1,036 research outputs found
Filling the Void: A Low Cost, High-Yield Method to Addressing Incidental Findings in Trauma Patients
In this study we:
Report the incidence of incidental findings in a suburban trauma center treating primarily blunt and elderly trauma
Propose simple solutions to increase the rate of disclosure to patientshttps://jdc.jefferson.edu/patientsafetyposters/1070/thumbnail.jp
Group properties and invariant solutions of a sixth-order thin film equation in viscous fluid
Using group theoretical methods, we analyze the generalization of a
one-dimensional sixth-order thin film equation which arises in considering the
motion of a thin film of viscous fluid driven by an overlying elastic plate.
The most general Lie group classification of point symmetries, its Lie algebra,
and the equivalence group are obtained. Similar reductions are performed and
invariant solutions are constructed. It is found that some similarity solutions
are of great physical interest such as sink and source solutions,
travelling-wave solutions, waiting-time solutions, and blow-up solutions.Comment: 8 page
Kinematic evaluation of physical impairments of an elite Paralympic karateka
Karate is a Japanese martial art that counts millions of practitioners worldwide and that is spreading also in Paralympic competitions, requiring accurate categories definition for disabled athletes. The aim of the study is to present kinematic data of an elite Paralympic karateka, in comparison with able-bodied athletes. The authors also aim to promote a better classification within the discipline, based on objective biomechanical evaluations of physical impairments. A male black belt Paralympic karateka (age: 36 y; body weight: 75.5 kg; height: 173 cm) with lower limbs impairments was evaluated. The athlete had been performing high level karate for 20 years before the disability took place. After the post-operative rehabilitation, he attended 3/4 sessions of para- karate training per week. He performed a standardized sequence of movements, involving a sequence of offensive and defensive techniques, (kata) from traditional Shotokan karate. Joints and body Center of Mass (CoM) kinematics were collected with an optoelectronic motion capture system and compared with those obtained in two groups of able-bodied (elite and amateurs) athletes from a previous study1. Knee angular range of motion (RoM) and peak angular velocity were obtained. Coordinates of CoM were estimated, using the Segmental Centroid Method2, along with CoM average velocity and acceleration. To assess differences between Paralympic karateka and able-bodied groups, the one-sample t-test was performed. The sequence performed by the karateka lasted more than in both able-bodied groups. CoM average velocity and acceleration decreased in comparison with elite karateka. Knees range of movement and peak angular velocity were similar to amateur but lower than elite athletes. Results show that the physical impairments negatively affected the function of lower limbs in the Paralympic athlete. Fundamental skills in karate elite performance (dynamic balance control and joint RoM and angular velocity) were reduced
Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults
Regular endurance exercise training is an effective intervention for the maintenance of metabolic health and the prevention of many age-associated chronic diseases. Several metabolic and inflammatory factors are involved in the health-promoting effects of exercise training, but regulatory mechanisms remain poorly understood. Cellular senescenceâa state of irreversible growth arrestâis considered a basic mechanism of aging. Senescent cells accumulate over time and promote a variety of age-related pathologies from neurodegenerative disorders to cancer. Whether long-term intensive exercise training affect the accumulation of age-associated cellular senescence is still unclear. Here, we show that the classical senescence markers p16 and IL-6 were markedly higher in the colon mucosa of middle-aged and older overweight adults than in young sedentary individuals, but this upregulation was significantly blunted in age-matched endurance runners. Interestingly, we observe a linear correlation between the level of p16 and the triglycerides to HDL ratio, a marker of colon adenoma risk and cardiometabolic dysfunction. Our data suggest that chronic high-volume high-intensity endurance exercise can play a role in preventing the accumulation of senescent cells in cancer-prone tissues like colon mucosa with age. Future studies are warranted to elucidate if other tissues are also affected, and what are the molecular and cellular mechanisms that mediate the senopreventative effects of different forms of exercise training
Thin film evolution equations from (evaporating) dewetting liquid layers to epitaxial growth
In the present contribution we review basic mathematical results for three
physical systems involving self-organising solid or liquid films at solid
surfaces. The films may undergo a structuring process by dewetting,
evaporation/condensation or epitaxial growth, respectively. We highlight
similarities and differences of the three systems based on the observation that
in certain limits all of them may be described using models of similar form,
i.e., time evolution equations for the film thickness profile. Those equations
represent gradient dynamics characterized by mobility functions and an
underlying energy functional.
Two basic steps of mathematical analysis are used to compare the different
system. First, we discuss the linear stability of homogeneous steady states,
i.e., flat films; and second the systematics of non-trivial steady states,
i.e., drop/hole states for dewetting films and quantum dot states in epitaxial
growth, respectively. Our aim is to illustrate that the underlying solution
structure might be very complex as in the case of epitaxial growth but can be
better understood when comparing to the much simpler results for the dewetting
liquid film. We furthermore show that the numerical continuation techniques
employed can shed some light on this structure in a more convenient way than
time-stepping methods.
