Adversarial Sparse-View CBCT Artifact Reduction

We present an effective post-processing method to reduce the artifacts from sparsely reconstructed cone-beam CT (CBCT) images. The proposed method is based on the state-of-the-art, image-to-image generative models with a perceptual loss as regulation. Unlike the traditional CT artifact-reduction approaches, our method is trained in an adversarial fashion that yields more perceptually realistic outputs while preserving the anatomical structures. To address the streak artifacts that are inherently local and appear across various scales, we further propose a novel discriminator architecture based on feature pyramid networks and a differentially modulated focus map to induce the adversarial training. Our experimental results show that the proposed method can greatly correct the cone-beam artifacts from clinical CBCT images reconstructed using 1/3 projections, and outperforms strong baseline methods both quantitatively and qualitatively

The σHβ\sigma_{\rm H\beta}-based dimensionless accretion rate and its connection with the corona for AGN

With respect to the $\rm H\beta$ full width at half-maximum ($\rm FWHM_{H\beta}$), the broad $\rm H\beta$ line dispersion ($\sigma_{\rm H\beta}$) was preferred as a velocity tracer to calculate the single-epoch supermassive black hole mass ($M_{\rm BH}$) suggested by \cite{Yu2020b}. For a compiled sample of 311 broad-line active galactic nuclei (AGN) with measured hard X-ray photon index ($z<0.7$), $\sigma_{\rm H\beta}$ and the optical Fe II relative strength ($R_{\rm Fe}$) are measured from their optical spectra, which are used to calculate $\sigma_{\rm H\beta}$-based virial $M_{\rm BH}$ and dimensionless accretion rate ($\dot{\mathscr{M}}$). With respect to $\rm FWHM_{\rm H\beta}$, it is found that the mean value of $\sigma_{\rm H\beta}$-based $M_{\rm BH}$ is on average larger by 0.26 dex, and the mean value of $\sigma_{\rm H\beta}$-based $\dot{\mathscr{M}}$ is on average smaller by 0.51 dex. It is found that there exists a non-linear relationship between the Eddington ratio ($L_{\rm Bol}/L_{\rm Edd}$) and $\dot{\mathscr{M}}$, i.e., $L_{\rm Bol}/L_{\rm Edd} \propto \dot{\mathscr{M}}^{0.56\pm 0.01}$. This non-linear relationship comes from the accretion efficiency $\eta$, which is smaller for AGN with higher $\dot{\mathscr{M}}$. We find a strong bivariate correlation of the fraction of energy released in the corona $F_{\rm X}$ with $\dot{\mathscr{M}}$ and \mbh, $F_{\rm X} \propto \dot{\mathscr{M}}^{-0.57\pm 0.05} M_{\rm BH}^{-0.54\pm 0.06}$. The flat slope of $-0.57\pm 0.05$ favours the shear stress tensor of the accretion disk being proportional to the geometric mean of gas pressure and total pressure. We find a strong bivariate relation of $\Gamma$ with $\dot{\mathscr{M}}$ and $F_{\rm X}$, $\Gamma \propto \dot{\mathscr{M}}^{-0.21\pm 0.02}F_{\rm X}^{0.02\pm 0.04}$. The hard X-ray spectrum becomes softer with increasing of $F_{\rm X}$, although the scatter is large.Comment: 18 pages, 9 figures, ApJ, in pres

GAP: From sound design to practical implementation in clinical trials for traditional chinese medicine

The past few years have witnessed encouraging progress in improving the methodological quality of clinical research of traditional Chinese medicine (TCM). This improvement has contributed to wider academic acceptance of the findings of TCM clinical studies, which were previously deemed dubious. As a proof of this statement, one clinical study testing the effects of a Chinese patent drug Qili Qiangxin Capsules on chronic heart failure has just published a research article on the Journal of the American College of Cardiology, a medical journal of international prestige. However, a sound and scientific design does not always see to its practicality in the conduct of the study, and in fact we observed a widening gap between the two elements. In this special issue, we called for papers discussing efforts to bridge the gap between scientific design and practical implementation of clinical research with TCM

Melt conditioning by advanced shear technology (MCAST) for refining solidification microstructures

MCAST (melt conditioning by advanced shear technology) is a novel processing technology developed recently by BCAST at Brunel University for conditioning liquid metal prior to solidification processing. The MCAST process uses a twin screw mechanism to impose a high shear rate and a high intensity of turbulence to the liquid metal, so that the conditioned liquid metal has uniform temperature, uniform chemical composition and well-dispersed and completely wetted oxide particles with a fine size and a narrow size distribution. The microstructural refinement is achieved through an enhanced heterogeneous nucleation rate and an increased nuclei survival rate during the subsequent solidification processing. In this paper we present the MCAST process and its applications for microstructural refinement in both shape casting and continuous casting of light alloys

Reconsideration of Second Harmonic Generation from neat Air/Water Interface: Broken of Kleinman Symmetry from Dipolar Contribution

It has been generally accepted that there are significant quadrupolar and bulk contributions to the second harmonic generation (SHG) reflected from the neat air/water interface, as well as common liquid interfaces. Because there has been no general methodology to determine the quadrupolar and bulk contributions to the SHG signal from a liquid interface, this conclusion was reached based on the following two experimental phenomena. Namely, the broken of the macroscopic Kleinman symmetry, and the significant temperature dependence of the SHG signal from the neat air/water interface. However, because sum frequency generation vibrational spectroscopy (SFG-VS) measurement of the neat air/water interface observed no apparent temperature dependence, the temperature dependence in the SHG measurement has been reexamined and proven to be an experimental artifact. Here we present a complete microscopic analysis of the susceptibility tensors of the air/water interface, and show that dipolar contribution alone can be used to address the issue of broken of the macroscopic Kleinman symmetry at the neat air/water interface. Using this analysis, the orientation of the water molecules at the interface can be obtained, and it is consistent with the measurement from SFG-VS. Therefore, the key rationales to conclude significantly quadrupolar and bulk contributions to the SHG signal of the neat air/water interface can no longer be considered as valid as before. This new understanding of the air/water interface can shed light on our understanding of the nonlinear optical responses from other molecular interfaces as well