Dificultades y posibilidades del algoritmo de optimización de enjambre de partículas para la planificación contemporánea espacial del bosque

We describe here an example of applying particle swarm optimization (PSO) — a population-based heuristic technique — to maximize the net present value of a contemporary southern United States forest plan that includes spatial constraints (green-up and adjacency) and wood flow constraints. When initiated with randomly defined feasible initial conditions, and tuned with some appropriate modifications, the PSO algorithm gradually converged upon its final solution and provided reasonable objective function values. However, only 86% of the global optimal value could be achieved using the modified PSO heuristic. The results of this study suggest that under random-start initial population conditions the PSO heuristic may have rather limited application to forest planning problems with economic objectives, wood-flow constraints, and spatial considerations. Pitfalls include the need to modify the structure of PSO to both address spatial constraints and to repair particles, and the need to modify some of the basic assumptions of PSO to better address contemporary forest planning problems. Our results, and hence our contributions, are contrary to earlier work that illustrated the impressive potential of PSO when applied to stand-level forest planning problems or when applied to a high quality initial population.Se describe aquí un ejemplo de la aplicación de la optimización de enjambre de partículas (PSO) — una técnica heurística basada en la población — para maximizar el valor presente neto de un moderno plan de gestión del bosque del sur de los Estados Unidos, que incluye limitaciones espaciales y restricciones del flujo de madera. Cuando se inicia con condiciones iniciales factibles definidas aleatoriamente, y en sintonía con algunas modificaciones adecuadas, el algoritmo PSO converge gradualmente sobre su solución final y suministra los valores de la función objetivo. Sin embargo, sólo el 86% del valor global óptimo podría lograrse usando la heurística PSO modificada. Los resultados de este estudio sugieren que bajo condiciones de arranque aleatorio de la población inicial, la heurística PSO puede tener una aplicación más bien limitada a los problemas de planificación forestal con objetivos económicos, restricciones de flujo de madera y consideraciones espaciales. Las dificultadas incluyen la necesidad de modificar la estructura de PSO para abordar tanto las limitaciones espaciales como para reparar las partículas, y la necesidad de modificar algunos de los supuestos básicos de PSO para abordar mejor los problemas contemporáneos de la planificación forestal. Nuestros resultados, y por lo tanto nuestra aportación, son contrarios a trabajos anteriores que ilustran el impresionante potencial de PSO cuando se aplica a problemas de planificación forestal a nivel de rodal o cuando se aplica a una población de calidad inicial alta

Redating shuidonggou locality 1 and implications for the initial upper paleolithic in east asia

A review of recently published temporal data from Shuidonggou Locality 1 indicates that a 40-43 cal ka date for the inception of Initial Upper Paleolithic (IUP) blade-oriented technologies in East Asia is warranted. Comparison of the dates from Shuidonggou to other Asian IUP dates in Korea, Siberia, and Mongolia supports this assertion, indicating that the initial appearance of the IUP in East Asia generally corresponds in time to the fluorescence of the IUP in eastern Europe and western Asia. This conclusion preliminarily suggests that either a version of the IUP originated independently in East Asia just prior to 40 cal ka, or more likely, that an early, initial diffusion of the IUP into East Asia occurred ~41 cal ka, a hypothesis consistent with current estimates for the evolution or arrival of modern humans in the region. © 2014 by the Arizona Board of Regents on behalf of the University of Arizona

Zero-order controlled release of ciprofloxacin-HCl from a reservoir-based, bioresorbable and elastomeric device

A reservoir-based device constructed of a completely biodegradable elastomer can enable several new implantation and insertion options for localized drug therapy, particularly in the case of urological therapies. We performed an in vitro performance evaluation of an implantable, bio-resorbable device that supplies short-term controlled release of ciprofloxacin-HCl (CIP). The proposed device functions through a combination of osmosis and diffusion mechanisms to release CIP for short-term therapies of a few weeks duration. Poly(glycerol-co-sebacic acid) (PGS) was cast in a tubular geometry with solid drug powder packed into its core and a micro-machined release orifice drilled through its wall. Drug release experiments were performed to determine the effective release rate from a single orifice and the range of orifice sizes in which controlled zero-order release was the main form of drug expulsion from the device. It is demonstrated that PGS is sufficiently permeable to water to allow the design of an elementary osmotic pump for drug delivery. Indeed, PGS's water permeability is several orders of magnitude larger than commonly used cellulose acetate for elementary osmotic pumps.Deshpande Center for Technological InnovationSamsung Scholarship Foundatio

Long-Chain ω-3 Levels Are Associated With Increased Alcohol Sensitivity in a Population-Based Sample of Adolescents.

