The use of structural modelling to infer structure and function in biocontrol agents

Homology modelling can provide important insights into the structures of proteins when a related protein structure has already been solved. However, for many proteins, including a number of invertebrate-active toxins and accessory proteins, no such templates exist. In these cases, techniques of ab initio, template-independent modelling can be employed to generate models that may give insight into structure and function. In this overview, examples of both the problems and the potential benefits of ab initio techniques are illustrated. Consistent modelling results may indicate useful approximations to actual protein structures and can thus allow the generation of hypotheses regarding activity that can be tested experimentally

A History of New Orleans at Year 300

Jason Berry in conversation with Curtis Wilki

Business leadership and management development - A continual educational approach

Develop leadership and management skills for business success

Effectiveness of a Federal Healthy Start Program in Reducing Infant Mortality

Objective: Infant mortality is an important indicator of the health status of a community. In this analysis, we aimed to evaluate temporal changes in infant mortality rates (IMR) in the Central Hillsborough Healthy Start (CHHS) program service area in Tampa, Florida compared to rates in the rest of Hillsborough County and the state. Method: We conducted a five-year (2010-2014) trends analysis using birth and infant death data extracted from the Florida Community Health Assessment Resource Tool Set (CHARTS). The number of infant deaths and live births were used to calculate and compare IMRs in the CHHS catchment area to those in the rest of Hillsborough County, and the state of Florida. Three-year centered moving averages were directly adjusted to account for differences in the racial/ethnic distribution of mothers across geographic areas. Results: Between 2010 and 2014, the IMR decreased 42.8% in the CHHS service area (from 14.5 to 8.3 per 1,000 live births) compared to decreases of 10.1% and 7.7% in the rest of Hillsborough County and the state of Florida, respectively. Additionally, the infant mortality gap in the CHHS catchment area narrowed from 72% in 2010 to 14% in 2014 compared to the rest of the state, and was eliminated when compared to the rest of Hillsborough County. Discussion: The absolute and relative decreases in IMR in the CHHS catchment area reflect the program’s effectiveness in decreasing disparity in infant mortality. The quality services provided by the CHHS program have had a significant positive impact on the families served

Molecular biology of amitraz resistance in cattle ticks of the genus Rhipicephalus

Amitraz is an important product for the control of cattle ticks around the world. In comparison with other products for the control of ticks, it is quite affordable and it has a rapid knock-down effect. It binds with and activates adrenergic neuro-receptors of animals and it inhibits the action of monoamine oxidases (MAO). Resistance to amitraz has been documented in Rhipicephalus microplus, R. decoloratus and R. appendiculatus. Four mechanisms of resistance have been proposed, each of which is supported by evidence but none of which has been definitively confirmed as the cause of resistance in the field. The proposed mechanisms include genetic target site insensitivity in two G protein-coupled receptors, the beta-adrenergic octopamine receptor (BAOR) and the octopamine/tyramine receptor (OCT/Tyr), increased expression or activity of monoamine oxidases and increased expression or activity of the ATP binding cassette transporter

Exploration of the perceptual-cognitive processes that contribute to in-game decision-making of Australian football umpires

Decision-making is fundamental to officiating in all sports. It is well established in contemporary research that decision-making skills underpin umpire expertise; however, there is little understanding of the cognitive processes that contribute to in-game decision-making. This research implemented an in-depth case study approach, using qualitative methods, to explore the in-game decision-making process of three Australian football umpires. Concurrent and retrospective verbalisation methods were used to obtain verbal reports of the cognitive processes associated with decision-making. Findings identified three salient themes related to both in-game decision-making processes (i.e. decision evaluation, player intention during game-play) and umpire performance (i.e. knowledge of game-play). These themes contributed to the development of decision-making heuristics for Australian football umpires. This study provides initial evidence of the factors that may contribute to and/or affect in-game decision-making processes; however, additional exploration is necessary to further inform training programmes aimed to develop domain-specific decision-making skills and subsequent in-game performance. © 2016 International Society of Sport Psychology

Symmetries of Cairo-Prismatic Tilings

We study and catalog isoperimetric, planar tilings by unit-area Cairo and Prismatic pentagons. In particular, in counterpoint to the five wallpaper symmetry groups known to occur in Cairo-Prismatic tilings, we show that the five with order three rotational symmetry cannot occur