816 research outputs found
Polyvalent Cations Constitute the Voltage Gating Particle in Human Connexin37 Hemichannels
Connexins oligomerize to form intercellular channels that gate in response to voltage and chemical agents such as divalent cations. Historically, these are believed to be two independent processes. Here, data for human connexin37 (hCx37) hemichannels indicate that voltage gating can be explained as block/unblock without the necessity for an independent voltage gate. hCx37 hemichannels closed at negative potentials and opened in a time-dependent fashion at positive potentials. In the absence of polyvalent cations, however, the channels were open at relatively negative potentials, passing current linearly with respect to voltage. Current at negative potentials could be inhibited in a concentration-dependent manner by the addition of polyvalent cations to the bathing solution. Inhibition could be explained as voltage-dependent block of hCx37, with the field acting directly on polyvalent cations, driving them through the pore to an intracellular site. At positive potentials, in the presence of polyvalent cations, the field favored polyvalent efflux from the intracellular blocking site, allowing current flow. The rate of appearance of current depended on the species and valence of the polyvalent cation in the bathing solution. The rate of current decay upon repolarization depended on the concentration of polyvalent cations in the bathing solution, consistent with deactivation by polyvalent block, and was rapid (time constants of tens of milliseconds), implying a high local concentration of polyvalents in or near the channel pore. Sustained depolarization slowed deactivation in a flux-dependent, voltage- and time-independent fashion. The model for hCx37 voltage gating as polyvalent block/unblock can be expanded to account for observations in the literature regarding hCx37 gap junction channel behavior
A Disdrometer based on Ultra-Fast SPAD Cameras
We present a new environmental application of SPAD imagers, namely the continuous and real-time measurement of size and shapes of hydrometeors. Details of the set-up and results obtained with a first 32x32 pixel prototype based on the RADHARD2 chip [1] are illustrated. Real-time operation at very low light levels, 6000 frames per second and 1:100 average data reduction are amongst the most significant achievements
Identity work and the `unemployed' worker: age, disability and the lived experience of the older unemployed
This article seeks to explore how older individuals negotiate and manage their self-identity in relation to work while situated without paid employment. After reviewing the current positions of the older unemployed in the UK, noting the substantial overlap between age and disability, we turn our attention to conceptualizing the lived experiences of individuals through exploring `identity work' as a means of understanding a non-working work identity. Based upon focus group interviews, our empirical analysis focuses on key dimensions of participants' identity practice and how they sought to manage the following social processes: imposed identities; crafting working identities; and contesting unfavourable working identities.The conclusion contextualizes the findings against a backdrop of increasing individualistic discourses underpinning approaches to employability, closes with the policy implications arising from this study, and makes suggestions for future research agendas. </jats:p
Development of a custom on-line ultrasonic vapour analyzer/flowmeter for the ATLAS inner detector, with application to gaseous tracking and Cherenkov detectors
Precision sound velocity measurements can simultaneously determine binary gas
composition and flow. We have developed an analyzer with custom electronics,
currently in use in the ATLAS inner detector, with numerous potential
applications. The instrument has demonstrated ~0.3% mixture precision for
C3F8/C2F6 mixtures and < 10-4 resolution for N2/C3F8 mixtures. Moderate and
high flow versions of the instrument have demonstrated flow resolutions of +/-
2% F.S. for flows up to 250 l.min-1, and +/- 1.9% F.S. for linear flow
velocities up to 15 ms-1; the latter flow approaching that expected in the
vapour return of the thermosiphon fluorocarbon coolant recirculator being built
for the ATLAS silicon tracker.Comment: Paper submitted to TWEPP2012; Topical Workshop on Electronics for
Particle Physics, Oxford, UK, September 17-21, 2012. KEYWORDS: Sonar;
Saturated fluorocarbons; Flowmetry; Sound velocity, Gas mixture analysis. 8
pages, 7 figure
Mechanisms for slow strengthening in granular materials
Several mechanisms cause a granular material to strengthen over time at low
applied stress. The strength is determined from the maximum frictional force
F_max experienced by a shearing plate in contact with wet or dry granular
material after the layer has been at rest for a waiting time \tau. The layer
strength increases roughly logarithmically with \tau -only- if a shear stress
is applied during the waiting time. The mechanisms of strengthening are
investigated by sensitive displacement measurements and by imaging of particle
motion in the shear zone. Granular matter can strengthen due to a slow shift in
the particle arrangement under shear stress. Humidity also leads to
strengthening, but is found not to be its sole cause. In addition to these time
dependent effects, the static friction coefficient can also be increased by
compaction of the granular material under some circumstances, and by cycling of
the applied shear stress.Comment: 21 pages, 11 figures, submitted to Phys. Rev.