BackgroundThe levels of the ω-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been associated with alcohol sensitivity in vertebrate and invertebrate model systems, but prior studies have not examined this association in human samples despite evidence of associations between ω-3 LC-PUFA levels and alcohol-related phenotypes. Both alcohol sensitivity and ω-3 LC-PUFA levels are impacted by genetic factors, and these influences may contribute to observed associations between phenotypes. Given the potential for using EPA and DHA supplementation in adjuvant care for alcohol misuse and other outcomes, it is important to clarify how ω-3 LC-PUFA levels relate to alcohol sensitivity.MethodsAnalyses were conducted using data from the Avon Longitudinal Study of Parents and Children. Plasma ω-3 LC-PUFA levels were measured at ages 15.5 and 17.5. Participants reported on their initial alcohol sensitivity using the early drinking Self-Rating of the Effects of Alcohol (SRE-5) scale, for which more drinks needed for effects indicates lower levels of response per drink, at ages 15.5, 16.5, and 17.5. Polygenic liability for alcohol consumption, alcohol problems, EPA levels, and DHA levels was derived using summary statistics from large, publicly available datasets. Linear regressions were used to examine the cross-sectional and longitudinal associations between ω-3 LC-PUFA levels and SRE scores.ResultsAge 15.5 ω-3 LC-PUFA levels were negatively associated with contemporaneous SRE scores and with age 17.5 SRE scores. One modest association (p = 0.02) between polygenic liability and SRE scores was observed, between alcohol problems-based polygenic risk scores (PRS) and age 16.5 SRE scores. Tests of moderation by genetic liability were not warranted.ConclusionsPlasma ω-3 LC-PUFA levels may be related to initial sensitivity to alcohol during adolescence. These data indicate that diet-related factors have the potential to impact humans' earliest responses to alcohol exposure

Stone-Wales Transformation Paths in Fullerene C60

The mechanisms of formation of a metastable defect isomer of fullerene C60 due to the Stone-Wales transformation are theoretically studied. It is demonstrated that the paths of the "dynamic" Stone-Wales transformation at a high sufficient for overcoming potential barriers) temperature can differ from the two "adiabatic" transformation paths discussed in the literature. This behavior is due to the presence of a great near-flat segment of the potential-energy surface in the neighborhood of metastable states. Besides, the sequence of rupture and formation of interatomic bonds is other than that in the case of the adiabatictransformation.Comment: 10 pages, 6 figure

Contrasting influences of Drosophila white/mini-white on ethanol sensitivity in two different behavioral assays

Background The fruit fly Drosophila melanogaster has been used extensively to investigate genetic mechanisms of ethanol-related behaviors. Many past studies in flies, including studies from our laboratory, have manipulated gene expression using transposons carrying the genetic-phenotypic marker mini-white, a derivative of the endogenous gene white. Whether the mini-white transgenic marker or the endogenous white gene influence behavioral responses to acute ethanol exposure in flies has not been systematically investigated. Methods We manipulated mini-white and white expression via (i) transposons marked with mini-white, (ii) RNAi against mini-white and white and (iii) a null allele of white. We assessed ethanol sensitivity and tolerance using a previously described eRING assay (based on climbing in the presence of ethanol) and an assay based on ethanol-induced sedation. Results In eRING assays, ethanol-induced impairment of climbing correlated inversely with expression of the mini-white marker from a series of transposon insertions. Additionally, flies harboring a null allele of white or flies with RNAi-mediated knockdown of mini-white were significantly more sensitive to ethanol in eRING assays than controls expressing endogenous white or the mini-white marker. In contrast, ethanol sensitivity and rapid tolerance measured in the ethanol sedation assay were not affected by decreased expression of mini-white or endogenous white in flies. Conclusions Ethanol sensitivity measured in the eRING assay is noticeably influenced by white and mini-white, making eRING problematic for studies on ethanol-related behavior in Drosophila using transgenes marked with mini-white. In contrast, the ethanol sedation assay described here is a suitable behavioral paradigm for studies on ethanol sedation and rapid tolerance in Drosophila including those that use widely available transgenes marked with mini-white