Techno-Economic and Life Cycle Assessment of Hydrothermal Processing of Microalgae for Biofuels and Co-Product Generation

Traditional processing methods of algae to biofuels require dewatering after harvesting of the algae before the lipids can be extracted. This is typically the most energy intensive and therefore the most expensive step. Old Dominion University (ODU) has successfully utilized a flash hydrolysis (a kind of hydrothermal) process where proteins are solubilized into the liquid phase of product and the remainder lipid-rich, low nitrogen product is separated into a solid phase. The solid phase (lipid-rich) is then an ideal candidate for biofuel feedstock and the liquid phase, or hydrolysate, can be used for coproducts such as a source of nutrients for new batches of algal cultivation or fertilizer production. The importance of this research lies within the energy conservation associated with the flash hydrolysis process, the quality of the co-products that are generated during the flash hydrolysis process, and the subsequent processing methods utilized to recover the nutrients not directly used for biofuel products. Processes which complement each other in the processing of microalgae to biofuel must be utilized for improving life cycle assessment (LCA) and technoeconomic analysis (TEA) results. These LCA and TEA data are critical for investors in both the public and private sectors. A valuable return on investment must be quantified in order for investors to move forward with advanced biofuels production. A combination of resources are utilized in this dissertation to quantify the LCA and TEA of the hydrothermal processes that are utilized in the ODU Biomass Research Laboratory (BRL) which include Argonne National Laboratory GREET, SuperPro Designer, Aspen Plus, and SimaPro’s Ecoinvent databases. This dissertation evaluates the novel processes researched in the BRL from the microscopic flash hydrolysis process level to a community level macroscopic evaluation. The clarity of how the flash hydrolysis compares with other hydrothermal processes is studied by conducting a LCA comparison. The flash hydrolysis process is then modeled utilizing two different microalgae species with varying cultivation and nutrient extraction properties. The alternate downstream processing methods for recovering preserved nutrients is then modeled for LCA and TEA results in order to quantify how coproduct generation offsets energy costs associated with algae biofuel processing. The final chapter of this dissertation utilizes the LCA and TEA results captured within the preceding assessments to develop a sustainable community model with algae cultivation and downstream processing at the focus of the sustainable community and an ultimate goal of zero net energy and zero waste system boundaries for the community

Space suit

A pressure suit for high altitude flights, particularly space missions is reported. The suit is designed for astronauts in the Apollo space program and may be worn both inside and outside a space vehicle, as well as on the lunar surface. It comprises an integrated assembly of inner comfort liner, intermediate pressure garment, and outer thermal protective garment with removable helmet, and gloves. The pressure garment comprises an inner convoluted sealing bladder and outer fabric restraint to which are attached a plurality of cable restraint assemblies. It provides versitility in combination with improved sealing and increased mobility for internal pressures suitable for life support in the near vacuum of outer space

Experiments and 3D simulations of flow structures in junctions and their influence on location of flowmeters

International audienceOpen-channel junctions are common occurrences in sewer networks and flow rate measurement often occurs near these singularities. Local flow structures are 3-dimensional, impact on the representativeness of the local flow measurements and thus lead to deviations in the flow rate estimation. The present study aims i) to measure and simulate the flow pattern in a junction flow, ii) to analyze the impact of the junction on the velocity distribution according to the distance from the junction and thus iii) to evaluate the typical error derived from the computation of the flow rate close to the junction

Harmful and beneficial symbionts of Tenebrio molitor and their implications for disease management

The yellow mealworm, Tenebrio molitor, is currently one of the most important insect species produced for livestock feed and human consumption. High-density rearing conditions make the risk of disease and infections by parasitic symbionts a challenge in the mass production of these insects. However, certain symbionts are beneficial and should be favoured in order to promote healthy insect populations. Knowledge of parasitic symbionts and their management is essential for the insect rearing industry and its associated research. Here we review the documented microbial infectious agents, invertebrate parasites, and beneficial symbionts occurring in T. molitor. Furthermore, we discuss detection, prevention, and treatment methods for disease management in T. molitor production systems to inform future management and decision making in T. molitor rearing

Optimisation of ITER Nb3Sn CICCs for coupling loss, transverse electromagnetic load and axial thermal contraction

The ITER cable-in-conduit conductors (CICCs) are built up from sub-cable bundles, wound in different stages, which are twisted to counter coupling loss caused by time-changing external magnet fields. The selection of the twist pitch lengths has major implications for the performance of the cable in the case of strain sensitive superconductors, i.e. Nb3Sn, as the electromagnetic and thermal contraction loads are large but also for the heat load from the AC coupling loss. Reduction of the transverse load and warm-up cool-down degradation can be reached by applying longer twist pitches in a particular sequence for the sub-stages, offering a large cable transverse stiffness, adequate axial flexibility and maximum allowed lateral strand support. Analysis of short sample (TF conductor) data reveals that increasing the twist pitch can lead to a gain of the effective axial compressive strain of more than 0.3 % with practically no degradation from bending. For reduction of the coupling loss, specific choices of the cabling twist sequence are needed with the aim to minimize the area of linked strands and bundles that are coupled and form loops with the applied changing magnetic field, instead of simply avoiding longer pitches. In addition we recommend increasing the wrap coverage of the CS conductor from 50 % to at least 70 %. The models predict significant improvement against strain sensitivity and substantial decrease of the AC coupling loss in Nb3Sn CICCs, but also for NbTi CICCs minimization of the coupling loss can be achieved. Although the success of long pitches to transverse load degradation was already demonstrated, the prediction of the combination with low coupling loss needs to be validated by a short sample test.Comment: to be published in Supercond Sci Techno

