9 research outputs found
Evaluate the prevalence of risk factors among patients of myocardial infarction in our population: review of one hundred forty-seven cases
Background: CAD is disease of persons older than 45 years of age. In India, CAD in males, it manifests earlier than west European and North American males. This study is designed to study prevalence of risk factors (and angiographic profiles) amongst patients of Myocardial infarction in our population. Methods: Total of 147 consecutive patients of AMI were studied for risk factors.Results: Out of 147 patients, 116 (79%) were males and 31 (21%) were females. 11 (9.5%) of males and 01 (3.2%) of females were below 40 years of age. Whereas 34 (29.3%) of males and 06 (19.4%) females were of below 50 years of age. Median age for males was 54 years while that for females was 63 years. Smoking remains most prevalent amongst males while high LDL and HT remain most prevalent amongst young and overall females respectively. 108 patients had STEMI while 39 had NSTEMI.Conclusions: AMI occurs much frequently in males. Median age for males is almost one decade earlier than West European males and nearly 5 years earlier than North American males. Smoking is most common and hypertension second most common risk factors amongst males. In females median age for AMI is almost one decade later than Indian males. It is similar to North American females while nearly 5 years earlier than Western Europe females. HT and DM remain first and second common risk factors amongst females.
Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain
Background: The goal of treatment in arteriovenous malformation (AVM)
is total obliteration of the AVM, restoration of normal cerebral
function, and preservation of life and neurological function. Aim: To
analyze the results of X-knife and surgery for AVM of the brain. The
endpoints for success or failure were as follows: success was defined
as angiographic obliteration and failure as residual lesion, requiring
retreatment, or death due to hemorrhage from the AVM. Materials and
Methods: From May 2002 to May 2007, 54 patients were enrolled for this
study. Grade I AVM was seen in 9%, grade II in 43%, grade III in 26%,
grade IV in 9%, and grade V in 13%. Thirty-eight patients were treated
by microsurgical resection out of which Grade I was seen in 5 patients,
Grade II was seen in 17 patients, Grade III was seen in 9 patients and
Grade V was seen in 7 patients. Rest of the sixteen patients were
treated by linear accelerator radiosurgery out of which Grade II was
seen in 6 patients, Grade III was seen in 5 patients and Grade IV was
seen in 5 patients. The follow up was in range of 3-63 months. In
follow up, digital subtraction angiography/ magnetic resonance
angiography (DSA/MRA) was performed 3 months after surgery and 1 year
and 2 years after stereotactic radiosurgery (SRS). Results: Among the
patients treated with X-knife, 12/16 (75%) had proven angiographic
obliteration. Complications were seen in 4/16 (25%) patients. Among the
patients treated with microsurgical resection, 23/38 (61%) had proven
angiographic obliteration. Complications (both intraoperative and
postoperative) were seen in 19/38 (50%) patients. Conclusions:
Sixty-one percent of patients were candidates for surgical resection.
X-knife is a good modality of treatment for a low-grade AVM situated in
eloquent areas of the brain and also for high-grade AVMs, when the
surgical risk and morbidity is high
Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain
<b>Background:</b> The goal of treatment in arteriovenous malformation (AVM) is total obliteration of the AVM, restoration of normal cerebral function, and preservation of life and neurological function. <b>Aim:</b> To analyze the results of X-knife and surgery for AVM of the brain. The endpoints for success or failure were as follows: success was defined as angiographic obliteration and failure as residual lesion, requiring retreatment, or death due to hemorrhage from the AVM. <b>Materials and Methods:</b> From May 2002 to May 2007, 54 patients were enrolled for this study. Grade I AVM was seen in 9%, grade II in 43%, grade III in 26%, grade IV in 9%, and grade V in 13%. Thirty-eight patients were treated by microsurgical resection out of which Grade I