Personality in Alam and Katralai Novel

Alaam and Katralai are two novels written by S. Tamilchelvi.  A person's personality is formed by the influence of experiences, environment, education, society, culture, etc. which can be acquired from the birth till death. So personality itself is subject to change. Sundarampal and Manimegala are the heroines of the novels. After heroine’s husband leaves, they becomes the one who carries the burden of the family and brings up the girl children in a good manner. The purpose of this article is to examine the nature and behavioral characteristics of these heroine's in a detailed way

Cultural Records on Shiva Parvati’s Marriage through Kandhapuranam

Culture is a reflection of society’s history. Culture cannot be narrowed down to specific boundaries. The literature of the people is very helpful to know the culture of the people. Thus, the Kandhapuranam composed by KachiyappaSivachariyar is a storehouse of Culture. Kachiyappar has told not only mythological stories but also the culture of the Tamils of his time. Kachiyappar describes the marriage of Shiva and Parvathi in great detail. KachiyappaSivachariyar explains the marriage rituals of the Andhanars in the marriage of Shiva and Parvathi. Based on his notes, this article examines the marriage ceremony of the Andhanars of medieval time

Human Dignities in Kulothungan Poems

Human life is great. Human birth is one of the rarest of births. Only human beings have a uniqueness that no other birth has. Only man speaks, writes, studies, works, struggles, and labors in poverty. Olavaiyar says that it is rare to be born monitarai. The sixth sense is the gifted man who acquires reason. That is why it can bring other planets under its dominion. Although many appreciate the glory of such qualities of man, not all fully realize his astonishing power. But the poet Kulothungan is greatly surprised. That is why the purpose of this article is to explore the way in which the poet has praised and praised man in his poems considering man as more than God

The Ashram Life Duties in Margandeya Padalam

This article discusses about the life duties of a human being through Margandeya padalam from Kandhapuranam. In the everyday life People sets goals to achieve or complete their duties and growing themselves day by day. They create their own daily plans and moving on to the next part of their lives. Our ancestors classified this life into Ashram parts and also emphasized to live in those ways. They also named it as the duties of a human being. The purpose of this article is to make people to know about these life duties and make them to follow it in their lives

Spectrum and Local Metric Dimension of Andr\'asfai Graphs

The Andr\'asfai graph $And(k)$ for $k\geq 1$ is a circulant and triangle-free graph on 3k-1 vertices. In this paper, we have determined the least eigenvalue, second largest eigenvalue, and the number of distinct eigenvalues of the adjacency spectrum of $And(k)$. Also, we have found out the local metric dimension of $And(k)$

CUSTOM DESIGN PERSPECTIVE IN THE PROCESS PARAMETER OPTIMIZATION OF NANO LIPID CARRIERS

Objective: Nanostructured lipid carrier is an emerging lipid-derived delivery system that is rapidly gaining popularity due to the simplicity of the manufacturing technique. The primary task in formulating nanoparticles is to optimize the parameters that are involved in the process. The rationale behind this study is to optimize the process parameters for the preparation of nanostructured lipid carriers.  Methods: The optimization of selected techniques hot homogenization with ultra-sonication and melt dispersion technique, was carried out via statistical analysis software JMP version 13 Pro using custom design approaches. Sonication time, homogenization speed, stirring rate, and cooling temperature were selected as factors for hot homogenization. Stirring speed, stirring time, and dilution volume were the factors deliberated for melt dispersion. The impact of these factors on the responses, particle size, and polydispersity index were studied. The nanoparticles were prepared according to the ten experimental runs generated by the design. Based on the responses, the design space and optimum framework were selected.  Results: The prediction profiler indicated maximum desirability at 81% and 80% for hot homogenization and melt dispersion respectively. The actual versus predicted plot of particle size indicated a regression coefficient (R2) of 0.98, and a p-value of 0.0001 for hot homogenization and for melt dispersion the corresponding values were 0.95 and 0.0003. For the response polydispersity index, these values were 0.92 and 0.0052 for hot homogenization and 0.90 and 0.0024 for melt dispersion. Conclusion: The endorsing results indicated the authenticity of the model in predicting the significant processing parameters for NLC.&nbsp

