Numerical model estimation of biomethane production using an anaerobic CSTR: model formulation, parameter estimation and uncertainty/sensitivity analysis

Global climate change is becoming of increasing concern. Transportation makes up a large part of carbon gasses, which affects climate change and air quality. As transportation is a big part of carbon emissions, everybody can contribute to reducing emissions through transportation. One way for people to contribute is to start choosing greener transportation. Nuding is a tool that can be used to get people to choose greener transportation. It's function is to help guide people's behavior. For this project, the nudging goal is to nudge people towards healthier and greener transportation options than already in use. An example of a nudge is to provide reminders of bus departure times for a trip to an event. In order to nudge people gathering information relevant for traveling is necessary. In this thesis, relevant information for green transportation nudges is researched. Other studies on green transportation nudges are applied to discover relevant information topics and sources. Microservices architecture is proposed as the architecture for designing nudges, where the system is divided into smaller interconnected services that work together. Demonstrators of information collection microservices are designed and implemented. The demonstrators handle data for different information topics relevant to green transportation nudges. There are demonstrators for collecting weather data, routing data, public transportation data, rental bikes and scooters data, calendar data, and location data. The thesis also discusses how the data collected can be used to form transportation nudges

Asymptotic motion of a single vortex in a rotating cylinder

We study numerically the behavior of a single quantized vortex in a rotating cylinder. We study in particular the spiraling motion of a vortex in a cylinder that is parallel to the rotation axis. We determine the asymptotic form of the vortex and its axial and azimuthal propagation velocities under a wide range of parameters. We also study the stability of the vortex line and the effect of tilting the cylinder from the rotation axis.Comment: 9 pages, 10 figures. Considerable changes, now close to the published versio

Update of the Unitarity Triangle Analysis

We present the status of the Unitarity Triangle Analysis (UTA), within the Standard Model (SM) and beyond, with experimental and theoretical inputs updated for the ICHEP 2010 conference. Within the SM, we find that the general consistency among all the constraints leaves space only to some tension (between the UTA prediction and the experimental measurement) in BR(B -> tau nu), sin(2 beta) and epsilon_K. In the UTA beyond the SM, we allow for New Physics (NP) effects in (Delta F)=2 processes. The hint of NP at the 2.9 sigma level in the B_s-\bar B_s mixing turns out to be confirmed by the present update, which includes the new D0 result on the dimuon charge asymmetry but not the new CDF measurement of phi_s, being the likelihood not yet released.Comment: 4 pages, 2 figures, Proceedings of the 35th International Conference of High Energy Physics - ICHEP2010 (July 22-28, 2010, Paris

Vortex avalanches and the onset of superfluid turbulence

Quantized circulation, absence of Galilean invariance due to a clamped normal component, and the vortex mutual friction are the major factors that make superfluid turbulence behave in a way different from that in classical fluids. The model is developed for the onset of superfluid turbulence that describes the initial avalanche-like multiplication of vortices into a turbulent vortex tangle.Comment: 4 page

Coexistence of Single and Double-Quantum Vortex Lines

We discuss the configurations in which singly and doubly quantized vortex lines may coexist in a rotating superfluid. General principles of energy minimization lead to the conclusion that in equilibrium the two vortex species segregate within a cylindrical vortex cluster in two coaxial domains where the singly quantized lines are in the outer annular region. This is confirmed with simulation calculations on discrete vortex lines. Experimentally the coexistence can be studied in rotating superfluid $^3$He-A. With cw NMR techniques we find the radial distribution of the two vortex species to depend on how the cluster is prepared: (i) By cooling through $T_c$ in rotation, coexistence in the minimum energy configuration is confirmed. (ii) A glassy agglomerate is formed if one starts with an equilibrium cluster of single-quantum vortex lines and adds to it sequentially double-quantum lines, by increasing the rotation velocity in the superfluid state. This proves that the energy barriers, which separate different cluster configurations, are too high for metastabilities to anneal.Comment: 12 pages, 11 figures; Changed content, 15 pages, 14 figure

The Collaborative Development of New CFD Methods Adapted for Tilt Rotor Aircraft in the HiPerTilt Project

No abstract available

Vortex vs spinning string: Iordanskii force and gravitational Aharonov-Bohm effect

We discuss the transverse force acting on the spinning cosmic string, moving in the background matter. It comes from the gravitational Aharonov-Bohm effect and corresponds to the Iordanskii force acting on the vortex in superfluids, when the vortex moves with respect to the normal component of the liquid.Comment: Latex file, 9 pages, no figures, references are added, version submitted to JETP Let

Dynamic Remanent Vortices in Superfluid 3He-B

We investigate the decay of vortices in a rotating cylindrical sample of 3He-B, after rotation has been stopped. With decreasing temperature vortex annihilation slows down as the damping in vortex motion, the mutual friction dissipation \alpha(T), decreases almost exponentially. Remanent vortices then survive for increasingly long periods, while they move towards annihilation in zero applied flow. After a waiting period \Delta t at zero flow, rotation is reapplied and the remnants evolve to rectilinear vortices. By counting these lines, we measure at temperatures above the transition to turbulence ~0.6T_c the number of remnants as a function of \alpha(T) and \Delta t. At temperatures below the transition to turbulence T \lesssim 0.55 T_c, remnants expanding in applied flow become unstable and generate in a turbulent burst the equilibrium number of vortices. Here we measure the onset temperature T_on of turbulence as a function of \Delta t, applied flow velocity, and length of sample L.Comment: Submitted to the proceedings of the Quantum Fluids and Solids Conference 2006 (to be published in Journal of Low Temperature Physics 2007) New data are adde

A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours

Purpose: We performed a multi-centre phase I study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the orally available small molecule mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, WX-554, and to determine the optimal biological dose for subsequent trials. Experimental design: Patients with treatment-refractory, advanced solid tumours, with adequate performance status and organ function were recruited to a dose-escalation study in a standard 3 + 3 design. The starting dose was 25 mg orally once weekly with toxicity, PK and PD guided dose-escalation with potential to explore alternative schedules. Results: Forty-one patients with advanced solid tumours refractory to standard therapies and with adequate organ function were recruited in eight cohorts up to doses of 150 mg once weekly and 75 mg twice weekly. No dose-limiting toxicities were observed during the study, and a maximum tolerated dose (MTD) was not established. The highest dose cohorts demonstrated sustained inhibition of extracellular signal-regulated kinase (ERK) phosphorylation in peripheral blood mononuclear cells following ex-vivo phorbol 12-myristate 13-acetate stimulation. There was a decrease of 70 ± 26% in mean phosphorylated (p)ERK in C1 day 8 tumour biopsies when compared with pre-treatment tumour levels in the 75 mg twice a week cohort. Prolonged stable disease (>6 months) was seen in two patients, one with cervical cancer and one with ampullary carcinoma. Conclusions: WX-554 was well tolerated, and an optimal biological dose was established for further investigation in either a once or twice weekly regimens. The recommended phase 2 dose is 75 mg twice weekly