A battery-operated, stabilized, high-energy pulsed electron gun for the production of rare gas excimers

We report on the design of a new type of electron gun to be used for experiments of infrared emission spectroscopy of rare gas excimers. It is based on a filament heated by means of a pack of rechargeable batteries floated atop the high-voltage power supply. The filament current is controlled by a feedback circuit including a superluminescent diode decoupled from the high voltage by means of an optical fiber. Our experiment requires that the charge injection is pulsed and constant and stable in time. This electron gun can deliver several tens of nC per pulse of electrons of energy up to $100\,$keV into the sample cell. This new design eliminates ripples in the emission current and ensures up to 12 hrs of stable performance.Comment: 1o pages, 8 figures, to be submitted to Review of Scientific Instrument

"OLD AND LOW-COST SENSOR" FOR MICROPHOTOGRAMMETRY. CASE STUDY: THE EMPEROR <i>MAXIMIANUS HERCULEUS</i>' MEDALLION AT THE CORRER MUSEUM (VENICE)

Abstract. The microphotogrammetric survey of the roman emperor Maximianus Herculeus' medallion, described in this report, demonstrated that, despite the use of an "old" and, nowadays, "low cost" camera sensor it is still possible to obtain a detailed 3D textured model useful for different scientific purposes and virtual enhancement. Here are presented the photogrammetric results reached with the selection of the best solutions in terms of number of images, in order to speed up the entire photogrammetric workflow and pursue the goals previously explained. This medallion is one of the most important examples of roman medallions which belongs to the numismatic collection stored at the Correr Museum in Venice. Its 3D survey was developed as a parallel step of a main project which aims to acquire in three-dimensions, with a structured light scanner, the complete roman collection of medallions. This digitization project proposes to record the volumetric information of these small archaeological remains and to realize an online virtual gallery in the web site of the museum (using 3DHOP, an open source web viewer developed by the Visual Computing Lab of the CNR-ISTI of Pisa). At the end of the microphotogrammetric workflow, a distance analysis was computed to highlight the differences between the meshes obtained with a photogrammetric approach and a structured light scanner

Photometric Studies of a WZ Sge-Type Dwarf Nova Candidate, ASAS160048-4846.2

We report on our time-resolved CCD photometry during the 2005 June superoutburst of a WZ Sge-type dwarf nova candidate, ASAS 160048-4846.2. The ordinary superhumps underwent a complex evolution during the superoutburst. The superhump amplitude experienced a regrowth, and had two peaks. The superhump period decreased when the superhump amplitude reached to the first maximum, successively gradually increased until the second maximum of the amplitude, and finally decreased again. Investigating other SU UMa-type dwarf novae which show an increase of the superhump period, we found the same trend of the superhump evolution in superoutbursts of them. We speculate that the superhump regrowth in the amplitude has a close relation to the increase of the superhump period, and all of SU UMa-type dwarf novae with a superhump regrowth follow the same evolution of the ordinary superhumps as that of ASAS 160048-4846.2.Comment: 7 pages, 4 figure

Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors

Glioblastoma multiforme and medulloblastoma are the most frequent high-grade brain tumors in adults and children, respectively. Standard therapies for these cancers are mainly based on surgical resection, radiotherapy, and chemotherapy. However, intrinsic or acquired resistance to treatment occurs almost invariably in the first case, and side effects are unacceptable in the second. Therefore, the development of new, effective drugs is a very important unmet medical need. A critical requirement for developing such agents is to identify druggable targets required for the proliferation or survival of tumor cells, but not of other cell types. Under this perspective, genes mutated in congenital microcephaly represent interesting candidates. Congenital microcephaly comprises a heterogeneous group of disorders in which brain volume is reduced, in the absence or presence of variable syndromic features. Genetic studies have clarified that most microcephaly genes encode ubiquitous proteins involved in mitosis and in maintenance of genomic stability, but the effects of their inactivation are particularly strong in neural progenitors. It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. Microcephaly genes encode for a few kinases, including CITK, PLK4, AKT3, DYRK1A, and TRIO. In this review, we summarize the evidence indicating that the inhibition of these molecules could exert beneficial effects on different aspects of brain cancer treatment

Discovery of a Promissing Candidate of WZ Sge-Type Dwarf Novae, ASAS 160048-4846.2: Evidence for Double-Peaked Humps

We report on time-resolved CCD photometry during the 2005 June outburst of a dwarf nova, ASAS160048-4846.2. The observed light curves unambiguously showed embryonic humps with a period of 0.063381(41) days, after which genuine superhumps emerged with a period of 0.064927(3) days. Based on evidence for double-peaked humps in the earlier stage of the outburst, this object might be qualified as the seventh member of WZ Sge-type dwarf novae after Var Her 04. If the former period is the same as, or very close to the orbital period of the system, as in other WZ Sge systems, the fractional superhump excess is about 2.4{%}. This value is unexpectedly larger than that of other WZ Sge-type dwarf novae. The early phase of our observing run provided evidence for the transition from chaotic humps to genuine superhumps, together with increasing the amplitude.Comment: 4 pages, 6 figures, submitted to PAS

A modified volumetric energy density–based approach for porosity assessment in additive manufacturing process design

Soundness of additively manufactured parts depends on a lot of process and geometrical parameters. A wrong process design leads to defects such as lack of fusion or keyhole porosity that have a detrimental effect on the mechanical properties of the printed parts. Process parameter optimization is thus a formidable challenge that requires in general a huge amount of experimental data. Among the others, heat source power and scan speed are the most defects-affecting parameters to be optimized. The energy density is used in literature to quantify their combination. Unfortunately, in different works it was demonstrated that it fails if used as design parameter mainly because it does not take into account the material properties and the interaction between heat source and the powder bed. In this contribution, a modified volumetric energy density equation that takes into account the powder-heat source interaction to optimize the combination of power-scan speed values for porosity assessment in powder bed fusion process design is proposed and verified on both AlSi10Mg alloy and Maraging steel 300

Genetic heterogeneity among chicken infectious anemia viruses detected in italian fowl

Chicken infectious anemia virus (CIAV) is a pathogen of chickens associated with immuno-suppression and with a disease named chicken infectious anemia. The present survey reports an epidemiological study on CIAV distribution in Italian broiler, broiler breeder and backyard chicken flocks. Twenty-five strains were detected by a specifically developed nested PCR protocol, and molecularly characterized by partial VP1 gene or complete genome sequencing. Viral DNA ampli-fication was successfully obtained from non-invasive samples such as feathers and environmental dust. Sequence and phylogenetic analysis showed the circulation of field or potentially vaccine-derived strains with heterogeneous sequences clustered into genogroups II, IIIa, and IIIb. Marker genome positions, reported to be correlated with CIAV virulence, were evaluated in field strains. In conclusion, this is the first survey focused on the molecular characteristics of Italian CIAVs, which have proved to be highly heterogeneous, implementing at the same time a distribution map of field viruses worldwide