Modeling the Influence of Vitamin D Deficiency on Cigarette Smoke-Induced Emphysema

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. While the primary risk factor for COPD is cigarette smoke exposure, vitamin D deficiency has been epidemiologically implicated as a factor in the progressive development of COPD-associated emphysema. Because of difficulties inherent to studies involving multiple risk factors in the progression of COPD in humans, we developed a murine model in which to study the separate and combined effects of vitamin D deficiency and cigarette smoke exposure. During a 16-week period, mice were exposed to one of four conditions, control diet breathing room air (CD-NS), control diet with cigarette smoke exposure (CD-CSE), vitamin D deficient diet breathing room air (VDD-NS) or vitamin D deficient diet with cigarette smoke exposure (VDD-CSE). At the end of the exposure period, the lungs were examined by a pathologist and separately by morphometric analysis. In parallel experiments, mice were anesthetized for pulmonary function testing followed by sacrifice and analysis. Emphysema (determined by an increase in alveolar mean linear intercept length) was more severe in the VDD-CSE mice compared to control animals and animals exposed to VDD or CSE alone. The VDD-CSE and the CD-CSE mice had increased total lung capacity and increased static lung compliance. There was also a significant increase in the matrix metalloproteinase-9: tissue inhibitor of metalloproteinases-1 (TIMP-1) ratio in VDD-CSE mice compared with all controls. Alpha-1 antitrypsin (A1AT) expression was reduced in VDD-CSE mice as well. In summary, vitamin D deficiency, when combined with cigarette smoke exposure, seemed to accelerate the appearance of emphysemas, perhaps by virtue of an increased protease-antiprotease ratio in the combined VDD-CSE animals. These results support the value of our mouse model in the study of COPD

Developmental changes in resting‐state functional networks among individuals with and without internalizing psychopathologies

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147755/1/da22864.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147755/2/da22864_am.pd

Long-term safety in patients with recurrent ovarian cancer treated with niraparib versus placebo: Results from the phase III ENGOT-OV16/NOVA trial

OBJECTIVE: Niraparib is a poly(ADP-ribose) polymerase (PARP) inhibitor approved for use in heavily pretreated patients and as maintenance treatment in patients with newly-diagnosed or recurrent ovarian cancer following a response to platinum-based chemotherapy. We present long-term safety data for niraparib from the ENGOT-OV16/NOVA trial. METHODS: This multicenter, double-blind, randomized, controlled phase III trial evaluated the efficacy and safety of niraparib for the treatment of recurrent ovarian cancer. Patients were randomly assigned 2:1 to receive either once-daily niraparib 300 mg or placebo. Two independent cohorts were enrolled based on germline BRCA mutation status. The primary endpoint was progression-free survival, reported previously. Long-term safety data were from the most recent data cutoff (September 2017). RESULTS: Overall, 367 patients received niraparib 300 mg once daily. Dose reductions due to TEAEs were highest in month 1 (34%) and declined every month thereafter. Incidence of any-grade and grade ≥ 3 hematologic and symptomatic TEAEs was also highest in month 1 and subsequently declined. Incidence of grade ≥ 3 thrombocytopenia decreased from 28% (month 1) to 9% and 5% (months 2 and 3, respectively), with protocol-directed dose interruptions and/or reductions. Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) were reported in 2 and 6 niraparib-treated patients, respectively, and in 1 placebo patient each. Treatment discontinuations due to TEAEs were <5% in each month and time interval measured. CONCLUSION: These data demonstrate the importance of appropriate dose reduction according to toxicity criteria and support the safe long-term use of niraparib for maintenance treatment in patients with recurrent ovarian cancer. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01847274

A prospective study of prognostic factors for duration of sick leave after endoscopic carpal tunnel release

<p>Abstract</p> <p>Background</p> <p>Endoscopic carpal tunnel release with a single portal technique has been shown to reduce sick leave compared to open carpal tunnel release, claiming to be a less invasive procedure and reducing scar tenderness leading to a more rapid return to work, and the purpose of this study was to identify prognostic factors for prolonged sick leave after endoscopic carpal tunnel release in a group of employed Danish patients.</p> <p>Methods</p> <p>The design was a prospective study including 75 employed patients with carpal tunnel syndrome operated with ECTR at two hospitals. The mean age was 46 years (SD 10.1), the male/female ratio was 0.42, and the mean preoperative duration of symptoms 10 months (range 6-12). Only 21 (28%) were unable to work preoperatively and mean sick leave was 4 weeks (range 1-4). At base-line and at the 3-month follow-up, a self-administered questionnaire was collected concerning physical, psychological, and social circumstances in relation to the hand problem. Data from a nerve conduction examination were collected at baseline and at the 3-month follow-up. Significant prognostic factors were identified through multiple logistic regression analysis.</p> <p>Results</p> <p>After the operation, the mean functional score was reduced from 2.3 to 1.4 (SD 0.8) and the mean symptom score from 2.9 to 1.5 (SD 0.7). The mean sick leave from work after the operation was 19.8 days (SD 14.3). Eighteen patients (24%) had more than 21 days of sick leave. Two patients (3%) were still unable to work after 3 months. Significant prognostic factors in the multivariate analysis for more than 21 days of postoperative sick leave were preoperative sick leave, blaming oneself for the hand problem and a preoperative distal motor latency.</p> <p>Conclusion</p> <p>Preoperative sick leave, blaming oneself for the hand problem, and a preoperative distal nerve conduction motor latency were prognostic factors for postoperative work absence of more than 21 days. Other factors may be important (clinical, demographic, economic, and workplace) in explaining the great variance in the results of sick leave after carpal tunnel release between studies from different countries.</p