Comment on "Neutron Interferometric Observation of Noncyclic Phase"

A critique of a recent experiment [Wagh et.al., Phys.Rev.Lett.81, 1992 (7 Sep 1998)] to measure the noncyclic phase associated with a precessing neutron spin in a neutron interferometer, as given by the Pancharatnam criterion, is presented. It is pointed out that since the experiment measures, not the noncyclic phase itself, but a quantity derived from it, it misses the most interesting feature of such a phase, namely the different sign associated with states lying in the upper and the lower hemispheres, a feature originating in the existence of a phase singularity. Such effects have earlier been predicted and seen in optical interference experiments using polarization of light as the spinor [Bhandari, Phys.Rep.281, 1 (Mar 1997)].Comment: 5 pages, 0 figures, submitted to Phys.Rev.Let

Observable Dirac-type singularities in Berry's phase and the monopole

The physical reality and observability of 2n\pi Berry phases, as opposed to the usually considered modulo 2\pi topological phases is demonstrated with the help of computer simulation of a model adiabatic evolution whose parameters are varied along a closed loop in the parameter space. Using the analogy of Berry's phase with the Dirac monopole, it is concluded that an interferometer loop taken around a magnetic monopole of strength n/2 yields an observable 2n\pi phase shift, where n is an integer. An experiment to observe the effect is proposed.Comment: 12 pages Latex, 3 postscript figures; submitted to Physical Review Letters 15 September 2000; revised 19 November 200

Divergent mutational processes distinguish hypoxic and normoxic tumours.

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer

Relation between geometric phases of entangled bi-partite systems and their subsystems

This paper focuses on the geometric phase of entangled states of bi-partite systems under bi-local unitary evolution. We investigate the relation between the geometric phase of the system and those of the subsystems. It is shown that (1) the geometric phase of cyclic entangled states with non-degenerate eigenvalues can always be decomposed into a sum of weighted non-modular pure state phases pertaining to the separable components of the Schmidt decomposition, though the same cannot be said in the non-cyclic case, and (2) the geometric phase of the mixed state of one subsystem is generally different from that of the entangled state even by keeping the other subsystem fixed, but the two phases are the same when the evolution operator satisfies conditions where each component in the Schmidt decomposition is parallel transported

A Geological Appraisal of Slope Instability and Proposed Remedial Measures at Kaliasaur Slide on National Highway, Garwal Himalaya

For over six decades Kaliasaur landslide (Lat. 30° 14\u27 30 N, Long. 78° 55\u27 50 E) is a nightmare on the Hardwar-Badrinath road in the Garhwal Himalaya. Located on a sharp bend on the left bank of river Alaknanda, it has emerged as a multi-tier repetitive major landslide, retrogressive in nature. Both surficial and deep seated movements have been monitored. The sliding in the upper layers have been predominantly in the colluvium but where interfaces of quartzite and shale participates, the sliding surfaces have been better defined and discrete. In the present paper, the authors have highlighted the geological, geomorphological and morphometric parameters to diagnose the factors responsible for instability of slope and the magnitude of the problems involved. A scheme of remedial measures which .include modification of existing drainage pattern, timber piling for stitching of debris cover on to the slope, construction of retaining walls and putting back the vegetation on the slope are recommended for control of the landslide

On the half-life of 44Ti by results in meteorites

Measurements of the 44Ti half-life display a large spread ranging from 46.4 to 66.6 years. The activity of this radioisotope measured in eight meteorites (chondrites) fell in the time interval 1883-1992 and calculated at the time of fall by the different values of T1O2 shows that the shorter values are not reliable, if it is assumed that the average cosmic-ray intensity has remained the same during the past two centuries. The low activity of the cosmogenic isotope 44Ti has been determined by means of a selective Ge-NaI (Tl) g-spectrometer with a very low background (about 1 count per day in the g-peak at 1157 keV of 44Sc in equilibrium with its parent 44Ti). The high stability of this system allows long-lasting runs (A107 s ), in order to achieve the standard deviation of counting up to A10%. PACS 94.40.Vf – Cosmic-ray effects in meteorites and terrestrial matter

Cosmogenic radionuclides and tracks in the fresh fall portales valley

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