PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK

Abstract Background Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment. Methods All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals. Results A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death. Conclusion Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions. </jats:sec

Advancement in fiber reinforced polymer, metal alloys and multi-layered armour systems for ballistic applications – a review

The recent research and development performed for armour systems for material selection and analysis has helped discover new and significant material properties suited for ballistic applications. The realm of ballistic studies has employed advanced materials to provide the desired performance, considering the strict requirement of perfect material selection for armour systems. Energy absorption, ballistic limit, and depth of indentation are the most important parameters to be analyzed for an efficient armour system. The importance of utilizing appropriate materials for armour system is necessary, to achieve higher energy absorption, ballistic limit, and low blunt trauma (<44 mm), while simultaneously ensuring the armour has low weight. The aim of this review is to analyze the different armour systems such as fiber reinforced polymeric composites, metallic and multilayer armour systems (MAS) to understand their response on ballistic impact. Also, the importance of advanced fabrication techniques such as bio-inspired fabrication and additive manufacturing for armour applications has been addressed in detail. Moreover, this review critically analyzed the possible ways to enhance the ballistic performance of fiber reinforced polymeric composites, metallic materials, and MAS

State of the art review about bio-inspired design and applications: an aerospace perspective

The field of bio-inspired design has tremendously transitioned into newer automated methods, yet there are methods being discovered which can elucidate underlying principles in design, materials, and manufacturing. Bio-inspired design aims to translate knowledge from the natural world to the current trends in industry. The recent growth in additive manufacturing (AM)methods has fueled the tremendous growth of bio-inspired products. It has enabled the production of intricate and complicated features notably used in the aerospace industry. Numerous methodologies were adopted to analyse the process of bio-inspired material selection, manufacturing methods, design, and applications. In the current review, different approaches are implemented to utilize bio-inspired designs that have revolutionized the aerospace industry, focusing on AM methods

State of the Art Review about Bio-Inspired Design and Applications: An Aerospace Perspective

The field of bio-inspired design has tremendously transitioned into newer automated methods, yet there are methods being discovered which can elucidate underlying principles in design, materials, and manufacturing. Bio-inspired design aims to translate knowledge from the natural world to the current trends in industry. The recent growth in additive manufacturing (AM)methods has fueled the tremendous growth of bio-inspired products. It has enabled the production of intricate and complicated features notably used in the aerospace industry. Numerous methodologies were adopted to analyse the process of bio-inspired material selection, manufacturing methods, design, and applications. In the current review, different approaches are implemented to utilize bio-inspired designs that have revolutionized the aerospace industry, focusing on AM methods