was seen in 5 patients, Grade II was seen in 17 patients, Grade III was seen in 9 patients and Grade V was seen in 7 patients. Rest of the sixteen patients were treated by linear accelerator radiosurgery out of which Grade II was seen in 6 patients, Grade III was seen in 5 patients and Grade IV was seen in 5 patients. The follow up was in range of 3-63 months. In follow up, digital subtraction angiography/ magnetic resonance angiography (DSA/MRA) was performed 3 months after surgery and 1 year and 2 years after stereotactic radiosurgery (SRS). <b>Results: </b> Among the patients treated with X-knife, 12/16 (75%) had proven angiographic obliteration. Complications were seen in 4/16 (25%) patients. Among the patients treated with microsurgical resection, 23/38 (61%) had proven angiographic obliteration. Complications (both intraoperative and postoperative) were seen in 19/38 (50%) patients. <b>Conclusions:</b> Sixty-one percent of patients were candidates for surgical resection. X-knife is a good modality of treatment for a low-grade AVM situated in eloquent areas of the brain and also for high-grade AVMs, when the surgical risk and morbidity is high
Randomized comparative trial of efficacy of paracetamol, ibuprofen and paracetamol-ibuprofen combination for treatment of febrile children
Objective: Paracetamol and ibuprofen are widely used for fever in children as monotherapy and as combined therapy. None of the treatments is proven clearly superior to others. Hence, the study was planned to compare the efficacy of paracetamol, ibuprofen and paracetamol-ibuprofen combination for treatment of febrile children. Materials and Methods: This was an investigator blind, randomized, comparative, parallel clinical trial conducted in 99 febrile children, 6 months to 12 years of age, allocated to three groups. First group received paracetamol 15 mg/kg, second group received ibuprofen 10 mg/kg and third group received both paracetamol and ibuprofen, all as a single dose by the oral route. Patients were followed-up at intervals of 1, 2, 3 and 4 h post dose by tympanic thermometry. Results: Mean tympanic temperature after 4 h of drug administration was significantly lower in the combination group compared with paracetamol group (P < 0.05); however, the difference was not clinically significant (<1C). The rate of fall of temperature was highest in the combination group. Number of afebrile children any time post dose until 4 h was highest in the combination group. Difference between combination and paracetamol was significant for the 1 st h (P = 0.04). Highest fall of temperature was noted in the 1 st h of drug administration in all the groups. No serious adverse events were observed in any of the groups. Conclusion: Paracetamol and ibuprofen combination caused quicker temperature reduction than either paracetamol or ibuprofen alone. If quicker reduction of body temperature is the desired goal of therapy, the use of combination of paracetamol + ibuprofen may be advocated
Technical Report - Retrospective analysis of role of interstitial brachytherapy using template (MUPIT) in locally advanced gynecological malignancies
Aim : The aim of this retrospective study was to assess treatment
outcomes for patients with locally advanced gynecological malignancies
being treated with interstitial brachytherapy using Martinez universal
perineal interstitial template (MUPIT) and to study the acute and late
sequelae and survival after treatment by this technique. Materials and
Methods : Ninety seven patients untreated with histopathological
confirmation of carcinoma of cervix (37) vault (40) and vagina (20)
were treated by combination of external beam RT (EBRT) using
megavoltage irradiation to pelvis to dose of 4000-5000 cGy followed by
interstitial brachytherapy using MUPIT between September 2001 to March
2005. Median age was 46 years. Only those patients who were found
unsuitable for conventional brachytherapy or in whom intracavitatory
radiotherapy was found to be unlikely to encompass a proper dose
distribution were treated by interstitial template brachytherapy using
MUPIT application and were enrolled in this study. The dose of MUPIT
was 1600-2400 cGy in 4-6# with 400 cGy /# and two fractions a day with
minimum gap of six hours in between two fractions on micro-HDR.
