Remote preconditioning by aortic constriction: affords cardioprotection as classical or other remote ischemic preconditioning? Role of iNOS

Dose remote preconditioning by aortic constriction (RPAC) affords cardioprotection similar to classical or other remote ischemic preconditioning stimulus? Moreover study was also designed to investigate role of inducible nitric oxide synthase in remote preconditioning by aortic constriction. There are sufficient evidences that "ischemic preconditioning" has surgical applications and afford clinically relevant cardioprotection. Transient occlusion of circumflex artery, renal artery, limb artery or mesenteric artery preconditions the myocardium against ischemia reperfusion injury in case of ischemic heart disease leading to myocardial infraction. Here abdominal aorta was selected to produce RPAC. Four episodes of Ischemia-reperfusion of 5 min each to abdominal aorta produced RPAC by assessment of infract size, LDH and CK. These studies suggest RPAC produced acute (FWOP) and delayed (SWOP) cardioprotective effect. RPAC demonstrated a significant decrease in Ischemia-reperfusion induced release of LDH, CK and extent of myocardial infract size. L-NAME (10 mg/Kg i.v.), Aminoguanidine (150 mg/Kg s.c.), Aminoguanidine (300 mg/Kg s.c.), S-methyl isothiourea (3 mg/Kg i.v.), 1400W (1 mg/Kg i.v.) administered 10 min. before global ischemia reperfusion produced no marked effect. Aminoguanidine (150 mg/Kg s.c.), Aminoguanidine (300 mg/Kg s.c.), S-methyl isothiourea (3 mg/Kg i.v.), 1400W (1 mg/Kg i.v.) pretreatment after RPAC produced no significant effect on acute RPAC induced decrease in LDH, CK and infract size, whereas L-NAME (10 mg/Kg i.v.) increased RPAC induced decrease in LDH, CK and infract size. Most interesting observation is in delayed RPAC, where all NOS inhibitors pretreatment attenuate RPAC induced decrease in LDH, CK and infract size. In conclusions, "Remote preconditioning by aortic constriction" (RPAC) affords cardioprotection similar to classical or other remote ischemic preconditioning stimulus. Moreover, late or delayed phase of RPAC has been mediated by inducible nitric oxide synthase (iNOS) whereas it has not involved in acute RPAC

Short clinical crowns (SCC) ' treatment considerations and techniques

When the clinical crowns of teeth are dimensionally inadequate, esthetically and biologically acceptable restoration of these dental units is difficult. Often an acceptable restoration cannot be accomplished without first surgically increasing the length of the existing clinical crowns; therefore, successful management requires an understanding of both the dental and periodontal parameters of treatment. The complications presented by teeth with short clinical crowns demand a comprehensive treatment plan and proper sequencing of therapy to ensure a satisfactory result. Visualization of the desired result is a prerequisite of successful therapy. This review examines the periodontal and restorative factors related to restoring teeth with short clinical crowns. Modes of therapy are usually combined to meet the biologic, restorative, and esthetic requirements imposed by short clinical crowns. In this study various methods for treating short clinical crowns are reviewed, the role that restoration margin location play in the maintenance of periodontal and dental symbiosis and the effects of violation of the supracrestal gingivae by improper full-coverage restorations has also been discussed

History of materials used for recording static and dynamic occlusal contact marks: a literature review

In the discipline of prosthetic dentistry it is important not only to examine the occlusion, but to be able to record, store, and transfer the information. Over the years many occlusion testing materials have been used. It has been suggested the clinical recording and transfer of information using waxes and other occlusion recording materials have disadvantages relating to inaccuracy and problems of manipulation. Therefore, there has been introduction of many new systems for recording occlusion contacts to overcome such problems. The correct physiological recovery of occlusion posses as much a challenge as ever for every dentist and technician. Even the smallest high spots measuring just a few microns can cause dysfunctions like temporo-mandibular pain. Occlusal proportions are being constantly changed with every procedure. Therefore, an understanding of the synergy of the teeth in static and dynamic occlusion forms the basis of good dentistry. The purpose of this review article is to give and overview of the various materials and methods that have been used to record occlusal contact marks

ROLE OF EFFECTIVE QUALITY RISK MANAGEMENT IN DRUG SAFETY PROJECT

Identifying risk is one of the key topics of discussion in project planning and update meetings. Project managers have to identify and manage different risks at various levels of projects. These risks must be managed and eradicated in the effective and structured manner to perform effective quality risk management and thus leading to adequate project management. The research investigates the potential root cause of the quality risk management issues using tools such as the fishbone diagram (Ishikawa), 5-Whys, FTA etc. which could remedy this situation. An effectiveness check measure can also be implemented after applying corrective/preventive actions to ensure that quality is met at each step of the process. Over 90 articles were searched using keywords risk minimization plan, benefit-risk assessment, drug safety, and pharmacovigilance. The search was further narrowed to 16 articles which had information based on human studies and drug safety. Non-human studies and single case assessments were excluded from the research. The quality data of 20 large pharmaceutical companies were surveyed extensively and it was suggested that only limited number of projects used very rare risk management practices and most of the projects do not use all the current tools of risk management. The most extensively used method of quality risk management included failure mode and effects analysis. This technique was mostly utilized in assessing change control and failed investigations. The data of this analysis suggested that risk management strategies are not used extensively. This research recommends the practice of tools used for quality risk management such as fish-bone diagram (Ishikawa) and FTA at early stages of drug development. Effectiveness check measure is also suggested to ensure that quality is met at each step of the drug safety. There may be other risk-benefit assessment methods which are not identified by this research and further research is warranted to guarantee the success of these measures

