Rosetta: A container-centric science platform for resource-intensive, interactive data analysis

Rosetta is a science platform for resource-intensive, interactive data analysis which runs user tasks as software containers. It is built on top of a novel architecture based on framing user tasks as microservices – independent and self-contained units – which allows to fully support custom and user-defined software packages, libraries and environments. These include complete remote desktop and GUI applications, besides common analysis environments as the Jupyter Notebooks. Rosetta relies on Open Container Initiative containers, which allow for safe, effective and reproducible code execution; can use a number of container engines and runtimes; and seamlessly supports several workload management systems, thus enabling containerized workloads on a wide range of computing resources. Although developed in the astronomy and astrophysics space, Rosetta can virtually support any science and technology domain where resource-intensive, interactive data analysis is required

Drop-out rate among patients treated with omalizumab for severe asthma: Literature review and real-life experience

In patients with asthma, particularly severe asthma, poor adherence to inhaled drugs negatively affects the achievement of disease control. A better adherence rate is expected in the case of injected drugs, such as omalizumab, as they are administered only in a hospital setting. However, adherence to omalizumab has never been systematically investigated. The aim of this study was to review the omalizumab drop-out rate in randomized controlled trials (RCTs) and real-life studies. A comparative analysis was performed between published data and the Italian North East Omalizumab Network (NEONet) database

BeyondPlanck II. CMB map-making through Gibbs sampling

We present a Gibbs sampling solution to the map-making problem for CMB measurements, building on existing destriping methodology. Gibbs sampling breaks the computationally heavy destriping problem into two separate steps; noise filtering and map binning. Considered as two separate steps, both are computationally much cheaper than solving the combined problem. This provides a huge performance benefit as compared to traditional methods, and allows us for the first time to bring the destriping baseline length to a single sample. We apply the Gibbs procedure to simulated Planck 30 GHz data. We find that gaps in the time-ordered data are handled efficiently by filling them with simulated noise as part of the Gibbs process. The Gibbs procedure yields a chain of map samples, from which we may compute the posterior mean as a best-estimate map. The variation in the chain provides information on the correlated residual noise, without need to construct a full noise covariance matrix. However, if only a single maximum-likelihood frequency map estimate is required, we find that traditional conjugate gradient solvers converge much faster than a Gibbs sampler in terms of total number of iterations. The conceptual advantages of the Gibbs sampling approach lies in statistically well-defined error propagation and systematic error correction, and this methodology forms the conceptual basis for the map-making algorithm employed in the BeyondPlanck framework, which implements the first end-to-end Bayesian analysis pipeline for CMB observations.Comment: 11 pages, 10 figures. All BeyondPlanck products and software will be released publicly at http://beyondplanck.science during the online release conference (November 18-20, 2020). Connection details will be made available at the same website. Registration is mandatory for the online tutorial, but optional for the conferenc

BeyondPlanck X. Planck LFI frequency maps with sample-based error propagation

We present Planck LFI frequency sky maps derived within the BeyondPlanck framework. This framework draws samples from a global posterior distribution that includes instrumental, astrophysical and cosmological parameters, and the main product is an entire ensemble of frequency sky map samples. This ensemble allows for computationally convenient end-to-end propagation of low-level instrumental uncertainties into higher-level science products. We show that the two dominant sources of LFI instrumental systematic uncertainties are correlated noise and gain fluctuations, and the products presented here support - for the first time - full Bayesian error propagation for these effects at full angular resolution. We compare our posterior mean maps with traditional frequency maps delivered by the Planck collaboration, and find generally good agreement. The most important quality improvement is due to significantly lower calibration uncertainties in the new processing, as we find a fractional absolute calibration uncertainty at 70 GHz of $\delta g_{0}/g_{0} =5 \cdot 10^{-5}$, which is nominally 40 times smaller than that reported by Planck 2018. However, the original Planck 2018 estimate has a non-trivial statistical interpretation, and this further illustrates the advantage of the new framework in terms of producing self-consistent and well-defined error estimates of all involved quantities without the need of ad hoc uncertainty contributions. We describe how low-resolution data products, including dense pixel-pixel covariance matrices, may be produced directly from the posterior samples without the need for computationally expensive analytic calculations or simulations. We conclude that posterior-based frequency map sampling provides unique capabilities in terms of low-level systematics modelling and error propagation, and may play an important role for future CMB B-mode experiments. (Abridged.)Comment: 32 pages, 23 figures, data available from https://www.cosmoglobe.uio.no

BeyondPlanck XI. Bayesian CMB analysis with sample-based end-to-end error propagation

We present posterior sample-based cosmic microwave background (CMB) constraints from Planck LFI and WMAP observations derived through global end-to-end Bayesian processing. We use these samples to study correlations between CMB, foreground, and instrumental parameters, and we identify a particularly strong degeneracy between CMB temperature fluctuations and free-free emission on intermediate angular scales, which is mitigated through model reduction, masking, and resampling. We compare our posterior-based CMB results with previous Planck products, and find generally good agreement, but with higher noise due to exclusion of HFI data. We find a best-fit CMB dipole amplitude of $3362.7\pm1.4{\mu}K$, in excellent agreement with previous Planck results. The quoted uncertainty is derived directly from the sampled posterior distribution, and does not involve any ad hoc contribution for systematic effects. Similarly, we find a temperature quadrupole amplitude of $\sigma^{TT}_2=229\pm97{\mu}K^2$, in good agreement with previous results in terms of the amplitude, but the uncertainty is an order of magnitude larger than the diagonal Fisher uncertainty. Relatedly, we find lower evidence for a possible alignment between $\ell = 2$ and $\ell = 3$ than previously reported due to a much larger scatter in the individual quadrupole coefficients, caused both by marginalizing over a more complete set of systematic effects, and by our more conservative analysis mask. For higher multipoles, we find that the angular temperature power spectrum is generally in good agreement with both Planck and WMAP. This is the first time the sample-based asymptotically exact Blackwell-Rao estimator has been successfully established for multipoles up to $\ell\le600$, and it now accounts for the majority of the cosmologically important information. Cosmological parameter constraints are presented in a companion paper. (Abriged)Comment: 26 pages, 24 figures. Submitted to A&A. Part of the BeyondPlanck paper suit