Ogbu and the debate on educational achievement: an exploration of the links between education, migration, identity and belonging
This paper looks at some of the issues raised by Ogbuâs work in relation to the education of different minority ethnic groups. Ogbu poses questions such as the value attached to education,
its links to the future and its measurable outcomes in terms of âsuccessâ as experienced by black participants. The desire for better life chances leads families to consider migration to a new country or resettlement within the same country, thus making migration both a local and a global phenomenon. As an example, attention is drawn to the situation facing South Asian
children and their families in the UK. In terms of ethnicity and belonging, the wider question that is significant for many countries in the West after âNine-Elevenâ is the education of Muslim children. A consideration of this current situation throws Ogbuâs identification of âautonomous minorityâ into question. It is argued that a greater understanding of diverse needs has to be
accompanied by a concerted effort to confront racism and intolerance in schools and in society, thus enabling all communities to make a useful contribution and to avoid the âriskâ of failure and disenchantment
Rheology of a confined granular material
We study the rheology of a granular material slowly driven in a confined
geometry. The motion is characterized by a steady sliding with a resistance
force increasing with the driving velocity and the surrounding relative
humidity. For lower driving velocities a transition to stick-slip motion
occurs, exhibiting a blocking enhancement whith decreasing velocity. We propose
a model to explain this behavior pointing out the leading role of friction
properties between the grains and the container's boundary.Comment: 9 pages, 3 .eps figures, submitted to PR
Drug use among British Bangladeshis in London: a macro-structural perspective focusing on disadvantages contributing to individualsâ drug use trajectories and engagement with treatment services
Aims: The main aim of our study was to produce an understanding of factors contributing to drug-using trajectories among men and women from a Bangladeshi background living in East London.
Methods: Fifteen semi-structured, one-to-one interviews were conducted with male and female Bangladeshi drug users accessing treatment services. A macro-structural lens was adopted to interpret participantsâ accounts of their drug use and explored the intersecting factors that at a micro, meso, and macro level impacted on their drug-using trajectories.
Findings: Problem drug use (heroin and crack cocaine) among participants was the result of inter-related factors such as their friendship networks and the embeddedness of drugs in drug-using networks, the structural disadvantages participants experienced, and the need for concealment of their drug use which impacted on participantsâ effective utilisation of drug treatment services. Problem drug use was a functional way of responding to and dealing with social, economic, and cultural disconnection from mainstream institutions as participants faced severe multiple disadvantages engendering stigma and shame.
Conclusions: We propose a âlife-focusedâ intervention aimed at creating extra opportunities and making critically-needed resources available in the marginalised environment of the studyâs participants, which are key to restoring and maintaining agency and sustaining well-being
Are people who participate in cultural activities more satisfied with life?
The influence of various aspects of life on wellbeing has been extensively researched. However, despite little empirical evidence, participation in leisure activities has been assumed to increase subjective wellbeing. Leisure is important because it is more under personal control than other sources of life satisfaction. This study asked whether people who participate in cultural leisure activities have higher life satisfaction than people who do not, if different types of leisure have the same influence on life satisfaction and if satisfaction is dependent on the frequency of participation or the number of activities undertaken. It used data from UKHLS Survey to establish associations between type, number and frequency of participation in leisure activities and life satisfaction. Results showed an independent and positive association of participation in sport, heritage and active-creative leisure activities and life satisfaction but not for participation in popular entertainment, theatre hobbies and museum/galleries. The association of reading hobbies and sedentary-creative activities and life satisfaction was negative. High life satisfaction was associated with engaging in a number of different activities rather than the frequency of participation in each of them. The results have implications for policy makers and leisure services providers, in particular those associated with heritage recreation. Subjective wellbeing measures, such as life satisfaction, and not economic measures alone should be considered in the evaluation of services. The promotion of leisure activities which are active and promote social interaction should be considered in programmes aimed at improving the quality of life
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