Nitrofurantoin susceptibility profile versus other antibiotics tested in uropathogens- a retrospective study from India

Introduction. Urinary Tract Infection (UTI) is one of the most common bacterial infections encountered by clinicians worldwide. The emergence of multidrug-resistant uropathogens necessitates a review of their susceptibility profiles. This study aims to assess the susceptibility trends of uropathogens to a panel of drugs, with special emphasis on Nitrofurantoin (NFT). Methods. A retrospective analysis was conducted on 2,099 mid-stream clean catch urine samples processed by standard microbiological methods. Clinical and Laboratory Standards Institute (CLSI) guidelines (2019) were followed. Statistical analysis was performed. Results. Out of all samples, 212 were culture positive. Escherichia coli (34.9%) and Enterococcus spp. (15.1%) were the most common Gram-negative and Gram-positive organisms, respectively. Gram-negative isolates were most susceptible to Colistin (97.38%), followed by NFT (69.35%). Gram-positive uropathogens were most sensitive to Linezolid (100%), followed by Vancomycin and NFT, each with 92.45% susceptibility. Conclusion. The increase in antibiotic resistance among various uropathogens underscores the need for surveillance data to inform the appropriate selection of antibiotics. Our study highlights that, among the panel of antibiotics tested, NFT appears to be a viable alternative for treating multidrug-resistant uropathogens

Navigating career success: How career commitment shapes self-efficacy and career resilience for subjective career success

Purpose– This study examines the subjective dimension of career success in the dynamic global tourism industry, specifically the relationship between Career Commitment (CC) and Subjective Career Success (SCS). It uses a serial mediation framework with self-efficacy (SE) and career resilience (CR) as mediators and focuses on tourism professionals. Research methodology – We developed a theoretical serial mediation model to investigate this relationship. We conducted regression analysis using SPSS version 25 and AMOS (the Process Macro model 6) to test our proposed hypotheses. A total of 357 employees from various tourism-related organizations participated in this research. Findings – Employees who invested in their careers reported higher satisfaction with SCS in their working lives. Independently and consecutively, SE and CR influenced the association between CC and SCS. Research implications and Originality – The implications of this research extend to individuals and tourism organizations. For individuals, it provides a deeper understanding of how CC, SE and CR interact to manage the complexities of the tourism industry and promote professional success. For organizations, it highlights the importance of promoting CC through effective career development initiatives that can lead to a competent and motivated workforce, which ultimately increases employee engagement and retention

A study on Social Maturity, School Adjustment and Academic achievement among residential school girls

The present study is aimed at studying the relationship between Social Maturity, School Adjustment and levels of Academic achievement among residential school girl students. The study was conducted on a sample of 347 girls from class ix –xii at an all girls residential school of North India. Dr. Nalini Rao’s Social Maturity Scale (RSMS) was used to measure social maturity, Sinha & Singh’s Adjustment Inventory for School Students (AISS) was used to measure school adjustment and   aggregate score of the students in the year end final examination was taken to assess level of their academic achievement. The results indicated a significant relationship between social maturity and school adjustment. Also, significant difference existed between the school adjustments of the three groups i.e. low, high and average levels of academic achievement. Key words: Residential school, Social maturity, School Adjustment, Academic achievement

PSO Algorithm Based Resource Allocation for OFDM Cognitive Radio

With the development of remote correspondences, the issue of data transmission lack has turned out to be more conspicuous. Then again, to sense the presence of authorized clients, range detecting procedures are utilized. Vitality recognition, Matched channel identification and Cyclo-stationary component location are the three ordinary techniques utilized for range detecting. However there are a few downsides of these strategies. The execution of vitality indicator is helpless to instability in noise power. Coordinated channel range detecting strategies require a devoted collector for each essential client. Cyclo-stationary element Detection requires parcel of calculation exertion and long perception time. This proposition talks about the routine vitality location strategy and proposed enhanced vitality identification technique utilizing cubing operation. Additionally, cyclic prefix based range detecting is talked about in this theory. Scientific Description of vitality location and cyclic prefix based range detecting strategies is likewise delineated for fading channels

Elective versus emergency caesarean section: differences in maternal outcome

Background: Caesarean section is a life-saving surgical procedure when certain complications arise during pregnancy or labour. The use of CS worldwide has increased worldwide unprecedented levels although the gap between higher- and lower-resource settings remains. The present study evaluates the difference in maternal outcome in elective versus emergency caesarean sections in our institute.Methods: The study included first 65 cases of emergency caesarean section (group A) and during the study period, first 65 elective caesarean section (group B) if they fulfilled the inclusion criteria. Various intra operative and postoperative events were recorded which included intra operative complications, postpartum haemorrhage and transfusion indices.Results: The most common indication of caesarean section in group A was fetal distress (27.7%). In group B most caesarean sections were classified under 5 followed by class 6, the most common indication being previous caesarean section (27.6%). It was observed that pre-operative mean haemoglobin in group A was 10.6 g/dl and in group B was 11.2g/dl. A drop of 1.36 g/dl in group A and 1.10 g/dl in group B was observed in the post-op period. Cross match / transfusion ratio 1.5 in group A and  2 in group B, transfusion probability ratio was 60 % in group A and  66.7%  in group B and transfusion index was 1 in group A and  group B. There was significantly higher contraception acceptance in group B compared to group A.Conclusions: Elective caesarean section has more favourable maternal outcome as compared to emergency caesarean section as the former is done under controlled and planned circumstances.  However, there should be stringent audit to scrutinise indication of caesarean section, outcome of caesarean and blood transfusion practices