(1E)-6-Meth­oxy-3,4-dihydro­naphthalen-1(2H)-one oxime

In the crystal structure of the title compound, C11H13NO2, the mol­ecules are paired into centrosymmetric dimers via inter­molecular O—H⋯N hydrogen bonds

Anomalous Transport in Sketched Nanostructures at the LaAlO3/SrTiO3 Interface

The oxide heterostructure LaAlO3/SrTiO3 supports a two-dimensional electron liquid with a variety of competing phases including magnetism, superconductivity and weak antilocalization due to Rashba spin-orbit coupling. Further confinement of this 2D electron liquid to the quasi-one-dimensional regime can provide insight into the underlying physics of this system and reveal new behavior. Here we describe magnetotransport experiments on narrow LaAlO3/SrTiO3 structures created by a conductive atomic force microscope lithography technique. Four-terminal local transport measurements on ~10-nm-wide Hall bar structures yield longitudinal resistances that are comparable to the resistance quantum h/e2 and independent of the channel length. Large nonlocal resistances (as large as 10^4 ohms) are observed in some but not all structures with separations between current and voltage that are large compared to the 2D mean-free path. The nonlocal transport is strongly suppressed by the onset of superconductivity below ~200 mK. The origin of these anomalous transport signatures is not understood, but may arise from coherent transport defined by strong spin-orbit coupling and/or magnetic interactions

A Robust and Powerful Set-Valued Approach to Rare Variant Association Analyses of Secondary Traits in Case-Control Sequencing Studies

In many case-control designs of genome-wide association (GWAS) or next generation sequencing (NGS) studies, extensive data on secondary traits that may correlate and share the common genetic variants with the primary disease are available. Investigating these secondary traits can provide critical insights into the disease etiology or pathology, and enhance the GWAS or NGS results. Methods based on logistic regression (LG) were developed for this purpose. However, for the identification of rare variants (RVs), certain inadequacies in the LG models and algorithmic instability can cause severely inflated type I error, and significant loss of power, when the two traits are correlated and the RV is associated with the disease, especially at stringent significance levels. To address this issue, we propose a novel set-valued (SV) method that models a binary trait by dichotomization of an underlying continuous variable, and incorporate this into the genetic association model as a critical component. Extensive simulations and an analysis of seven secondary traits in a GWAS of benign ethnic neutropenia show that the SV method consistently controls type I error well at stringent significance levels, has larger power than the LG-based methods, and is robust in performance to effect pattern of the genetic variant (risk or protective), rare or common variants, rare or common diseases, and trait distributions. Because of the SV method’s striking and profound advantage, we strongly recommend the SV method be employed instead of the LG-based methods for secondary traits analyses in case-control sequencing studies

"Water-cycle" mechanism for writing and erasing nanostructures at the LaAlO3/SrTiO3 interface

Nanoscale control of the metal-insulator transition in LaAlO3/ SrTiO3 heterostructures can be achieved using local voltages applied by a conductive atomic-force microscope probe. One proposed mechanism for the writing and erasing process involves an adsorbed H2O layer at the top LaAlO3 surface. In this picture, water molecules dissociates into OH- and H+ which are then selectively removed by a biased AFM probe. To test this mechanism, writing and erasing experiments are performed in a vacuum AFM using various gas mixtures. Writing ability is suppressed in those environments where H2O is not present. The stability of written nanostructures is found to be strongly associated with the ambient environment. The self-erasure process in air can be strongly suppressed by creating a modest vacuum or replacing the humid air with dry inert gas. These experiments provide strong constraints for theories of both the writing process as well as the origin of interfacial conductance.Comment: 11 pages, 3 figure

Experimental verification of the steering ellipsoid zoo via two-qubit states

Quantum steering ellipsoid visualizes the set of all qubit states that can be steered by measuring on another correlated qubit in the Bloch picture. Together with local reduced states, it provides a faithful geometric characterization of the underlying two-qubit state so that almost all nonclassical state features can be reflected in its geometric properties. Consequently, the various types of quantum ellipsoids with different geometric properties form an ellipsoid zoo, which, in this work, is experimentally verified via measurements on many polarization-path photonic states. By generating two-qubit states with high fidelity, the corresponding ellipsoids are constructed to certify the presence of entanglement, one-way Einstein-Podolsky-Rosen steering, discord, and steering incompleteness. It is also experimentally verified that the steering ellipsoid can be reconstructed from using the twelve vertices of the icosahedron as measurement directions. Our results aid progress in applying the quantum steering ellipsoid to reveal nonclassical features of the multi-qubit system

Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice

Erchen decoction (ECD) is a traditional Chinese medicine prescription, which is used in the treatment of obesity, hyperlipidemia, fatty liver, diabetes, hypertension, and other diseases caused by retention of phlegm dampness. In this study we investigated the potential mechanism of ECD, using metabolism-disabled mice induced by high-fat diet. Body weight and abdominal circumference were detected. OGTT was measured by means of collecting blood samples from the tail vein. Blood lipid levels and insulin were measured using biochemical assay kit. Real-time PCR was used to measure the CDKAL1 gene expression and western blot was used to measure the protein expression. Through the research, it was found that ECD showed markedly lower body weight and abdominal circumference than those in the HFD group. Consistently, we observed that ECD significantly improved glucose tolerance, promoted the secretion of insulin and decreased the level of TG, TC level. Meanwhile, we observed significantly increased CDKAL1 mRNA and protein level in the ECD group. Therefore, we speculate that the potential molecular mechanism of ECD is to promote the CDKAL1 expression, ameliorate islet cell function, and raise insulin levels to regulate the metabolic disorder

EX-PRESS glaucoma drainage device combined with phacoemulsification in treatment of POAG with cataract

AIM: To observe the clinical effect of combined cataract and primary open-angle glaucoma underwent phacoemulsification and glaucoma drainage device implantation.METHODS: We selected in our hospital from January 2014 to February 2016, 42 cases(42 eyes)with primary open-angle glaucoma with cataract. According to random number table method, all of the patients were randomly divided into two groups, control group and study group. In control group, 21 patients(21 eyes)underwent trabecular resection combined phacoemulsification; in study group patients, 21 patients(21 eyes), underwent EX-PRESS glaucoma drainage device combined phacoemulsification. Compared parameters included postoperative complications and filtering bleb, visual acuity, intraocular pressure(IOP)and other clinical indicators between two groups. RESULTS: Preoperative IOP of two groups was no significantly different(P>0.05). Postoperative IOP at each time point was significantly lower than before treatment(PPP>0.05). At 12wk after treatment, surgical success rate of study group was 95%, significantly higher than that of control group 71%(PP>0.05). At 12wk after treatment, 21 patients in study group were shown as functional filtering bleb, while in the control group 18 cases was functional filtering bleb.CONCLUSION:Using EX-PRESS glaucoma drainage device combined with phacoemulsification in treating cataract with primary open-angle glaucoma is reliable, the curative effect is better than that by trabeculectomy combined with phacoemulsification treatment