Retrospective-Cost-Based Adaptive Input and State Estimation for the Ionosphere–Thermosphere

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140666/1/1.I010286.pd

Retrospective Cost Optimization for Adaptive State Estimation, Input Estimation, and Model Refinement

AbstractRetrospective cost optimization was originally developed for adaptive control. In this paper, we show how this technique is applicable to three distinct but related problems, namely, state estimation, input estimation, and model refinement. To illustrate these techniques, we give two examples. In the first example, retrospective cost model refinement is used with synthetic data to estimate the cooling dynamics that are missing from a model of the ionosphere-thermosphere. In the second example, retrospective cost adaptive state estimation is used with data from a satellite to estimate a solar driver in the ionosphere- thermosphere, with performance gauged by using data from a second satellite

Structural and molecular interrogation of intact biological systems

Obtaining high-resolution information from a complex system, while maintaining the global perspective needed to understand system function, represents a key challenge in biology. Here we address this challenge with a method (termed CLARITY) for the transformation of intact tissue into a nanoporous hydrogel-hybridized form (crosslinked to a three-dimensional network of hydrophilic polymers) that is fully assembled but optically transparent and macromolecule-permeable. Using mouse brains, we show intact-tissue imaging of long-range projections, local circuit wiring, cellular relationships, subcellular structures, protein complexes, nucleic acids and neurotransmitters. CLARITY also enables intact-tissue in situ hybridization, immunohistochemistry with multiple rounds of staining and de-staining in non-sectioned tissue, and antibody labelling throughout the intact adult mouse brain. Finally, we show that CLARITY enables fine structural analysis of clinical samples, including non-sectioned human tissue from a neuropsychiatric-disease setting, establishing a path for the transmutation of human tissue into a stable, intact and accessible form suitable for probing structural and molecular underpinnings of physiological function and disease

Global model comparison with Millstone Hill during September 2005

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95551/1/jgra18878.pd

The Impact of Inpatient Boarding on ED Efficiency: A Discrete-Event Simulation Study

In this study, a discrete-event simulation approach was used to model Emergency Department’s (ED) patient flow to investigate the effect of inpatient boarding on the ED efficiency in terms of the National Emergency Department Crowding Scale (NEDOCS) score and the rate of patients who leave without being seen (LWBS). The decision variable in this model was the boarder-released-ratio defined as the ratio of admitted patients whose boarding time is zero to all admitted patients. Our analysis shows that the Overcrowded+ (a NEDOCS score over 100) ratio decreased from 88.4% to 50.4%, and the rate of LWBS patients decreased from 10.8% to 8.4% when the boarder-released-ratio changed from 0% to 100%. These results show that inpatient boarding significantly impacts both the NEDOCS score and the rate of LWBS patient and this analysis provides a quantification of the impact of boarding on emergency department patient crowding

The impact of camera optical alignments on weak lensing measures for the Dark Energy Survey

Telescope Point Spread Function (PSF) quality is critical for realising the potential of cosmic weak lensing observations to constrain dark energy and test General Relativity. In this paper we use quantitative weak gravitational lensing measures to inform the precision of lens optical alignment, with specific reference to the Dark Energy Survey (DES). We compute optics spot diagrams and calculate the shear and flexion of the PSF as a function of position on the focal plane. For perfect optical alignment we verify the high quality of the DES optical design, finding a maximum PSF contribution to the weak lensing shear of 0.04 near the edge of the focal plane. However this can be increased by a factor of approximately three if the lenses are only just aligned within their maximum specified tolerances. We calculate the E and B-mode shear and flexion variance as a function of de-centre or tilt of each lens in turn. We find tilt accuracy to be a few times more important than de-centre, depending on the lens considered. Finally we consider the compound effect of de-centre and tilt of multiple lenses simultaneously, by sampling from a plausible range of values of each parameter. We find that the compound effect can be around twice as detrimental as when considering any one lens alone. Furthermore, this combined effect changes the conclusions about which lens is most important to align accurately. For DES, the tilt of the first two lenses is the most important.Comment: 10 pages, 8 figure