combined lipid-lowering therapy (statins + ezetimibe vs statins + PCSK9 inhibitors) on plaque vulnerability assessed using multimodal imaging (coronary computed tomography angiography (CCTA) and optical coherence tomography, as well as biomarkers in patients with acute coronary syndrome (ACS).Material and methods. This open, prospective, randomized, single-center study will include 120 patients admitted urgently with an ACS. All patients will undergo percutaneous coronary intervention of the infarct-related artery, as well as intracoronary imaging using optical coherence tomography of one or two noninfarct-related arteries. During hospitalization, patients will receive standard therapy for ACS according to clinical guidelines, while statins will initially be prescribed at a maximum dosage of atorvastatin 80 mg/rosuvastatin 40 mg.Patients who showed high compliance and did not reach the target low-density lipoprotein cholesterol (LDL-C) values (≤1,4 mmol/l) 1 month after myocardial infarction/unstable angina at the second visit will be randomized into two groups. Patients of group 1 will receive PCSK9 inhibitors (alirocumab 150 mg by subcutaneous injection once every 2 weeks or evolocumab 140 mg by subcutaneous injection once every 2 weeks) in addition to maximum statin therapy (atorvastatin 80 mg/rosuvastatin 40 mg), while group 2 participants will take ezetimibe at a dose of 10 mg in combination with the maximum dose of statins. In addition, at the second visit, patients will undergo CCTA, assess the cardio-ankle vascular index (CAVI) index and laboratory tests (complete blood count (neutrophil-to-lymphocyte ratio NLR), lipid profile, alanine aminotransferase (ALT), aspartate aminotransferase (AST), Troponin I, Galectin-3, high-sensitivity C-reactive protein (hs-CRP), metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase 1 (TIMP-1), neutrophil gelatinase-associated lipocalin (NGAL). Total follow-up will last 52 weeks. At the final visit, patients will undergo CCTA, assessment of the CAVI index and laboratory status (NLR, lipid profile, ALT, AST), Troponin I, Galectin-3, hs-CRP, MMP-9, TIMP-1, NGAL).Primary endpoint: reduction in plaque vulnerability according CCTA in non-infarct-related coronary arteries Secondary endpoints: death, stent thrombosis/restenosis, non-fatal myocardial infarction, readmissions with progressive angina, repeat revascularization; changes of the lipid profile (total cholesterol, LDL-C, high-density lipoprotein cholesterol, triglycerides) against the background of maximum combination therapy with statin + PCSK9 inhibitors or statin + ezetimibe; changes of the biomarkers of cardiac injury (Troponin I), inflammation (NLR, hs-CRP, NGAL, Galectin-3) and matrix remodeling (MMP-9, TIMP-1).Conclusion. Our study will allow for the first time to compare and evaluate the effect of both PCSK9 inhibitors and ezetimibe in combination with high-dose statin therapy on reducing the plaque vulnerability according to CCTA in non-infarction-related coronary arteries in patients with ACS undergoing percutaneous coronary intervention, as well as to evaluate the diagnostic value of inflammatory biomarkers (NLR, hs-CRP, NGAL, Galectin-3) and matrix remodeling (MMP-9, TIMP-1)

Yield and quality of hemp seeds in the Republic of Bashkortostan

The article presents data on the results of studies of three hemp cultivars (Vera, Nadezhda, Omegadar-1), conducted in 2021-2022 in the environmental conditions of the southern forest-steppe zone of the Republic of Bashkortostan. Studies have shown the advantage of the Nadezhda cultivar in terms of morphometric parameters, weight of 1000 seeds, oil content, and yield

Apical hypertrophic cardiomyopathy as a mask of acute coronary syndrome: a case series

Apical hypertrophic cardiomyopathy (HCM) or Yamaguchi syndrome is a relatively rare subtype of HCM characterized by a left ventricular apex localization of the hypertrophy. In this case, chest pain can be erroneously interpreted as a manifestation of coronary artery disease. This article presents two cases of apical HCM in patients admitted with a diagnosis of acute coronary syndrome. Electrocardiogram revealed repolarization disorder and giant T wave inversion (up to 10 mm) in the precordial leads. Transthoracic echocardiography revealed local symmetric hypertrophy of the left ventricular apex, which made it possible to diagnose apical HCM. The coronary arteries in both patients were intact. The presented cases demonstrate a variant of apical HCM with chest pain as the leading clinical syndrome, which can often be the cause of overdiagnosis of acute coronary syndrome

