Compact gain-saturated x-ray lasers down to 6.85 nm and amplification down to 5.85 nm

Includes bibliographical references (pages 261-262).Plasma-based x-ray lasers allow single-shot nano-scale imaging and other experiments requiring a large number of photons per pulse to be conducted in compact facilities. However, compact repetitively fired gain-saturated x-ray lasers have been limited to wavelengths above λ = 8.85 nm. Here we extend their range to λ = 6.85 nm by transient traveling wave excitation of Ni-like Gd ions in a plasma created with an optimized pre-pulse followed by rapid heating with an intense sub-picosecond pump pulse. Isoelectronic scaling also produced strong lasing at 6.67 nm and 6.11 nm in Ni-like Tb and amplification at 6.41 nm and 5.85 nm in Ni-like Dy. This scaling to shorter wavelengths was obtained by progressively increasing the pump pulse grazing incidence angle to access increased plasma densities. We experimentally demonstrate that the optimum grazing incidence angle increases linearly with atomic number from 17 deg for Z = 42 (Mo) to 43 deg for Z = 66 (Dy). The results will enable applications of sub-7 nm lasers at compact facilities

Improved Copper Circularity as a Result of Increased Material Efficiency in the U.S. Housing Stock

Material efficiency (ME) can support rapid climate change mitigation and circular economy. Here, we comprehensively assess the circularity of ME strategies for copper use in the U.S. housing services (including residential buildings and major household appliances) by integrating use-phase material and energy demand. Although the ME strategies of more intensive floor space use and extended lifetime of appliances and buildings reduce the primary copper demand, employing these strategies increases the commonly neglected use-phase share of total copper requirements during the century from 23–28 to 22–42%. Use-phase copper requirements for home improvements have remained larger than the demand gap (copper demand minus scrap availability) for much of the century, limiting copper circularity in the U.S. housing services. Further, use-phase energy consumption can negate the benefits of ME strategies. For instance, the lifetime extension of lower-efficiency refrigerators increases the copper use and net environmental impact by increased electricity use despite reductions from less production. This suggests a need for more attention to the use phase when assessing circularity, especially for products that are material and energy intensive during use. To avoid burden shifting, policymakers should consider the entire life cycle of products supporting services when pursuing circular economy goals

Saturated high-repetition-rate 18.9-nm tabletop laser in nickel-like molybdenum

Includes bibliographical references (page 167).We report saturated operation of an 18.9-nm laser at 5-Hz repetition rate. An amplification with a gain-length product GL of 15.5 is obtained in the 4d 1S0―4p 1P1 laser line of Ni-like Mo in plasmas heated at grazing incidence with ~1-J pulses of 8.1-ps duration from a tabletop laser system. Lasing is obtained over a broad range of time delays and pumping conditions. We also measure a GL of 13.5 in the 22.6-nm transition of the same ion. The results are of interest for numerous applications requiring high-repetition-rate lasers at wavelengths below 20 nm

The risk of oesophago-gastric cancer in symptomatic patients in primary care: A large case-control study using electronic records

BACKGROUND: Over 15 000 new oesophago-gastric cancers are diagnosed annually in the United Kingdom, with most being advanced disease. We identified and quantified features of this cancer in primary care. METHODS: Case-control study using electronic primary-care records of the UK patients aged ≥40 years was performed. Cases with primary oesophago-gastric cancer were matched to controls on age, sex and practice. Putative features of cancer were identified in the year before diagnosis. Odds ratios (ORs) were calculated for these features using conditional logistic regression, and positive predictive values (PPVs) were calculated. RESULTS: A total of 7471 cases and 32 877 controls were studied. Sixteen features were independently associated with oesophago-gastric cancer (all P5% in patients ≥55 years was for dysphagia. In patients <55 years, all PPVs were <1%. CONCLUSION: Symptoms of oesophago-gastric cancer reported in secondary care were also important in primary care. The results should inform guidance and commissioning policy for upper GI endoscopy

