Multi-GradSpeech: Towards Diffusion-based Multi-Speaker Text-to-speech Using Consistent Diffusion Models

Recent advancements in diffusion-based acoustic models have revolutionized data-sufficient single-speaker Text-to-Speech (TTS) approaches, with Grad-TTS being a prime example. However, diffusion models suffer from drift in training and sampling distributions due to imperfect score-matching. The sampling drift problem leads to these approaches struggling in multi-speaker scenarios in practice. In this paper, we present Multi-GradSpeech, a multi-speaker diffusion-based acoustic models which introduces the Consistent Diffusion Model (CDM) as a generative modeling approach. We enforce the consistency property of CDM during the training process to alleviate the sampling drift problem in the inference stage, resulting in significant improvements in multi-speaker TTS performance. Our experimental results corroborate that our proposed approach can improve the performance of different speakers involved in multi-speaker TTS compared to Grad-TTS, even outperforming the fine-tuning approach. Audio samples are available at https://welkinyang.github.io/multi-gradspeech

Expressive-VC: Highly Expressive Voice Conversion with Attention Fusion of Bottleneck and Perturbation Features

Voice conversion for highly expressive speech is challenging. Current approaches struggle with the balancing between speaker similarity, intelligibility and expressiveness. To address this problem, we propose Expressive-VC, a novel end-to-end voice conversion framework that leverages advantages from both neural bottleneck feature (BNF) approach and information perturbation approach. Specifically, we use a BNF encoder and a Perturbed-Wav encoder to form a content extractor to learn linguistic and para-linguistic features respectively, where BNFs come from a robust pre-trained ASR model and the perturbed wave becomes speaker-irrelevant after signal perturbation. We further fuse the linguistic and para-linguistic features through an attention mechanism, where speaker-dependent prosody features are adopted as the attention query, which result from a prosody encoder with target speaker embedding and normalized pitch and energy of source speech as input. Finally the decoder consumes the integrated features and the speaker-dependent prosody feature to generate the converted speech. Experiments demonstrate that Expressive-VC is superior to several state-of-the-art systems, achieving both high expressiveness captured from the source speech and high speaker similarity with the target speaker; meanwhile intelligibility is well maintained

Learn2Sing 2.0: Diffusion and Mutual Information-Based Target Speaker SVS by Learning from Singing Teacher

Building a high-quality singing corpus for a person who is not good at singing is non-trivial, thus making it challenging to create a singing voice synthesizer for this person. Learn2Sing is dedicated to synthesizing the singing voice of a speaker without his or her singing data by learning from data recorded by others, i.e., the singing teacher. Inspired by the fact that pitch is the key style factor to distinguish singing from speaking voice, the proposed Learn2Sing 2.0 first generates the preliminary acoustic feature with averaged pitch value in the phone level, which allows the training of this process for different styles, i.e., speaking or singing, share same conditions except for the speaker information. Then, conditioned on the specific style, a diffusion decoder, which is accelerated by a fast sampling algorithm during the inference stage, is adopted to gradually restore the final acoustic feature. During the training, to avoid the information confusion of the speaker embedding and the style embedding, mutual information is employed to restrain the learning of speaker embedding and style embedding. Experiments show that the proposed approach is capable of synthesizing high-quality singing voice for the target speaker without singing data with 10 decoding steps.Comment: Submitted to INTERSPEECH 202

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field