Matériaux métal-sulfure pour la conversion de l'éthane en présence de CO2

Ethane processing is a large industrial branch for high-valuable chemicals production. Steam cracking of oil fractions is the major process currently used to produce ethylene. An alternative ethane conversion strategy is the oxidative dehydrogenation of ethane with CO2. Thus, the present study is devoted to oxidative ethane dehydrogenation (ODH-CO2) and ethane dry reforming (DRE). The ethane conversion with CO2 is performed on the principally new types of catalysts - metal sulfides (KGaS2) and metal sulfide-derived carbides, the latter being grafted on embryonic zeolites. Carbides are found to be flexible catalytic systems with tunable properties for ODH-CO2 and DRE. The set of experimental data proves a carbon-negative process with ethylene selectivity (89-98%) and reactants conversion comparable with steam cracking parameters. The PhD thesis also reports the first application of thiogallates for thermal catalysis. The obtained results open new perspectives for thiogallates application as hydrogenation catalysts (ethylene selectivity 87-96%).Le traitement de l'éthane est une grande branche industrielle pour la production de produits chimiques de grande valeur. Le vapocraquage des fractions pétrolières est le principal procédé actuellement utilisé pour produire de l'éthylène. Une autre stratégie de conversion de l'éthane est la déshydrogénation oxydative de l'éthane avec du CO2. Ainsi, la présente étude est consacrée à la déshydrogénation oxydative de l'éthane (ODH-CO2) et au reformage à sec de l'éthane (DRE). La conversion de l'éthane avec le CO2 est effectuée sur les principaux types de catalyseurs nouveaux - les sulfures métalliques (KGaS2) et les carbures dérivés de sulfures métalliques, ces derniers étant greffés sur des zéolithes embryonnaires. Les carbures se révèlent être des systèmes catalytiques flexibles avec des propriétés accordables pour ODH-CO2 et DRE. L'ensemble des données expérimentales prouve un procédé carbone négatif avec une sélectivité en éthylène (89-98%) et une conversion des réactifs comparables aux paramètres de vapocraquage. La thèse de doctorat rapporte également la première application des thiogallates pour la catalyse thermique. Les résultats obtenus ouvrent de nouvelles perspectives pour l'application des thiogallates comme catalyseurs d'hydrogénation (sélectivité éthylène 87-96%)

Matériaux métal-sulfure pour la conversion de l'éthane en présence de CO2

Le traitement de l'éthane est une grande branche industrielle pour la production de produits chimiques de grande valeur. Le vapocraquage des fractions pétrolières est le principal procédé actuellement utilisé pour produire de l'éthylène. Une autre stratégie de conversion de l'éthane est la déshydrogénation oxydative de l'éthane avec du CO2. Ainsi, la présente étude est consacrée à la déshydrogénation oxydative de l'éthane (ODH-CO2) et au reformage à sec de l'éthane (DRE). La conversion de l'éthane avec le CO2 est effectuée sur les principaux types de catalyseurs nouveaux - les sulfures métalliques (KGaS2) et les carbures dérivés de sulfures métalliques, ces derniers étant greffés sur des zéolithes embryonnaires. Les carbures se révèlent être des systèmes catalytiques flexibles avec des propriétés accordables pour ODH-CO2 et DRE. L'ensemble des données expérimentales prouve un procédé carbone négatif avec une sélectivité en éthylène (89-98%) et une conversion des réactifs comparables aux paramètres de vapocraquage. La thèse de doctorat rapporte également la première application des thiogallates pour la catalyse thermique. Les résultats obtenus ouvrent de nouvelles perspectives pour l'application des thiogallates comme catalyseurs d'hydrogénation (sélectivité éthylène 87-96%).Ethane processing is a large industrial branch for high-valuable chemicals production. Steam cracking of oil fractions is the major process currently used to produce ethylene. An alternative ethane conversion strategy is the oxidative dehydrogenation of ethane with CO2. Thus, the present study is devoted to oxidative ethane dehydrogenation (ODH-CO2) and ethane dry reforming (DRE). The ethane conversion with CO2 is performed on the principally new types of catalysts - metal sulfides (KGaS2) and metal sulfide-derived carbides, the latter being grafted on embryonic zeolites. Carbides are found to be flexible catalytic systems with tunable properties for ODH-CO2 and DRE. The set of experimental data proves a carbon-negative process with ethylene selectivity (89-98%) and reactants conversion comparable with steam cracking parameters. The PhD thesis also reports the first application of thiogallates for thermal catalysis. The obtained results open new perspectives for thiogallates application as hydrogenation catalysts (ethylene selectivity 87-96%)