A battery-operated, stabilized, high-energy pulsed electron gun for the production of rare gas excimers

We report on the design of a new type of electron gun to be used for experiments of infrared emission spectroscopy of rare gas excimers. It is based on a filament heated by means of a pack of rechargeable batteries floated atop the high-voltage power supply. The filament current is controlled by a feedback circuit including a superluminescent diode decoupled from the high voltage by means of an optical fiber. Our experiment requires that the charge injection is pulsed and constant and stable in time. This electron gun can deliver several tens of nC per pulse of electrons of energy up to $100\,$keV into the sample cell. This new design eliminates ripples in the emission current and ensures up to 12 hrs of stable performance.Comment: 1o pages, 8 figures, to be submitted to Review of Scientific Instrument

On the rotation periods of the components of the triple system TYC9300-0891-1AB/TYC9300-0529-1 in the Octans Association

Stellar rotation depends on different parameters. The range of values of these parameters causes the dispersion in the rotation period distributions observed in young stellar clusters/associations. We focus our investigation on the effects of different circumstellar environments on stellar rotation. More specifically, we are searching in stellar Associations for visual triple systems where all stellar parameters are similar, with the only exceptions of the unknown initial rotation period, and of the circum-stellar environment, in the sense that one of the two about equal-mass components has a close-by third 'perturber' component. In the present study we analyse the 35-Myr old visual triple system TYC 9300-0891-1AB + TYC 9300-0529-1 in the young Octans stellar association consisting of three equal-mass K0V components. We collected from the literature all information that allowed us to infer that the three components are actually physically bound forming a triple system and are members of the Octans Association. We collected broad-band photometric timeseries in two observation seasons. We discovered that all the components are variable, magnetically active, and from periodogram analysis we found the unresolved components TYC 9300-0891-1AB to have a rotation period P = 1.383d and TYC 9300-0529-1 a rotation period P = 1.634d. TYC 9300-0891-1A, TYC 9300-0891-1B, and TYC 9300-0529-1 have same masses, ages, and initial chemical compositions. The relatively small 16% rotation period difference measured by us indicates that all components had similar initial rotation periods and disc lifetimes, and the separation of 157AU between the component A and the 'perturber' component B (or vice-versa) has been sufficiently large to prevent any significant perturbation/shortening of the accretion-disc lifetime.Comment: Accepted by New Astronomy 201

Precision Revisited: Targeting Microcephaly Kinases in Brain Tumors

Glioblastoma multiforme and medulloblastoma are the most frequent high-grade brain tumors in adults and children, respectively. Standard therapies for these cancers are mainly based on surgical resection, radiotherapy, and chemotherapy. However, intrinsic or acquired resistance to treatment occurs almost invariably in the first case, and side effects are unacceptable in the second. Therefore, the development of new, effective drugs is a very important unmet medical need. A critical requirement for developing such agents is to identify druggable targets required for the proliferation or survival of tumor cells, but not of other cell types. Under this perspective, genes mutated in congenital microcephaly represent interesting candidates. Congenital microcephaly comprises a heterogeneous group of disorders in which brain volume is reduced, in the absence or presence of variable syndromic features. Genetic studies have clarified that most microcephaly genes encode ubiquitous proteins involved in mitosis and in maintenance of genomic stability, but the effects of their inactivation are particularly strong in neural progenitors. It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. Microcephaly genes encode for a few kinases, including CITK, PLK4, AKT3, DYRK1A, and TRIO. In this review, we summarize the evidence indicating that the inhibition of these molecules could exert beneficial effects on different aspects of brain cancer treatment

Fatigue behavior of hybrid and bonded single lap joints made of composite material

Joining of composite materials can be performed with different techniques and, in particular, trough mechanical fasteners, bonding, hybrid solutions. In last years, hybrid (bolted/bonded) joints are attracting the interest of several companies and scientific community, since the use of both techniques permit to overcome some critical aspects connected to the separate usage of adhesive and bolts, i.e., negative effects of the environmental conditions on adhesive, localized stresses at the notch. This paper aims to improve the knowledge about the fatigue behavior of hybrid CFRP (Carbon Fiber Reinforced Polymer) joints. For the purpose, experimental fatigue and static tests are performed on hybrid and bonded joints and the results herein discussed. Results are post-processed with the main goal to highlight the benefits led to the hybrid technique with respect to the bonding one

Biomolecules responsible for the total antioxidant capacity (Tac) of human plasma in healthy and cardiopathic individuals: A chemical speciation model

(1) Background: Much effort has been expended to investigate the antioxidant capacity of human plasma, attempting to clarify the roles of both metabolic and food substances in determining defenses against oxidative stress. The relationship between the total antioxidant capacity (TAC) and the concentrations of redox-active biomolecules in the human plasma of healthy and cardiopathic individuals was investigated in the present study to develop a chemical speciation model. (2) Methods: Plasma was collected from 85 blood donors and from 25 cardiovascular surgery patients. The TAC was measured using the CUPRAC-BCS (CUPric Reducing Antioxidant Capacity — Bathocuproinedisulfonic acid) method. Biomolecule concentrations were determined via visible spectrophotometry or HPLC/RP techniques. The relationship between the TAC and the concentrations was defined by applying a multiple regression analysis. The significance of the variables was first tested, and chemical models were proposed for the two datasets. The model equation is βTAC=∑iβi·Ai, where βi and [Ai] are the electronic exchange and the molar concentrations of the ith antioxidant component, respectively. (3) Results: The major contributions to the TAC, ~80%, come from endogenous compounds in both healthy and cardiopathic individuals, whereas the contributions from exogenous compounds were different between the two datasets. In particular, γ-tocopherol showed a different role in the chemical models developed for the two groups

Fatigue strength of austempered ductile iron-to-steel dissimilar arc-welded joints

Nowadays, the use of different classes of materials in the same structure is increased to keep pace with innovation and high structural performances. In this context, structural components made of different materials need to be joined together and a possible solution is given by arc welding. Dissimilar welded joints must often be able to withstand fatigue loads; however, Design Standards provide fatigue strength categories only for homogeneous welded joints. The aim of the present paper is to compare the fatigue behaviour of EN-GJS-1050 austempered ductile iron-to-S355J2 steel dissimilar joints to the categories of the corresponding homogeneous steel welded joints, as suggested in International Standards and Recommendations. For this purpose, experimental fatigue tests were performed on a selection of dissimilar welded details. First, the microstructure was identified by metallographic analysis; micro-hardness measurements were collected and residual stress profiles were obtained by using the X-ray diffraction technique on a selection of joints. Misalignments were quantified for all specimens. Then, experimental fatigue tests have been performed on a number of joint geometries subject to axial or bending fatigue loadings and tested in the as-welded conditions. The fracture surfaces of the joints have been analysed to locate fatigue crack nucleation sites