Nonlinear stability of the Taub-NUT soliton in 6+1 dimensions

Using mixed numerical and analytical methods we give evidence that the 6+1 dimensional Taub-NUT soliton is asymptotically nonlinearly stable against small perturbations preserving biaxial Bianchi IX symmetry. We also show that for sufficiently strong perturbations the soliton collapses to a warped black hole. Since this black hole solution is not known in closed form, for completeness of the exposition we prove its existence and determine its properties. In particular, the mass of the black hole is computed.Comment: 19 pages, 5 figure

Geometric invariance of mass-like asymptotic invariants

We study coordinate-invariance of some asymptotic invariants such as the ADM mass or the Chru\'sciel-Herzlich momentum, given by an integral over a "boundary at infinity". When changing the coordinates at infinity, some terms in the change of integrand do not decay fast enough to have a vanishing integral at infinity; but they may be gathered in a divergence, thus having vanishing integral over any closed hypersurface. This fact could only be checked after direct calculation (and was called a "curious cancellation"). We give a conceptual explanation thereof.Comment: 13 page

A Metric for Gradient RG Flow of the Worldsheet Sigma Model Beyond First Order

Tseytlin has recently proposed that an action functional exists whose gradient generates to all orders in perturbation theory the Renormalization Group (RG) flow of the target space metric in the worldsheet sigma model. The gradient is defined with respect to a metric on the space of coupling constants which is explicitly known only to leading order in perturbation theory, but at that order is positive semi-definite, as follows from Perelman's work on the Ricci flow. This gives rise to a monotonicity formula for the flow which is expected to fail only if the beta function perturbation series fails to converge, which can happen if curvatures or their derivatives grow large. We test the validity of the monotonicity formula at next-to-leading order in perturbation theory by explicitly computing the second-order terms in the metric on the space of coupling constants. At this order, this metric is found not to be positive semi-definite. In situations where this might spoil monotonicity, derivatives of curvature become large enough for higher order perturbative corrections to be significant.Comment: 15 pages; Erroneous sentence in footnote 14 removed; this version therefore supersedes the published version (our thanks to Dezhong Chen for the correction

On the Bartnik extension problem for the static vacuum Einstein equations

We develop a framework for understanding the existence of asymptotically flat solutions to the static vacuum Einstein equations with prescribed boundary data consisting of the induced metric and mean curvature on a 2-sphere. A partial existence result is obtained, giving a partial resolution of a conjecture of Bartnik on such static vacuum extensions. The existence and uniqueness of such extensions is closely related to Bartnik's definition of quasi-local mass.Comment: 33 pages, 1 figure. Minor revision of v2. Final version, to appear in Class. Quantum Gravit

Clustering Time-Series Gene Expression Data Using Smoothing Spline Derivatives

Microarray data acquired during time-course experiments allow the temporal variations in gene expression to be monitored. An original postprandial fasting experiment was conducted in the mouse and the expression of 200 genes was monitored with a dedicated macroarray at 11 time points between 0 and 72 hours of fasting. The aim of this study was to provide a relevant clustering of gene expression temporal profiles. This was achieved by focusing on the shapes of the curves rather than on the absolute level of expression. Actually, we combined spline smoothing and first derivative computation with hierarchical and partitioning clustering. A heuristic approach was proposed to tune the spline smoothing parameter using both statistical and biological considerations. Clusters are illustrated a posteriori through principal component analysis and heatmap visualization. Most results were found to be in agreement with the literature on the effects of fasting on the mouse liver and provide promising directions for future biological investigations

On vacuum gravitational collapse in nine dimensions

We consider the vacuum gravitational collapse for cohomogeneity-two solutions of the nine dimensional Einstein equations. Using combined numerical and analytical methods we give evidence that within this model the Schwarzschild-Tangherlini black hole is asymptotically stable. In addition, we briefly discuss the critical behavior at the threshold of black hole formation.Comment: 4 pages, 4 figure

A Barren Landscape?

We consider the generation of a non-perturbative superpotential in F-theory compactifications with flux. We derive a necessary condition for the generation of such a superpotential in F-theory. For models with a single volume modulus, we show that the volume modulus is never stabilized by either abelian instantons or gaugino condensation. We then comment on how our analysis extends to a larger class of compactifications. From our results, it appears that among large volume string compactifications, metastable de Sitter vacua (should any exist) are non-generic.Comment: 14 pages, comments adde

Platelet-activating factor acetylhydrolase and haemophagocytosis in the sepsis syndrome.

Sepsis syndrome (SS) is associated with depressed PAF acetylhydrolase, the enzyme responsible for the degradation of platelet activating factor. PAF acetylhydrolase is in a large part produced by macrophages, whose inadequate activation with haemophagocytosis is frequent in patients with SS. The aim of this study was to test the hypothesis that PAF acetylhydrolase levels could be affected in these critically ill patients, because of the large amounts produced by activated macrophages in vitro and in vivo in animal models. The levels of serum PAF acetylhydrolase were assessed in 90 SS patients, who were divided into three groups: patients with (n = 34) or without haemophagocytosis (n = 31), and patients without thrombocytopenia (n = 25) who were used as a control group. The number of organ dysfunctions was matched between patients with haemophagocytosis and controls. Normal reference values were obtained in 59 randomly selected blood donors. Circulating levels of PAF acetylhydrolase were significantly (p = 0.0001) decreased in patients with SS (57+/-3 nmol/ml/min, n = 90) when compared with healthy subjects (69+/-3 nmol/ml/min, n = 59). PAF acetylhydrolase levels were greater in the presence of a haemophagocytosis but without statistical significance (64.2+/-6.5 vs. 50.1+/-2.8:p = 0.25). Despite the fact that macrophagic activation stimulates the in vitro release of PAF acetylhydrolase, no difference was found between patients with or without haemophagocytosis. The mechanism and the role of the PAF acetylhydrolase reduction in SS patients remain to be determined

On the stability and spectrum of non-supersymmetric AdS(5) solutions of M-theory compactified on Kahler-Einstein spaces

Eleven-dimensional supergravity admits non-supersymmetric solutions of the form AdS(5)xM(6) where M(6) is a positive Kahler-Einstein space. We show that the necessary and sufficient condition for such solutions to be stable against linearized bosonic supergravity perturbations can be expressed as a condition on the spectrum of the Laplacian acting on (1,1)-forms on M(6). For M(6)=CP(3), this condition is satisfied, although there are scalars saturating the Breitenlohner-Freedman bound. If M(6) is a product S(2)xM(4) (where M(4) is Kahler-Einstein) then there is an instability if M(4) has a continuous isometry. We show that a potential non-perturbative instability due to 5-brane nucleation does not occur. The bosonic Kaluza-Klein spectrum is determined in terms of eigenvalues of operators on M(6).Comment: 21 pages. v2: Includes SU(4) quantum numbers for CP3 case, typos fixed, refs adde

Compact conformally Kahler Einstein-Weyl manifolds

We give a classification of compact conformally Kahler Einstein-Weyl manifolds whose Ricci tensor is hermitian.Comment: 11 page