Profiling of major fatty acids in different raw and roasted sesame seeds cultivars

The aim of this study was to investigate the fatty acids profile of five sesame cultivars including Branching Naz, Darab, Karaj, Dezful and Black sesame and the effect of time and temperature roasting procedure. The seeds oil content varied from 43±0.28 to 47±0.41% with the average content of 44.4±1.87%. Darab and Black sesame cultivar had the highest and lowest oil content respectively. Oleic and linoleic acids were the two-dominant fatty acids in the sesame seed oil about 80 to 85% of the total amount, whereas palmitic and stearic acids were present at 12 to 15%. Moreover, Dazful and Black sesame had the maximum and minimum content of oxidizability value respectively. The results of the present study showed that the fatty acid contents in studied cultivars were steady during different roasting conditions and fatty acid behavior of samples was good fitted with the high temperatures.Key words: Gas chromatography (GC), fatty acid, roasting procedure, sesame seed, stability

BOTection: bot detection by building Markov Chain models of bots network behavior

This paper was presented at the 15th ACM ASIA Conference on Computer and Communications Security (ACM ASIACCS 2020), 5-9 October 2020, Taipei, Taiwan. This is the accepted manuscript version of the paper. The final version is available online from the Association for Computing Machinery at: https://doi.org/10.1145/3320269.3372202.Botnets continue to be a threat to organizations, thus various machine learning-based botnet detectors have been proposed. However, the capability of such systems in detecting new or unseen botnets is crucial to ensure its robustness against the rapid evolution of botnets. Moreover, it prolongs the effectiveness of the system in detecting bots, avoiding frequent and time-consuming classifier re-training. We present BOTection, a privacy-preserving bot detection system that models the bot network flow behavior as a Markov Chain. The Markov Chain state transitions capture the bots' network behavior using high-level flow features as states, producing content-agnostic and encryption resilient behavioral features. These features are used to train a classifier to first detect flows produced by bots, and then identify their bot families. We evaluate our system on a dataset of over 7M malicious flows from 12 botnet families, showing its capability of detecting bots' network traffic with 99.78% F-measure and classifying it to a malware family with a 99.09% F-measure. Notably, due to the modeling of general bot network behavior by the Markov Chains, BOTection can detect traffic belonging to unseen bot families with an F-measure of 93.03% making it robust against malware evolution.Accepted manuscrip

An In-vitro Evaluation of the Ability of 5.25% NaOCl in the Elimination of Enterococcus Faecalis from Root Canal

Statement of Problem: Sodium hypochlorite (NaOCl) have been widely used as an irrigant since it has been introduced to endodontics by walker in 1936, because of its bleaching, deodorizing and tissue dissolving properties. It should be used clinically in concentrations of 3% to 5%.Purpose: The aim of this study was to evaluate the effectiveness of the NaOCl to eliminate Enterococcus faecalis (E.f) from root canals in comparison with Normal saline.Materials and Methods: In an interventional study forty freshly extracted single canal human teeth were chosen. They were sectioned at the CEJ, instrumented and Sterilized.Then they were contaminated with E.f solution and incubated. These samples divided intotwo groups randomly. Root canals were irrigated and filled with 5.25% NaOCl for five minutes in group one, and with normal saline in group two. Then samples were obtained from canals with sterile paper points and cultured for four days. The appearance of turbidityin cultured solutions was the indication to of E.F presence. In order to confirm the specific presence of E.F, three complementary microbiologic tests were applied.Results: All cultures obtained from NaOCl group were negative and all of normal saline group were positive.Conclusion: these results indicate the ability of 5.25% NaOCl to eliminate E.F in prepared root canals with wide diameter

Synthesis of barium titanate piezoelectric ceramics for multilayer actuators (MLAs)

In this paper the characteristics of BaTiO3 ceramics synthesized by solid state method is presented. In order to receive the monophase ceramics the double activation and calcination were applied. A spray drier was used to granulate the powder of BaTiO3. Isostatic and uniaxial pressing were applied to manufacture the barium titanate pellets. The properties of fabricated BaTiO3 ceramics were determined at different stages of production. After the sintering phase, the hardness, the bending strength, the fracture toughness, and the coefficient of thermal expansion of barium titanate sinter were estimated. The BaTiO3 powder is characterized by spherical grains and the average size of 0.5 μm. The small value of the specific surface area of granulate ensured good properties of material mouldability and finally allowed to receive sinters of high densit

