Linkage between Accretion Disks and Blazars

The magnetic field in an accretion disk is estimated assuming that all of the angular momentum within prescribed accretion disk radii is removed by a jet. The magnetic field estimated at the base of the jet is extrapolated to the blazar emission region using a model for a relativistic axisymmetric jet combined with some simplifying assumptions based on the relativistic nature of the flow. The extrapolated magnetic field is compared with estimates based upon the synchrotron and inverse Compton emission from three blazars, MKN 501, MKN 421 and PKS 2155-304. The magnetic fields evaluated from pure synchrotron self- Compton models are inconsistent with the magnetic fields extrapolated in this way. However, in two cases inverse Compton models in which a substantial part of the soft photon field is generated locally agree well, mainly because these models imply magnetic field strengths which are closer to being consistent with Poynting flux dominated jets. This comparison is based on estimating the mass accretion rate from the jet energy flux. Further comparisons along these lines will be facilitated by independent estimates of the mass accretion rate in blazars and by more detailed models for jet propagation near the black hole.Comment: Submiteed to the Astrophysics & Space Science special issue on the 5th Stromlo Symposiu

Towards a New Standard Theory for Astrophysical Disk Accretion

We briefly review recent developments in black hole accretion disk theory, placing new emphasis on the vital role played by magnetohydrodynamic (MHD) stresses in transporting angular momentum. The apparent universality of accretion-related outflow phenomena is a strong indicator that vertical transport of angular momentum by large-scale MHD torques is important and may even dominate radial transport by small-scale MHD turbulence. This leads to an enhanced overall rate of angular momentum transport and allows accretion of matter to proceed at an interesting rate. Furthermore, we argue that when vertical transport is important, the radial structure of the accretion disk is modified and this affects the disk emission spectrum. We present a simple model demonstrating that energetic, magnetically-driven outflows give rise to a disk spectrum that is dimmer and redder than a standard accretion disk accreting at the same rate. We briefly discuss the implications of this key result for accreting black holes in different astrophysical systems.Comment: Accepted for publication as brief review in Mod. Phys. Let.

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox

Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases. It is associated with an incredibly complex pathophysiology due to the vast number of unique toxins/proteins found in the venoms of diverse snake species found worldwide. Here, we report the purification and functional characteristics of a group I metalloprotease (CAMP-2) from the venom of the western diamondback rattlesnake, Crotalus atrox. Its sensitivity to matrix metalloprotease inhibitors (batimastat and marimastat) was established using specific in vitro experiments and in silico molecular docking analysis. CAMP-2 shows high sequence homology to atroxase from the venom of Crotalus atrox and exhibits collagenolytic, fibrinogenolytic and mild haemolytic activities. It exerts a mild inhibitory effect on agonist-induced platelet aggregation in the absence of plasma proteins. Its collagenolytic activity was completely inhibited by batimastat and marimastat. Zinc chloride also inhibits the collagenolytic activity of CAMP-2 by around 75% at 50 M, while it is partially potentiated by calcium chloride. Molecular docking studies demonstrate that batimastat and marimastat are able to bind strongly to the active site residues of CAMP-2. This study demonstrates the impact of matrix metalloprotease inhibitors in the modulation of a purified, group I metalloprotease activities in comparison to the whole venom. By improving our understanding of snake venom metalloproteases and their sensitivity to small molecule inhibitors, we can begin to develop novel and improved treatment strategies for snakebites

Challenges in diagnosing and treating snakebites in a rural population of Tamil Nadu, India: the views of clinicians

Snakebites cause death, disability and economic devastation to their victims, people who live almost exclusively in rural areas. Annually an estimated two million venomous bites cause as many as 100,000 deaths worldwide as well as hundreds of thousands of deformities and amputations. Recent studies suggest that India has the highest incidence of snakebite and associated deaths worldwide. In this study, we interviewed 25 hospital-based clinicians who regularly treat snakebites in Tamil Nadu, India, in order to gauge their opinions and views on the diagnostic tools and treatment methods available at that time, the difficulties encountered in treating snakebites and improvements to snakebite management protocols they deem necessary. Clinicians identified the improvement of community education, training of medical personnel, development of standard treatment protocols and improved medication as priorities for the immediate future

What is Normalization? The Strategies Employed in Top-Down and Bottom-Up Proteome Analysis Workflows.

