The East Midlands in 2010: introduction

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. It presents a statistical portrait of the region covering demography, housing, economy & productivity, the labour market, deprivation & economic inclusion, transport, infrastructure & development, the environment and the spatial structure of the economy along with a series of sub-regional profiles. This document is the introduction

The East Midlands in 2010: executive summary

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. It presents a statistical portrait of the region covering demography, housing, economy & productivity, the labour market, deprivation & economic inclusion, transport, infrastructure & development, the environment and the spatial structure of the economy along with a series of sub-regional profiles. This document is the executive summary

The East Midlands in 2010: the spatial economy of the East Midlands

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. This document presents detailed analysis of the spatial economy of the East Midlands

The East Midlands in 2006: economy and productivity

The East Midlands in 2006 is the evidence base that was produced to underpin the devleopment of the regional economic strategy, A Flourishing Region. This document presents detailed analysis of the economy of the East Midlands.

The East Midlands in 2006: deprivation and inclusion

The East Midlands in 2006 is the evidence base that was produced to underpin the development of the regional economic strategy, A Flourishing Region. This document presents detailed analysis of deprivation and economic inclusion in the East Midlands.

The East Midlands in 2010

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. It presents a statistical portrait of the region covering demography, housing, economy & productivity, the labour market, deprivation & economic inclusion, transport, infrastructure & development, the environment and the spatial structure of the economy along with a series of sub-regional profiles

The East Midlands in 2006: the East Midlands environment

The East Midlands in 2006 is the evidence base that was produced to underpin the development of the regional economic strategy, A Flourishing Region. This document presents detailed analysis of the environment of the East Midlands.

The East Midlands in 2010: economy

The East Midlands in 2010 is the updated evidence base that supports the regional economic strategy, A Flourishing Region. This document presents detailed analysis of the economy of the East Midlands

The East Midlands in 2006: transport, infrastructure and development

The East Midlands in 2006 is the evidence base that was produced to underpin the development of the regional economic strategy, A Flourishing Region. This document presents detailed analysis of transport, infrastructure and development in the East Midlands.

Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.

Protein-protein interactions (PPIs) are of pivotal importance in the regulation of biological systems and are consequently implicated in the development of disease states. Recent work has begun to show that, with the right tools, certain classes of PPI can yield to the efforts of medicinal chemists to develop inhibitors, and the first PPI inhibitors have reached clinical development. In this Review, we describe the research leading to these breakthroughs and highlight the existence of groups of structurally related PPIs within the PPI target class. For each of these groups, we use examples of successful discovery efforts to illustrate the research strategies that have proved most useful.JS, DES and ARB thank the Wellcome Trust for funding.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/nrd.2016.2