Multiscale Approach for Modeling Fracture in Piezoelectric Ceramics

The barium titanate material is the most intensively studied perovskite material due to its wide use in the ceramic industry. Barium titanate is also technologically important material owing to its ferroelectric behaviour at and above room temperature. The paper presents an effective implementation of boundary element multiscale method in analyzing of fracture of piezoelectric ceramics. This method can be easily used to get a better understanding of damage mechanism in the ceramic materials in order to improve the constitutive models and to support the future design of those materials. In this method the relation of boundary element method for obtaining traction is presented. The main advantage of boundary element method is the reduction of the dimensionality of the problem. Boundary element method becomes very attractive in cases of numerically complex problems that are computationally expensive

Design and synthesis of 2,4-dioxochroman-pyridinium-phenylacetamide derivatives as new anti-Alzheimer agents: in vitro and in silico studies

2,4-Dioxochroman-pyridinium-phenylacetamide derivatives 7a�n were synthesized and evaluated for their in vitro cholinesterase (ChE) inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Obtained results demonstrated that, among the synthesized compounds, two compounds, 7j and 7k, were more potent than the standard drug donepezil against BuChE and did not show cytotoxicity and carcinogenicity. Furthermore, through molecular modeling and molecular dynamic studies. we showed that these compounds can be located deep in the gorge cavity of BuChE and that they interacted with catalytic residues, acyl, and cholin-binding pockets of this enzyme. Support information. © 2020 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinhei

4-Oxobenzod1,2,3-triazin-pyridinium-phenylacetamide derivatives as new anti-Alzheimer agents: design, synthesis, in vitro evaluation, molecular modeling, and molecular dynamic study

A new series of 4-oxobenzod1,2,3-triazin-pyridinium-phenylacetamide hybrids 8a�p was designed, synthesized, and screened as the potential cholinesterase inhibitors against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Obtained anti-cholinesterase activities demonstrated that all the title compounds exhibited excellent inhibition against BuChE and moderate inhibitory activity toward AChE in comparison to standard cholinesterase inhibitor donepezil. For example, compound 8e exhibited about 49-fold higher inhibitory activity than donepezil (IC50 = 3.2 ± 0.3 μM) against BuChE. This compound inhibited BuChE via a mixed-type inhibition mode. This finding demonstrated that compound 8e in addition to catalytic anionic site (CAS) can also interact with the peripheral anionic site (PAS) of BuChE. Molecular modeling and molecular dynamic studies were also performed on synthesized compounds. © 2020, Springer Science+Business Media, LLC, part of Springer Nature

New 1,2,3-triazole�(thio)barbituric acid hybrids as urease inhibitors: Design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation

A new series of 1,2,3-triazole�(thio)barbituric acid hybrids 8a�n was designed and synthesized on the basis of potent pharmacophores with urease inhibitory activity. Therefore, these compounds were evaluated against Helicobacter pylori urease. The obtained result demonstrated that all the synthesized compounds, 8a�n, were more potent than the standard urease inhibitor, hydroxyurea. Moreover, among them, compounds 8a, 8c�e, 8g,h, and 8k,l exhibited higher urease inhibitory activities than the other standard inhibitor used: thiourea. Docking studies were performed with the synthesized compounds. Furthermore, molecular dynamic simulation of the most potent compounds, 8e and 8l, showed that these compounds interacted with the conserved residues Cys592 and His593, which belong to the active site flap and are essential for enzymatic activity. These interactions have two consequences: (a) blocking the movement of a flap at the entrance of the active site channel and (b) stabilizing the closed active site flap conformation, which significantly reduces the catalytic activity of urease. Calculation of the physicochemical and topological properties of the synthesized compounds 8a�n predicted that all these compounds can be orally active. The ADME prediction of compounds 8a�n was also performed. © 2020 Deutsche Pharmazeutische Gesellschaf

Synthesis, Biological Evaluation and Molecular Docking of Deferasirox and Substituted 1,2,4-Triazole Derivatives as Novel Potent Urease Inhibitors: Proposing Repositioning Candidate

A series of new deferasirox derivatives were synthesized through the reaction of monosubstituted hydrazides with 2-(2-hydroxyphenyl)-4H-benzoe1,3oxazin-4-one. For the first time, deferasirox and some of its derivatives were evaluated for their in vitro inhibitory activity against Jack bean urease. The potencies of the members of this class of compounds are higher than that of acetohydroxamic acid. Two compounds, bearing tetrazole and hydrazine derivatives (bioisoester of carboxylate group), represented the most potent urease inhibitory activity with IC50 values of 1.268 and 3.254 μm, respectively. In silico docking studies were performed to delineate possible binding modes of the compounds with the enzyme, urease. Docking analysis suggests that the synthesized compounds were anchored well in the catalytic site and extending to the entrance of binding pocket and thus restrict the mobility of the flap by interacting with its crucial amino acid residues, CME592 and His593. The overall results of urease inhibition have shown that these target compounds can be further optimized and developed as a lead skeleton for the discovery of novel urease inhibitors. © 2020 Wiley-VHCA AG, Zurich, Switzerlan