Floral diversity and ecology in Kalyani area of Nadia district, West Bengal, India

An assessment of plant diversity was carried out to record different species of flowering plants (Angiosperms) in Kalyani township of Nadia district, West Bengal, India during January, 2014. All together 6 quadrats were laid down, and 30 flowering plant species belonging to 15 families were documented. Voucher specimens were preserved and digitized in departmental phyto-informatics center. Frequency and density varied greatly among the taxa, while many species were not evenly abundant in the study area. Out of total species, 11 species can be used as economic and medicinal plants. There are also some alien invasive species of diverse origin

Binding of the putative anticancer agent chelerythrine to double stranded poly(A): Calorimetry and spectral characterization studies

The benzophenanthridine plant alkaloid chelerythrine was recently reported to bind to single stranded polyriboadenylic acid [ss poly(A)] through an entropy driven process with remarkably high binding affinity (�107 M�1) (Basu and Suresh Kumar, 2015). Considering the anticancer effects of chelerythrine along with its potential to be developed as an RNA targeted drug due to its high affinity to ss poly(A), here we studied the binding of chelerythrine to double stranded (ds) poly(A). The binding was characterized thermodynamically by enthalpy and entropy changes, and enthalpy-entropy compensation behaviour. The binding thermally stabilized the structure. The binding led to hypochromic and bathochromic effects in the visible absorption spectrum of chelerythrine and enhanced its fluorescence intensity. An intercalative binding mode was deduced from fluorescence quenching, anisotropy, and viscometric studies. The binding of chelerythrine to the ds poly(A) was significantly weaker than its binding to ss poly(A). The results may lead to designing RNA targeted therapeutics and a useful agent in gene regulation in eukaryotic cells