The accurate quantification of changes in the abundance of proteins is one of the main applications of proteomics. The maintenance of accuracy can be affected by bias and error that can occur at many points in the experimental process, and normalization strategies are crucial to attempt to overcome this bias and return the sample to its regular biological condition, or normal state. Much work has been published on performing normalization on data post-acquisition with many algorithms and statistical processes available. However, there are many other sources of bias that can occur during experimental design and sample handling that are currently unaddressed. This article aims to cast light on the potential sources of bias and where normalization could be applied to return the sample to its normal state. Throughout we suggest solutions where possible but, in some cases, solutions are not available. Thus, we see this article as a starting point for discussion of the definition of and the issues surrounding the concept of normalization as it applies to the proteomic analysis of biological samples. Specifically, we discuss a wide range of different normalization techniques that can occur at each stage of the sample preparation and analysis process

Equation of state and transport processes in self--similar spheres

We study the effect of transport processes (diffusion and free--streaming) on a collapsing spherically symmetric distribution of matter in a self--similar space--time. A very simple solution shows interesting features when it is matched with the Vaidya exterior solution. In the mixed case (diffusion and free--streaming), we find a barotropic equation of state in the stationary regime. In the diffusion approximation the gravitational potential at the surface is always constant; if we perturb the stationary state, the system is very stable, recovering the barotropic equation of state as time progresses. In the free--streaming case the self--similar evolution is stationary but with a non--barotropic equation of state.Comment: 9 pages, 2 figure

One More Awareness Gap? The Behaviour–Impact Gap Problem

Preceding research has made hardly any attempt to measure the ecological impacts of pro-environmental behaviour in an objective way. Those impacts were rather supposed or calculated. The research described herein scrutinized the ecological impact reductions achieved through pro-environmental behaviour and raised the question how much of a reduction in carbon footprint can be achieved through voluntary action without actually affecting the socio-economic determinants of life. A survey was carried out in order to measure the difference between the ecological footprint of “green” and “brown” consumers. No significant difference was found between the ecological footprints of the two groups—suggesting that individual pro-environmental attitudes and behaviour do not always reduce the environmental impacts of consumption. This finding resulted in the formulation of a new proposition called the BIG (behaviour–impact gap) problem, which is an interesting addition to research in the field of environmental awareness gaps

Progress in understanding Blazars from BeppoSAX observations

Results obtained with BeppoSAX observations of blazars within various collaborative programs are presented. The spectral similarity "paradigm", whereby the spectral energy distributions of blazars follow a sequence, leading to a unified view of the whole population, is briefly illustrated. We concentrate on recent observations of flares and associated spectral variability for three objects at the "blue" end of the spectral sequence, namely PKS 2155-304, Mkn 421 and Mkn 501. The results are discussed in terms of a general analytic synchrotron self-Compton interpretation of the overall spectrum. The physical parameters of the quasi-stationary emission region can be derived with some confidence, while the variability mechanism(s) must be complex.Comment: 10 pages, 8 figures, to be published in the Proceedings of the 32nd COSPAR Meeting, Nagoya, 12-19 July 199

Convergence to a self-similar solution in general relativistic gravitational collapse

We study the spherical collapse of a perfect fluid with an equation of state $P=k\rho$ by full general relativistic numerical simulations. For 0, it has been known that there exists a general relativistic counterpart of the Larson-Penston self-similar Newtonian solution. The numerical simulations strongly suggest that, in the neighborhood of the center, generic collapse converges to this solution in an approach to a singularity and that self-similar solutions other than this solution, including a ``critical solution'' in the black hole critical behavior, are relevant only when the parameters which parametrize initial data are fine-tuned. This result is supported by a mode analysis on the pertinent self-similar solutions. Since a naked singularity forms in the general relativistic Larson-Penston solution for 0, this will be the most serious known counterexample against cosmic censorship. It also provides strong evidence for the self-similarity hypothesis in general relativistic gravitational collapse. The direct consequence is that critical phenomena will be observed in the collapse of isothermal gas in Newton gravity, and the critical exponent $\gamma$ will be given by $\gamma\approx 0.11$, though the order parameter cannot be the black hole mass.Comment: 22 pages, 15 figures, accepted for publication in Physical Review D, reference added, typos correcte