Histopathological spectrum of gastrointestinal lesions - an experience in a tertiary care centre in South India

Background: Gastrointestinal biopsies are the major group specimens received in the surgical pathology department.  This includes endoscopic biopsies from gastric and duodenal mucosa, appendicectomies, cholecystectomies and colonoscopic biopsies.  This study aims at identifying the different histopathological lesions in these specimens. Methods: The study was a retrospective study conducted in the Department of Pathology, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India from January 2013-January 2014.  194 gastrointestinal biopsies were included in this study.  These biopsies were fixed in 10% buffered formalin and routinely processed and paraffin embedded sections were taken and stained with Hematoxylin and Eosin.  The slides were interpreted and the statistical analysis of the data obtained was done.Results: The most common specimen received was appendix (39%).  The next common specimen was endoscopic gastric mucosal biopsies (20%).  We had 25 cholecystectomy specimens (13%) and 17 fistulous tract excisions (9%).  The other specimens studied are 20 colonoscopic biopsies (10%), six esophageal mucosal biopsies (4%), four vocal cord biopsies (2%), two liver biopsies (1%), two tonsillar biopsies (1%), and one biopsy from pharynx (1%).Conclusions: Histopathological analysis of gastrointestinal lesions aids the clinicians for follow up and specific treatment.  This study gives an overview of the different histopathological specimens received in the surgical pathology department and analyses the varied histomorphological diagnosis given for these specimens.

CELL CYCLE REGULATORY MECHANISMS IN SKELETAL MUSCLE CELLS

Ph.DDOCTOR OF PHILOSOPH

G9a, a multipotent regulator of gene expression

10.4161/epi.23331Epigenetics8116-2

Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation

10.1073/pnas.1111628109Proceedings of the National Academy of Sciences1093841-84

Red edge excitation effect in intact eye lens

Shift in the wavelength of emission upon shift in the excitation wavelength towards the red edge of the absorption band is termed Red Edge Excitation Shift (REES). This effect is observed only in a situation where the fluorophore mobility with respect to the surrounding matrix is considerably reduced. We have observed such red edge excitation effect in the intact eye lens. The REES observed for a normal lens is different from that seen in a photodamaged lens and hence appears to be a potential tool to monitor the changes in the state of the lens. Photodamage experiments with tryptophan in polyethylene glycol (PEG) and intact eye lens indicate that the red edge photon can also cause photodamage

Oxidation of Carbon Monoxide on Doped Nickel Oxide Catalysts

350-35