102 research outputs found
A program for optical observations of advanced LIGO early triggers in the southern hemisphere
In this poster we present a plan to follow-up optically early triggers from the Advanced LIGO gravitational wave detectors, which will start operating in scientific mode in the northern summer of 2015
Molecular subtypes of breast cancer: prognostic implications and clinical and immunohistochemical characteristics
Fundamento. Los carcinomas de mama representan un grupo
heterogéneo de tumores, tanto en su comportamiento clínico
como pronóstico. El objetivo del presente trabajo es clasificar
los carcinomas de mama en subtipos moleculares mediante
marcadores inmunohistoquímicos y analizar las características
clinicopatológicas e inmunohistoquímicas y los patrones
de supervivencia y recaída de los distintos subtipos.
Material y métodos. Se han clasificado 272 pacientes con
diagnóstico de carcinoma de mama en cinco subtipos: carcinomas
de mama de tipo basal, de tipo HER2, de tipo luminal
A, de tipo luminal B y normal.
Resultados. Los carcinomas de mama más frecuentes fueron
los de tipo luminal A (62,5%), carcinomas de tipo luminal B
(18%), carcinomas de tipo HER2 (9,9%), carcinomas de tipo
basal (8,4%) y los de fenotipo normal (1,4%). Los carcinomas
de mama de tipo luminal mostraron ser, con mayor frecuencia,
de forma significativa, tumores bien diferenciados, de
pequeño tamaño tumoral, con ganglios axilares negativos,
estadio precoz en el momento del diagnóstico, niveles altos
de BCL-2 y bajo índice de proliferación con Ki-67. En cambio,
los carcinomas de mama de tipo basal y HER2 presentaban
tumores de mayor tamaño, pobremente diferenciados, mayor
compromiso ganglionar y estadios más avanzados en el
momento del diagnóstico. Expresaban con mayor frecuencia
índices de proliferación altos con Ki 67 y fueron los subtipos
que en curvas de supervivencia global y de supervivencia libre
de progresión mostraron un peor pronóstico.
Conclusión. La clasificación del cáncer de mama basada en
parámetros inmunohistoquímicos (IHQ) permite una mejor
definición pronóstica. Tanto los carcinomas de mama de
tipo basal como HER2 presentan características histopatológicas
e IHQ más desfavorables así como peor supervivencia
y menor tiempo de recaída mientras que los carcinomas
de mama de tipo luminal manifiestan características más
benignas y mejor pronóstico.Background. Breast carcinomas are a heterogeneous group
of tumours, in both their clinical behavior and their prognosis.
The aim of this article is to classify breast carcinomas
according to molecular subtypes by means of immunohistochemical
markers and to analyse the clinicopathological
and immunohistochemical characteristics and the patterns
of survival and relapse of the different subtypes.
Methods. Two hundred and seventy-two patients diagnosed
with breast cancer were classified into five subtypes: breast
carcinomas of the basal type, HER2 type, luminal A type,
luminal B type and normal.
Results. The most frequent breast carcinomas were: luminal
A type carcinomas (62.5%), luminal B type carcinomas
(18%), HER2 type carcinomas (9.9%), basal type carcinomas
(8.4%) and normal phenotype carcinomas (1.4%). Significantly
and with greater frequency, the luminal type breast
carcinomas proved to be well differentiated tumours, of
small tumoral size, with negative axillary lymph nodes, at an
early stage at the time of diagnosis, with high levels of BCL-
2 and a low Ki-67 proliferation index. On the contrary, the
basal type and HER2 carcinomas presented larger tumours,
poorly differentiated, greater ganglionar involvement and
more advanced stages at the time of diagnosis. They expressed
high Ki-67 proliferation indexes with greater frequency
and were the subtypes that showed a worse prognosis on
global survival and progression-free survival curves.
Conclusion. Breast cancer classification based on immunohistochemical
(IHC) parameters makes a better prognostic
definition possible. Both the basal type and the HER2 type
breast carcinomas present more unfavourable histopathological
and IHC characteristics, as well as a worse survival
and less relapse time, while the luminal type breast carcinomas
show more benign characteristics and a better prognosis
Perturbations of Gauss-Bonnet Black Strings in Codimension-2 Braneworlds
We derive the Lichnerowicz equation in the presence of the Gauss-Bonnet term.
Using the modified Lichnerowicz equation we study the metric perturbations of
Gauss-Bonnet black strings in Codimension-2 Braneworlds.Comment: 26 pages, no figures, clarifying comments and one reference added, to
be published in JHE
Multiple mutations in the nicotinic acetylcholine receptor Ccα6 gene associated with resistance to spinosad in medfly
Spinosad is an insecticide widely used for the control of insect pest species, including Mediterranean fruit fly, Ceratitis capitata. Its target site is the α6 subunit of the nicotinic acetylcholine receptors, and different mutations in this subunit confer resistance to spinosad in diverse insect species. The insect α6 gene contains 12 exons, with mutually exclusive versions of exons 3 (3a, 3b) and 8 (8a, 8b, 8c). We report here the selection of a medfly strain highly resistant to spinosad, JW-100 s, and we identify three recessive Ccα6 mutant alleles in the JW-100 s population: (i) Ccα63aQ68* containing a point mutation that generates a premature stop codon on exon 3a (3aQ68*); (ii) Ccα63aAG>AT containing a point mutation in the 5' splicing site of exon 3a (3aAG > AT); and (iii) Ccα63aQ68*-K352* that contains the mutation 3aQ68* and another point mutation on exon 10 (K352*). Though our analysis of the susceptibility to spinosad in field populations indicates that resistance has not yet evolved, a better understanding of the mechanism of action of spinosad is essential to implement sustainable management practices to avoid the development of resistance in field populations
- …