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Synthesis and Study of Olefin Metathesis Catalysts Supported by Redox-Switchable Diaminocarbene 3 Ferrocenophanes
A redox-switchable ligand, N,N'-dimethyldiaminocarbene[3]ferrocenophane (5), was synthesized and incorporated into a series of Ir- and Ru-based complexes. Electrochemical and spectroscopic analyses of (5) Ir(CO)(2)Cl (15) revealed that 5 displayed a Tolman electronic parameter value of 2050 cm(-1) in the neutral state and 2061 cm(-1) upon oxidation. Moreover, inspection of X-ray crystallography data recorded for (5) Ir(cis,cis-1,5-cyclooctadiene)Cl (13) revealed that 5 was sterically less bulky (%V-Bur = 28.4) than other known diaminocarbene[3]ferrocenophanes, which facilitated the synthesis of (5)(PPh3)Cl2Ru-(3-phenylindenylid-1-ene) (18). Complex 18 exhibited quasi-reversible electrochemical processes at 0.79 and 0.98 V relative to SCE, which were assigned to the Fe and Ru centers in the complex, respectively, based on UV-vis and electron pair resonance spectroscopic measurements. Adding 2,3-dichloro-5,6-dicyanoquinone over the course of a ring-opening metathesis polymerization of cis, cis-1,5-cyclooctadiene catalyzed by 18 ([monomer](0)/[18](0) = 2500) reduced the corresponding rate constant of the reaction by over an order of magnitude (pre-oxidation: k(obs) = 0.045 s(-1); post-oxidation: k(obs) = 0.0012 s(-1)). Subsequent reduction of the oxidized species using decamethylferrocene restored catalytic activity (post-reduction: k(obs) = up to 0.016 s(-1), depending on when the reductant was added). The difference in the polymerization rates was attributed to the relative donating ability of the redox-active ligand (i.e., strongly donating 5 versus weakly donating 5(+)) which ultimately governed the activity displayed by the corresponding catalyst.U. S. Army Research Office W911NF-09-1-0446Chemistr
Inversion symmetric 3-monopoles and the Atiyah-Hitchin manifold
We consider 3-monopoles symmetric under inversion symmetry. We show that the
moduli space of these monopoles is an Atiyah-Hitchin submanifold of the
3-monopole moduli space. This allows what is known about 2-monopole dynamics to
be translated into results about the dynamics of 3-monopoles. Using a numerical
ADHMN construction we compute the monopole energy density at various points on
two interesting geodesics. The first is a geodesic over the two-dimensional
rounded cone submanifold corresponding to right angle scattering and the second
is a closed geodesic for three orbiting monopoles.Comment: latex, 22 pages, 2 figures. To appear in Nonlinearit
New hyper-Kaehler manifolds by fixing monopoles
The construction of new hyper-Kaehler manifolds by taking the infinite
monopole mass limit of certain Bogomol'nyi-Prasad-Sommerfield monopole moduli
spaces is considered. The one-parameter family of hyperkaehler manifolds due to
Dancer is shown to be an example of such manifolds. A new family of fixed
monopole spaces is constructed. They are the moduli spaces of four SU(4)
monopoles, in the infinite mass limit of two of the monopoles. These manifolds
are shown to be nonsingular when the fixed monopole positions are distinct.Comment: Version in Phys. Rev. D. 11 pp, RevTeX, 14 Postscript diagram
Chaos in free electron laser oscillators
The chaotic nature of a storage-ring Free Electron Laser (FEL) is
investigated. The derivation of a low embedding dimension for the dynamics
allows the low-dimensionality of this complex system to be observed, whereas
its unpredictability is demonstrated, in some ranges of parameters, by a
positive Lyapounov exponent. The route to chaos is then explored by tuning a
single control parameter, and a period-doubling cascade is evidenced, as well
as intermittence.Comment: Accepted in EPJ
Real-time and Multichannel Measurement of Contractility of hiPSC-Derived 3D Skeletal Muscle using Fiber Optics-Based Sensing
As the field of cardiac and skeletal muscle tissue engineering expands, so does the need for accurate and reliable systems to generate in vitro 3D tissues and analyze their functional properties. In this study, the Cuore is introduced, a system that integrates sensors based on optical fibers and uses the principle of light interferometry to detect the contraction of 3D Tissue Engineered Skeletal Muscles (3D-TESMs). The technology employed in the Cuore allows for reproducible and multichannel force measurements down to a nano-Newtons resolution while maintaining sterility and permitting continuous non-invasive recording within and outside standard tissue culture incubators. Thanks to