Neuropsychiatric phenotype of post COVID-19 syndrome in non-hospitalized patients

The post COVID-19 syndrome (PCS) is an emerging phenomenon worldwide with enormous socioeconomic impact. While many patients describe neuropsychiatric deficits, the symptoms are yet to be assessed and defined systematically. In this prospective cohort study, we report on the results of a neuropsychiatric consultation implemented in May 2021. A cohort of 105 consecutive patients with merely mild acute course of disease was identified by its high symptom load 6 months post infection using a standardized neurocognitive and psychiatric-psychosomatic assessment. In this cohort, we found a strong correlation between higher scores in questionnaires for fatigue (MFI-20), somatization (PHQ15) and depression (PHQ9) and worse functional outcome as measured by the post COVID functional scale (PCFS). In contrast, neurocognitive scales correlated with age, but not with PCFS. Standard laboratory and cardiopulmonary biomarkers did not differ between the group of patients with predominant neuropsychiatric symptoms and a control group of neuropsychiatrically unaffected PCS patients. Our study delineates a phenotype of PCS dominated by symptoms of fatigue, somatisation and depression. The strong association of psychiatric and psychosomatic symptoms with the PCFS warrants a systematic evaluation of psychosocial side effects of the pandemic itself and psychiatric comorbidities on the long-term outcome of patients with SARS-CoV-2 infection

Object alternation in alcohol dependent patients without amnesic syndrome

Item does not contain fulltextSeveral studies indicate that the frontal cortex is sensitive to the toxic effects of alcohol. Recent studies of our group revealed all impairment of alcohol dependent subjects in object alternation. One major problem of these studies is that they all used object alternation embedded in a spatial presentation and with two spatially arranged response buttons: a left and a right hand response key. The deficit in alternation tasks may be due to problems in processing these spatial features. We investigated 24 detoxified alcohol dependent patients, who were in a long term treatment program, and 28 control subjects matched for intelligence and age. using a new object alternation paradigm avoiding confounding of spatial effects. The results indicate that object alternation is impaired in long term alcohol dependent patients without amnesic syndrome, even when no differential spatial response is afforded. We suggest that internal control on a cognitive level, as well as oil a behavioral level, may be a fundamental problem in addiction and might be related to ventromedial and orbitofrontal dysfunction.8 p

A Companion to Greek and Latin Pastoral

SI PRECISA CHE IL VOLUME "Brill's companion to Greek and Latin pastoral" E' STATO EDITO DA ME E DAL COLLEGA PAPANGHELIS, E CONTIENE, OLTRE A UN MIO PERSONALE CONTRIBUTO, CIRCA UNA VENINA DI ARTICOLI DI ALTRI STUDIOSI. IL MIO PERSONALE CONTRIBUTO AD ESSO E' STATO ALTROVE INDICATO COME "CAPITOLO DI LIBRO". IL MIO RUOLO NEI RIGUARDI DELLA TOTALITA' DEL VOLUME (pp. 1-654) E' STATO INVECE SOLO QUELLO DI CURATORE (IN COLLABORAZIONE CON PAPANGHELIS