Natural Variation of Model Mutant Phenotypes in Ciona intestinalis

BACKGROUND: The study of ascidians (Chordata, Tunicata) has made a considerable contribution to our understanding of the origin and evolution of basal chordates. To provide further information to support forward genetics in Ciona intestinalis, we used a combination of natural variation and neutral population genetics as an approach for the systematic identification of new mutations. In addition to the significance of developmental variation for phenotype-driven studies, this approach can encompass important implications in evolutionary and population biology. METHODOLOGY/PRINCIPAL FINDINGS: Here, we report a preliminary survey for naturally occurring mutations in three geographically interconnected populations of C. intestinalis. The influence of historical, geographical and environmental factors on the distribution of abnormal phenotypes was assessed by means of 12 microsatellites. We identified 37 possible mutant loci with stereotyped defects in embryonic development that segregate in a way typical of recessive alleles. Local populations were found to differ in genetic organization and frequency distribution of phenotypic classes. CONCLUSIONS/SIGNIFICANCE: Natural genetic polymorphism of C. intestinalis constitutes a valuable source of phenotypes for studying embryonic development in ascidians. Correlating genetic structure and the occurrence of abnormal phenotypes is a crucial focus for understanding the selective forces that shape natural finite populations, and may provide insights of great importance into the evolutionary mechanisms that generate animal diversity

STAGES IN THE ORIGIN OF VERTEBRATES: ANALYSIS BY MEANS OF SCENARIOS

Vertebrates lack an epidermal nerve plexus. This feature is common to many invertebrates from which vertebrates differ by an extensive set of shared-derived characters (synapomorphies) derived from the neural crest and epidermal neurogenic placodes. Hence, the hypothesis that the developmental precursor of the epidermal nerve plexus may be homologous to the neural crest and epidermal neurogenic placodes. This account attempts to generate a nested set of scenarios for the prevertebrate-vertebrate transition, associating a presumed sequence of behavioural and environmental changes with the observed phenotypic ones. Toward this end, it integrates morphological, developmental, functional (physiological/behavioural) and some ecological data, as many phenotypic shifts apparently involved associated transitions in several aspects of the animals. The scenarios deal with the origin of embryonic and adult tissues and such major organs as the notochord, the CNS, gills and kidneys and propose a sequence of associated changes. Alternative scenarios are stated as the evidence often remains insufficient for decision. The analysis points to gaps in comprehension of the biology of the animals and therefore suggests further research.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72629/1/j.1469-185X.1989.tb00471.x.pd

Interspecific Hybridization and Mitochondrial Introgression in Invasive Carcinus Shore Crabs

Interspecific hybridization plays an important role in facilitating adaptive evolutionary change. More specifically, recent studies have demonstrated that hybridization may dramatically influence the establishment, spread, and impact of invasive populations. In Japan, previous genetic evidence for the presence of two non-native congeners, the European green crab Carcinus maenas and the Mediterranean green crab C. aestuarii, has raised questions regarding the possibility of hybridization between these sister species. Here I present analysis based on both nuclear microsatellites and the mitochondrial cytochrome C oxidase subunit I (COI) gene which unambiguously argues for a hybrid origin of Japanese Carcinus. Despite the presence of mitochondrial lineages derived from both C. maenas and C. aestuarii, the Japanese population is panmictic at nuclear loci and has achieved cytonuclear equilibrium throughout the sampled range in Japan. Furthermore, analysis of admixture at nuclear loci indicates dramatic introgression of the C. maenas mitochondrial genome into a predominantly C. aestuarii nuclear background. These patterns, along with inferences drawn from the observational record, argue for a hybridization event pre-dating the arrival of Carcinus in Japan. The clarification of both invasion history and evolutionary history afforded by genetic analysis provides information that may be critically important to future studies aimed at assessing risks posed by invasive Carcinus populations to Japan and the surrounding region