26 research outputs found
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Immunotherapy of metastatic melanoma by reversal of immune suppression
Beginning with the observation that the human enteorvirus, Poliovirus Sabin 1, will lyse human melanoma cells in culture, clinical trials involving two patients with advance melanoma were performed. Parenteral injection of the viable Poliovirus into cutaneous melanoma metastases followed in 24 hours by oral administration of cyclophosphamide. The results of these two trials are described
Provisioning systems for a good life within planetary boundaries
The concept of provisioning systems has recently emerged as a promising way to understand the differences between levels of resource use and social outcomes observed across societies. However, the characteristics of provisioning systems remain poorly understood. Here, we make a new contribution to conceptualising provisioning systems and to understanding differences in the resource efficiency with which they achieve social outcomes. We define a provisioning system as a set of related elements that work together in the transformation of resources to satisfy a foreseen human need. We analyse six theories in terms of their contribution to understanding provisioning systems within the biophysical and social constraints of Raworth’s “Safe and Just Space” framework. We find that most of these theories fail to prioritise human needs and well-being, and do not incorporate explicit environmental limits. However, they provide important insights that we draw upon to identify six important provisioning system elements (households, markets, the commons, the state, techniques, and material stocks). Based on the theories, we also identify two important relationships between elements, namely feedbacks and power relations. We further propose the concept of “appropriating systems” as a component of provisioning systems. Appropriating systems reduce the resource efficiency of human well-being via rent extraction, and act as a barrier to meeting human needs at a sustainable level of resource use. We combine these concepts into a new framework, and discuss applications to energy systems
METABOLISM OF RADIOACTIVE CHOLESTEROL IN THE INTACT RAT
Photo shows the exterior of St. John's Church, "important cultural property", (Gojo Kawaramachi-dori, Shimogyou-ku, Kyoto, built in 1907), The Museum Meiji-Mura, Inuyama, JapanSt. Johns Church, Meiji Mura, Inuyama, Japan
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Current status of curium inhalation exposures in humans
The maximum permissible amount of alpha-emitting curium in the human body ranges from 0.01 to 1 millimicrogram. Inhalation presents the greatest occupational risk. Since curium has but recently become available in quantities approaching a gram, its metabolism is known almost solely by analogy with plutonium and closely related elements. An incident is described concerning a curium accelerator target aerosolized by explosion. Management of the spill, sampling, particle sizing, and medical findings are presented. Seven of the 27 persons present showed low levels of curium excretion. The data from this incident were compared with those from three other inhalation exposures to curium compounds at this Laboratory