In-Vitro Anti-oxidant And Antimicrobial Study of Ficus Hispida

Ficus hispida L. belongs to the Moraceae family and is used by the maaiba trible (indigenous medicine - man of Manipur, India) as an indigenous traditional medicine. Present study deals with the successive extraction of the aerial parts of Ficus hispida and in-vitro screening of anti-oxidant and anti-microbial activity. The phytochemical screening of the methanol extract of Ficus hispida shows the presence of secondary metabolite groups like alkaloid, phenolic compounds, flavonoid, glycosides, protein etc. Phenolic compounds are commonly found in both edible and nonedible plants and are responsible for various medicinal activities of plants, so our study is based on determining antioxidant activity and anti-microbial activity. Beside these, we also measured the total flavonoid and total phenolic content of the respective sample to understand the effect of polyphenolic compound on different pathophysiological state associated with high free radical production. The in-vitro investigation proves the efficiency of this plant in various diseases states

Facile fabrication of fluorine free zirconium zinc stearate based superhydrophobic and superoleophilic coating on cotton fabric with superior antibacterial property

A simple solution technique has been adopted to fabricate in situ generated zirconium zinc stearate based superhydrophobic and superoleophilic fluorine-free coating on cotton fabric with superior antibacterial and excellent photocatalytic properties. The materials properties of the specimen such as crystallinity/crystal phase, chemical bonding, surface morphology, and surface roughness have been characterized systematically. The coated cotton derived from an optimized precursor composition shows the retention of superhydrophobicity with static water contact angle \~163 degrees after several cycles of machine laundering and mechanical abrasion. It is seen that zirconium species may have caused an enhancement in laundering durability and mechanical robustness while hierarchical morphology of zinc stearate is responsible for acquiring superior antibacterial property along with self cleaning ability of the coating to make the coated fabric promising for real life application such as military uniform, biomedical clothing/devices. In addition, the coated cotton is found to be suitable for separation of oil from oil-water mixtures with high efficiency (\~99%) even after 10 cycles of repeated use. Thus, the material can be used for separation of oil from oil-contaminated industrial wastewater/marine water. Moreover, AgBr modified superhydrophobic cotton fabric shows excellent photocatalytic activity towards degradation of organic dye. This facile process can be up-scaled for commercial u

Quality Related Safety Evaluation of a South African Traditional Formulation (PHELA^®) as Novel Anti-Biofilm Candidate

A South African traditional formulation, PHELA®, is consumed by the traditional people for severe chest problems with coughing, diarrhea, oral ulcers etc. The present study focused on establishing the anti-infective properties of a safe and standardized poly-herbal formulation through a series of criteria and specifications

Formulation Development, Optimization, and Characterization of Cilnidipine-Loaded Self-microemulsifying Drug Delivery System

Cilnidipine, a 2, 4-dihydropyridine antihypertensive, is poorly bioavailable and belongs to Biopharmaceutical Classification System Class II. The present study was carried out to develop and evaluate a cilnidipine-loaded self-microemulsifying drug delivery system (SMEDDS) using food grade oil for enhanced pharmacokinetic parameters. The SMEDDS was prepared by low-energy method. A pseudo-ternary phase diagram was developed using triacetin, Tween 20, and Transcutol HP as oil, surfactants, and cosurfactants, respectively. The statistically optimized formulation was obtained and was evaluated for relevant in vitro characterizations. Globule size, zeta potential, and polydispersity index (PDI) of the optimized formulation were found to be 9.045 nm, −2.32 mv and 0.203, respectively, indicating stable and uniformly distributed microemulsion nature of the formulation. Developed SMEDDS of viscosity 31 cps was found to be clear in 500 times dilution in water and phosphate buffer pH 1.2. Selection of the optimized SMEDDS was followed by various formulation characteristics, including goat intestinal membrane permeability. The in vitro dissolution study of optimized SMEDDS exhibited much better result as compared to the marketed tablet of cilnidipine

Vaccine Formulation Strategies and Challenges Involved in RNA Delivery for Modulating Biomarkers of Cardiovascular Diseases: A Race from Laboratory to Market

It has been demonstrated that noncoding RNAs have significant physiological and pathological roles. Modulation of noncoding RNAs may offer therapeutic approaches as per recent findings. Small RNAs, mostly long noncoding RNAs, siRNA, and microRNAs make up noncoding RNAs. Inhibiting or promoting protein breakdown by binding to 3’ untranslated regions of target mRNA, microRNAs post-transcriptionally control the pattern of gene expression. Contrarily, long non-coding RNAs perform a wider range of tasks, including serving as molecular scaffolding, decoys, and epigenetic regulators. This article provides instances of long noncoding RNAs and microRNAs that may be a biomarker of CVD (cardiovascular disease). In this paper we highlight various RNA-based vaccine formulation strategies designed to target these biomarkers—that are either currently in the research pipeline or are in the global pharmaceutical market—along with the physiological hurdles that need to be overcome

Vaccine Formulation Strategies and Challenges Involved in RNA Delivery for Modulating Biomarkers of Cardiovascular Diseases: A Race from Laboratory to Market

It has been demonstrated that noncoding RNAs have significant physiological and pathological roles. Modulation of noncoding RNAs may offer therapeutic approaches as per recent findings. Small RNAs, mostly long noncoding RNAs, siRNA, and microRNAs make up noncoding RNAs. Inhibiting or promoting protein breakdown by binding to 3’ untranslated regions of target mRNA, microRNAs post-transcriptionally control the pattern of gene expression. Contrarily, long non-coding RNAs perform a wider range of tasks, including serving as molecular scaffolding, decoys, and epigenetic regulators. This article provides instances of long noncoding RNAs and microRNAs that may be a biomarker of CVD (cardiovascular disease). In this paper we highlight various RNA-based vaccine formulation strategies designed to target these biomarkers—that are either currently in the research pipeline or are in the global pharmaceutical market—along with the physiological hurdles that need to be overcome

data file.docx

All the data on the basis of which different graphs have been drawn and represented as figures, have been mentioned in the data file or dataset </p