Criteria for inclusion of patients were as follows: Hb minimum 10
gm/dl, performance status - 70% or more (Karnofsy scale),
histopathological confirmation FIGO stage IIB-IIIB (excluding frozen
pelvis). Results : Among the 97 patients studied, 12 patients lost to
follow-up and hence they were excluded from the study. Follow-up of
rest of the patients was then done up to September 2006. The duration
of follow-up was in the range of 20-60 months. Parameters studied were
local control rate, complication rate, mortality rate and number of
patients developing systemic metastasis. Local control was achieved in
56/85 (64.7%) and complication rate was 15/85 (17.6%). Local control
was better for nonbulky tumors compared bulky tumors irrespective of
stage of disease. Local control was better in patients with good
regression of disease after external beam radiotherapy. Time of gap
between EBRT and implant also had an impact on the outcome. Conclusion
: Interstitial template brachytherapy by MUPIT is a good alternative to
deliver high dose radiation in locally advanced gynecological
malignancies where conventional brachytherapy application is either not
feasible or likely to give optimal dose distribution. Loco regional
control obtained is definitely better than EBRT alone and within the
accepted range of complications
Technical Report - Retrospective analysis of role of interstitial brachytherapy using template (MUPIT) in locally advanced gynecological malignancies
Aim : The aim of this retrospective study was to assess treatment
outcomes for patients with locally advanced gynecological malignancies
being treated with interstitial brachytherapy using Martinez universal
perineal interstitial template (MUPIT) and to study the acute and late
sequelae and survival after treatment by this technique. Materials and
Methods : Ninety seven patients untreated with histopathological
confirmation of carcinoma of cervix (37) vault (40) and vagina (20)
were treated by combination of external beam RT (EBRT) using
megavoltage irradiation to pelvis to dose of 4000-5000 cGy followed by
interstitial brachytherapy using MUPIT between September 2001 to March
2005. Median age was 46 years. Only those patients who were found
unsuitable for conventional brachytherapy or in whom intracavitatory
radiotherapy was found to be unlikely to encompass a proper dose
distribution were treated by interstitial template brachytherapy using
MUPIT application and were enrolled in this study. The dose of MUPIT
was 1600-2400 cGy in 4-6# with 400 cGy /# and two fractions a day with
minimum gap of six hours in between two fractions on micro-HDR.
Criteria for inclusion of patients were as follows: Hb minimum 10
gm/dl, performance status - 70% or more (Karnofsy scale),
histopathological confirmation FIGO stage IIB-IIIB (excluding frozen
pelvis). Results : Among the 97 patients studied, 12 patients lost to
follow-up and hence they were excluded from the study. Follow-up of
rest of the patients was then done up to September 2006. The duration
of follow-up was in the range of 20-60 months. Parameters studied were
local control rate, complication rate, mortality rate and number of
patients developing systemic metastasis. Local control was achieved in
56/85 (64.7%) and complication rate was 15/85 (17.6%). Local control
was better for nonbulky tumors compared bulky tumors irrespective of
stage of disease. Local control was better in patients with good
regression of disease after external beam radiotherapy. Time of gap
between EBRT and implant also had an impact on the outcome. Conclusion
: Interstitial template brachytherapy by MUPIT is a good alternative to
deliver high dose radiation in locally advanced gynecological
malignancies where conventional brachytherapy application is either not
feasible or likely to give optimal dose distribution. Loco regional
control obtained is definitely better than EBRT alone and within the
accepted range of complications
Analysis of X-knife and surgery in treatment of arteriovenous malformation of brain
Background: The goal of treatment in arteriovenous malformation (AVM)
is total obliteration of the AVM, restoration of normal cerebral
function, and preservation of life and neurological function. Aim: To
analyze the results of X-knife and surgery for AVM of the brain. The
endpoints for success or failure were as follows: success was defined
as angiographic obliteration and failure as residual lesion, requiring
retreatment, or death due to hemorrhage from the AVM. Materials and
Methods: From May 2002 to May 2007, 54 patients were enrolled for this
study. Grade I AVM was seen in 9%, grade II in 43%, grade III in 26%,
grade IV in 9%, and grade V in 13%. Thirty-eight patients were treated
by microsurgical resection out of which Grade I was seen in 5 patients,
Grade II was seen in 17 patients, Grade III was seen in 9 patients and
Grade V was seen in 7 patients. Rest of the sixteen patients were
treated by linear accelerator radiosurgery out of which Grade II was
seen in 6 patients, Grade III was seen in 5 patients and Grade IV was
seen in 5 patients. The follow up was in range of 3-63 months. In
follow up, digital subtraction angiography/ magnetic resonance
angiography (DSA/MRA) was performed 3 months after surgery and 1 year
and 2 years after stereotactic radiosurgery (SRS). Results: Among the
patients treated with X-knife, 12/16 (75%) had proven angiographic
obliteration. Complications were seen in 4/16 (25%) patients. Among the
patients treated with microsurgical resection, 23/38 (61%) had proven
angiographic obliteration. Complications (both intraoperative and
postoperative) were seen in 19/38 (50%) patients. Conclusions:
Sixty-one percent of patients were candidates for surgical resection.
X-knife is a good modality of treatment for a low-grade AVM situated in
eloquent areas of the brain and also for high-grade AVMs, when the
surgical risk and morbidity is high