74 research outputs found
Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics
Get PDFHeat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler’s diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C). Advances in understanding the biology of GC-C have extended ST from a diarrheagenic peptide to a novel therapeutic agent. Here, we summarize the physiological and pathophysiological role of GC-C in fluid-electrolyte regulation and intestinal crypt-villus homeostasis, as well as describe translational opportunities offered by STs, reflecting the unique characteristics of GC-C, in treating irritable bowel syndrome and chronic constipation, and in preventing and treating colorectal cancer
Diagnostics and treatment of respiratory tract infections (excluding community-acquired pneumonia) in outpatient treated children without severe underlying diseases
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The ¤effect of alfa-trinositol on cholera toxin-induced hypersecretion and morphological changes in pig jejunum
No full textInvolvement of 5-hydroxytryptamine and prostaglandin E2 in the intestinal secretory action of Escherichia coli heat-stable enterotoxin B
No full textLoperamide reduces the intestinal secretion but not the mucosal cAMP accumulation induced by choleratoxin
No full textEffects of bisacodyl on cAMP and prostaglandin E2 contents, (Na+K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestine
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