4 research outputs found
Design, Synthesis, Characterization and Biological Activities of few Heterocyclic Compounds
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Fuller’s earth catalyzed rapid synthesis of bis (indolyl) methanes under solvent free condition
A rapid and highly efficient synthesis of various bis(indolyl)methanes with high yield by the reaction of indoles 1a-c and arylaldehydes 2a'-m' in presence of fuller’s earth is demonstrated. This simple and versatile protocol is found to be an efficient catalyst for the electrophilic addition reaction of indole and works well under solvent free condition as well as in aqueous medium. The structure of newly synthesized compound 3m has been confirmed by single crystal X-ray crystallography
<span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Fuller’s earth catalyzed rapid synthesis of bis(indolyl)methanes under solvent free condition</span>
1032-1038<span style="font-size:12.0pt;font-family:
" times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">A rapid and highly
efficient synthesis of various bis(indolyl)methanes with high yield by the reaction
of indoles 1a-c and arylaldehydes 2a'-m' in presence of fuller’s earth is
demonstrated. This simple and versatile protocol is found to
be an efficient catalyst for the electrophilic addition reaction of indole and
works well under solvent free condition as well as in aqueous medium. The
structure of newly synthesized compound 3m
has been confirmed by single crystal X-ray crystallography.</span