A reference map of the human binary protein interactome.

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes

Assessment of the Summer South Asian High in Eighteen CMIP5 Models

The South Asian High (SAH) is one of the most important components of the Asian summer monsoon system. To understand the ability of state-of-the-art general circulation models (GCMs) to capture the major characteristics of the SAH, the authors evaluate 18 atmospheric models that participated in the Coupled Model Intercomparison Project Phase 5/Atmospheric Model Intercomparison Project (CMIP5/AMIP). Results show that the multi-model ensemble (MME) mean is able to capture the climatological pattern of the SAH, although its intensity is slightly underestimated. For the interannual variability of the SAH, the MME exhibits good correlation with the reanalysis for the area and intensity index, but poor skill in capturing the east-west oscillation of the SAH. For the interdecadal trend, the MME shows pronounced increasing trends from 1985 to 2008 for the area and intensity indexes, which is consistent with the reanalysis, but fails to capture the westward shift of the SAH center. The individual models show different capacities for capturing climatological patterns, interannual variability, and interdecadal trends of the SAH. Several models fail to capture the climatological pattern, while one model overestimates the intensity of the SAH. Most of the models show good correlations for interannual variability, but nearly half exhibit high root-mean-square difference (RMSD) values. Six models successfully capture the westward shift of the SAH center in the interdecadal trends, while other models fail. The possible causes of the systematic biases involved in several models are also discussed.</p

Seabed Liquefaction around Pipeline with Backfilling Trench Subjected to Strong Earthquake Motions

As an indispensable part of the lifeline for the offshore gas and oil industry, submarine pipelines under long-term marine environmental loadings have historically been susceptible to earthquakes. This study investigates the impact of trench backfilling on the residual liquefaction around a pipeline and the induced uplift of a pipeline under the combined action of an earthquake, ocean wave and current loading. A fully coupled nonlinear effective stress analysis method, which can consider the nonlinear hysteresis and the large deformation after liquefaction of the seabed soil, is adopted to describe the interaction between the seabed soil and the submarine pipeline. Taking a typical borehole in the Bohai strait as the site condition, the nonlinear seismic response analysis of the submarine pipeline under the combined action of seismic loading and ocean wave and current is carried out. The numerical results show that trench backfilling has a significant impact on the seismic response of the pipeline. The existence of trench backfilling reduces the accumulation of the residual excess pore water pressure, so that the seabed liquefaction around the pipeline is mitigated and the uplift of the pipeline is also decreased

Seabed Liquefaction around Pipeline with Backfilling Trench Subjected to Strong Earthquake Motions

As an indispensable part of the lifeline for the offshore gas and oil industry, submarine pipelines under long-term marine environmental loadings have historically been susceptible to earthquakes. This study investigates the impact of trench backfilling on the residual liquefaction around a pipeline and the induced uplift of a pipeline under the combined action of an earthquake, ocean wave and current loading. A fully coupled nonlinear effective stress analysis method, which can consider the nonlinear hysteresis and the large deformation after liquefaction of the seabed soil, is adopted to describe the interaction between the seabed soil and the submarine pipeline. Taking a typical borehole in the Bohai strait as the site condition, the nonlinear seismic response analysis of the submarine pipeline under the combined action of seismic loading and ocean wave and current is carried out. The numerical results show that trench backfilling has a significant impact on the seismic response of the pipeline. The existence of trench backfilling reduces the accumulation of the residual excess pore water pressure, so that the seabed liquefaction around the pipeline is mitigated and the uplift of the pipeline is also decreased

Reducing Carbon Emissions from Prefabricated Decoration: A Case Study of Residential Buildings in China

Since decoration is an essential part of buildings, the carbon emissions generated by decoration work should not be ignored. In recent years, prefabricated decoration has attracted much attention as efforts are made to pursue green, low-carbon, and waste-reducing buildings. However, research on carbon emissions assessment of prefabricated buildings has focused mainly on the structural aspect of prefabricated buildings, with few studies having considered prefabricated decoration. This study therefore focuses on assessing the carbon emissions of prefabricated decoration from the life cycle perspective of a case study residential building and explores the potential for reducing carbon emissions by decorating buildings with prefabricated components. The results show that using prefabricated decoration in the case study building reduced carbon emissions by 29.08% at the building material production stage compared to traditional decoration, and using an optimized design of prefabricated decoration, the building’s energy consumption over its design life could reduce carbon emissions by 1046 kgCO2/m2. These findings demonstrate the benefits of prefabrication decoration for reducing carbon emissions. This study provides decoration companies with robust data and insights to guide future decisions and practices, helping to transform and achieve the carbon neutrality goal for the building decoration industry