COMPARATIVE STUDIES WITH DIFFERENT CYCLODEXTRIN DERIVATIVES IN IMPROVING THE SOLUBILITY AND DISSOLUTION OF SAQUINAVIR

Objective: The present study was aimed to perform comparative studies with different cyclodextrin (CD) derivatives and to study the effect of different methods of preparation in improving the solubility and dissolution of saquinavir (SQV).Methods: Phase solubility studies were performed with beta CD (βCD), hydroxypropyl βCD, randomly methylated βCD, and sulfobutyl ether βCD (SBE7βCD). Complexes were prepared using physical mixture, coevaporation, kneading, spray drying, and freeze-drying techniques. For complexes prepared by spray drying, process parameters were optimized based on percentage yield. The prepared complexes were characterized using Fourier-transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction studies, nuclear magnetic resonance spectroscopy, and scanning electron microscopy. In vitro drug release study was conducted in phosphate buffer pH 6.8 and mean dissolution time (MDT) was calculated for all freeze-dried complexes.Results: Phase solubility studies showed a linear relationship with an increase in CD concentration and phase diagrams were of AL type. Highest stability constant was observed with SQV-SBE7βCD (8281.28/M). All characterization studies proved complexation. Among four CD derivatives, SQV complexed with SBE7βCD by freeze-drying showed maximum drug release and low MDT of 20.67.Conclusion: Among different CDs, SBE7βCD proved as ideal CD derivative, and among different methods of preparations, freeze-drying method was found to be useful in improving the solubility and dissolution of SQV

Security Enhancement using Color Based Alphanumeric on Cloud

Cloud computing is where computing resources are accessed from a virtual machine ?cloud? rather than a local desktop or organizational data center. While enjoying the convenience brought by this cloud, users also start worrying about losing control of their own data. The only solution is authentication. The password is the most common authentication method. Text based, patterns, pictographic and graphical passwords are suffering from some security attacks. This paper uses color code authentication in which the OTP is generated after the two steps of authentication. This color scheme tests with different kinds of security attacks. It is used for secure authentication for data protection in the cloud

Potential antioxidative protein-pigment complex Spirulina platensis mediated food grade phycocyanin C -Extraction, purification, antioxidative activity and biocompatibility

230-239Phycocyanin (PC), a photosynthetic pigment produced by cyanobacteria has been gained attention due to its distinct properties such as antioxidant and anti-proliferative. Acute and sub acute toxicity studies were carried out to determine the biocompatibility of the extracted phycocyanin on Wistar rat model. PC was extracted from Spirulina platensis biomass by cold maceration followed by successive purification by ammonium sulphate precipitation and gel filtration chromatography. Biocompatibility of the purified phycocyanin was carried out by acute toxicity studies using Wistar rat model. Acute toxicity has been determined by the effect of single oral dose of PC with two different concentrations (250 and 500 mg/Kg) on the body weight, general behaviour, and mortality. In sub-acute treatment. The effect of phycocyanin on the various parameters at the respective concentration as single oral dose daily during 28 days was studied. Cold maceration followed by maceration brought about food grade phycocyanin C (C-PC) which final yield and purity were increased in the successive purification steps. Antioxidative study using DPPH assay reveals the effective free scavenging activity of the phycocynin as concentration-dependent manner. Biocompatibility studies against Wister rat model did not exhibit any harmful effect. Any sign of toxic effect on biochemical, hematological and histopathological parameters was not observed in all the tested animals of treatment groups during the study period which reveals a high level of biocompatibility. The present study suggests the possible utilization of phycocyanin C as an effective pharmaceutical agent

Potential antioxidative protein-pigment complex Spirulina platensis mediated food grade phycocyanin C -Extraction, purification, antioxidative activity and biocompatibility

Phycocyanin (PC), a photosynthetic pigment produced by cyanobacteria has been gained attention due to its distinct properties such as antioxidant and anti-proliferative. Acute and sub acute toxicity studies were carried out to determine the biocompatibility of the extracted phycocyanin on Wistar rat model. PC was extracted from Spirulina platensis biomass by cold maceration followed by successive purification by ammonium sulphate precipitation and gel filtration chromatography. Biocompatibility of the purified phycocyanin was carried out by acute toxicity studies using Wistar rat model. Acute toxicity has been determined by the effect of single oral dose of PC with two different concentrations (250 and 500 mg/Kg) on the body weight, general behaviour, and mortality. In sub-acute treatment. The effect of phycocyanin on the various parameters at the respective concentration as single oral dose daily during 28 days was studied. Cold maceration followed by maceration brought about food grade phycocyanin C (C-PC) which final yield and purity were increased in the successive purification steps. Antioxidative study using DPPH assay reveals the effective free scavenging activity of the phycocynin as concentration-dependent manner. Biocompatibility studies against Wister rat model did not exhibit any harmful effect. Any sign of toxic effect on biochemical, hematological and histopathological parameters was not observed in all the tested animals of treatment groups during the study period which reveals a high level of biocompatibility. The present study suggests the possible utilization of phycocyanin C as an effective pharmaceutical agent