Finally we discuss that the usage of the employed general formulation does
not only relate seemingly not related physical systems mathematically, but does
as well allow to discuss model extensions in a more unified way
Transmission of High-Power Electron Beams Through Small Apertures
Tests were performed to pass a 100 MeV, 430 kWatt c.w. electron beam from the
energy-recovery linac at the Jefferson Laboratory's FEL facility through a set
of small apertures in a 127 mm long aluminum block. Beam transmission losses of
3 p.p.m. through a 2 mm diameter aperture were maintained during a 7 hour
continuous run.Comment: arXiv admin note: text overlap with arXiv:1305.019
The McKean-Vlasov Equation in Finite Volume
We study the McKean--Vlasov equation on the finite tori of length scale
in --dimensions. We derive the necessary and sufficient conditions for the
existence of a phase transition, which are based on the criteria first
uncovered in \cite{GP} and \cite{KM}. Therein and in subsequent works, one
finds indications pointing to critical transitions at a particular model
dependent value, of the interaction parameter. We show that
the uniform density (which may be interpreted as the liquid phase) is
dynamically stable for and prove, abstractly, that a
{\it critical} transition must occur at . However for
this system we show that under generic conditions -- large, and
isotropic interactions -- the phase transition is in fact discontinuous and
occurs at some \theta\t < \theta^{\sharp}. Finally, for H--stable, bounded
interactions with discontinuous transitions we show that, with suitable
scaling, the \theta\t(L) tend to a definitive non--trivial limit as
Implementation of a Three-Semester Concurrent Engineering Design Sequence for Lower-Division Engineering Students
Over the past decade the software products available for solid modeling, dynamic, stress, thermal, and flow analysis, and computer-aiding manufacturing (CAM) have become more powerful, affordable, and easier to use. At the same time it has become increasingly important for students to gain concurrent engineering design and systems integration experience. The purpose of this paper is to communicate the dramatic effect that the new software has had on the way that mechanical drawing and engineering design are taught at Daniel Webster College (DWC). The two year design experience at DWC is more extensive than the design experience that students normally have during the first two years of most four-year engineering programs. The evolution of this design experience will be presented. Three of the presenters of this paper are students. Two will present robotic arm projects; the third will present a supersonic gun project
Measured Radiation and Background Levels During Transmission of Megawatt Electron Beams Through Millimeter Apertures
We report measurements of photon and neutron radiation levels observed while
transmitting a 0.43 MW electron beam through millimeter-sized apertures and
during beam-off, but accelerating gradient RF-on, operation. These measurements
were conducted at the Free-Electron Laser (FEL) facility of the Jefferson
National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an
energy-recovery linear accelerator. The beam was directed successively through
6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a
maximum current of 4.3 mA (430 kW beam power). This study was conducted to
characterize radiation levels for experiments that need to operate in this
environment, such as the proposed DarkLight Experiment. We find that sustained
transmission of a 430 kW continuous-wave (CW) beam through a 2 mm aperture is
feasible with manageable beam-related backgrounds. We also find that during
beam-off, RF-on operation, multipactoring inside the niobium cavities of the
accelerator cryomodules is the primary source of ambient radiation when the
machine is tuned for 130 MeV operation.Comment: 9 pages, 11 figures, submitted to Nuclear Instruments and Methods in
Physics Research Section
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DNA origami protection and molecular interfacing through engineered sequence-defined peptoids
DNA nanotechnology has established approaches for designing programmable and precisely controlled nanoscale architectures through specific WatsonâCrick base-pairing, molecular plasticity, and intermolecular connectivity. In particular, superior control over DNA origami structures could be beneficial for biomedical applications, including biosensing, in vivo imaging, and drug and gene delivery. However, protecting DNA origami structures in complex biological fluids while preserving their structural characteristics remains a major challenge for enabling these applications. Here, we developed a class of structurally well-defined peptoids to protect DNA origamis in ionic and bioactive conditions and systematically explored the effects of peptoid architecture and sequence dependency on DNA origami stability. The applicability of this approach for drug delivery, bioimaging, and cell targeting was also demonstrated. A series of peptoids (PE1â9) with two types of architectures, termed as âbrushâ and âblock,â were built from positively charged monomers and neutral oligo-ethyleneoxy monomers, where certain designs were found to greatly enhance the stability of DNA origami. Through experimental and molecular dynamics studies, we demonstrated the role of sequence-dependent electrostatic interactions of peptoids with the DNA backbone. We showed that octahedral DNA origamis coated with peptoid (PE2) can be used as carriers for anticancer drug and protein, where the peptoid modulated the rate of drug release and prolonged protein stability against proteolytic hydrolysis. Finally, we synthesized two alkyne-modified peptoids (PE8 and PE9), conjugated with fluorophore and antibody, to make stable DNA origamis with imaging and cell-targeting capabilities. Our results demonstrate an approach toward functional and physiologically stable DNA origami for biomedical applications
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