the integrated electrodes for electrical pulse stimulation (EPS), 3D-TESMs generated from three independent hiPSC-derived myogenic progenitors (MPs) lines are stimulated and the contractility is recorded over the course of a week. Through the modulation of different EPS parameters, the optimal combination to induce the 3D-TESMs in producing fully fused tetani without causing damage is determined. Furthermore, 3D-TESMs from different lines exhibit characteristic signatures of spontaneous contractility and response to caffeine, verapamil, and the β-agonist clenbuterol. The ease of use, high sensitivity, and the integrated electrodes and sensors make the Cuore an ideal technology to investigate the biology of contractile tissues and their response to drugs.</p
Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents
Nanoparticles containing fluorine-18 were prepared from block copolymers made by ring opening metathesis polymerization (ROMP). Using the fast initiating ruthenium metathesis catalyst (H_2IMes)(pyr)_2(Cl)_2Ru=CHPh, low polydispersity amphiphilic block copolymers were prepared from a cinnamoyl-containing hydrophobic norbornene monomer and a mesyl-terminated PEG-containing hydrophilic norbornene monomer. Self-assembly into micelles and subsequent cross-linking of the micelle cores by light-activated dimerization of the cinnamoyl groups yielded stable nanoparticles. Incorporation of fluorine-18 was achieved by nucleophilic displacement of the mesylates by the radioactive fluoride ion with 31% incorporation of radioactivity. The resulting positron-emitting nanoparticles are to be used as in vivo molecular imaging agents for use in tumor imaging
Time--delay autosynchronization of the spatio-temporal dynamics in resonant tunneling diodes
The double barrier resonant tunneling diode exhibits complex spatio-temporal
patterns including low-dimensional chaos when operated in an active external
circuit. We demonstrate how autosynchronization by time--delayed feedback
control can be used to select and stabilize specific current density patterns
in a noninvasive way. We compare the efficiency of different control schemes
involving feedback in either local spatial or global degrees of freedom. The
numerically obtained Floquet exponents are explained by analytical results from
linear stability analysis.Comment: 10 pages, 16 figure
M-theory on `toric' G_2 cones and its type II reduction
We analyze a class of conical G_2 metrics admitting two commuting isometries,
together with a certain one-parameter family of G_2 deformations which
preserves these symmetries. Upon using recent results of Calderbank and
Pedersen, we write down the explicit G_2 metric for the most general member of
this family and extract the IIA reduction of M-theory on such backgrounds, as
well as its type IIB dual. By studying the asymptotics of type II fields around
the relevant loci, we confirm the interpretation of such backgrounds in terms
of localized IIA 6-branes and delocalized IIB 5-branes. In particular, we find
explicit, general expressions for the string coupling and R-R/NS-NS forms in
the vicinity of these objects. Our solutions contain and generalize the field
configurations relevant for certain models considered in recent work of Acharya
and Witten.Comment: 45 pages, references adde
Randomizing world trade. II. A weighted network analysis
Based on the misleading expectation that weighted network properties always
offer a more complete description than purely topological ones, current
economic models of the International Trade Network (ITN) generally aim at
explaining local weighted properties, not local binary ones. Here we complement
our analysis of the binary projections of the ITN by considering its weighted
representations. We show that, unlike the binary case, all possible weighted
representations of the ITN (directed/undirected, aggregated/disaggregated)
cannot be traced back to local country-specific properties, which are therefore
of limited informativeness. Our two papers show that traditional macroeconomic
approaches systematically fail to capture the key properties of the ITN. In the
binary case, they do not focus on the degree sequence and hence cannot
characterize or replicate higher-order properties. In the weighted case, they
generally focus on the strength sequence, but the knowledge of the latter is
not enough in order to understand or reproduce indirect effects.Comment: See also the companion paper (Part I): arXiv:1103.1243
[physics.soc-ph], published as Phys. Rev. E 84, 046117 (2011
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