BIOMASS PRODUCTION AS AN ENERGY SOURCE IN COPPICES OF THE PROVINCE OF FLORENCE, ITALY: CONSIDERING THE ECONOMIC AND EMPLOYMENT ASPECTS

Coppice management of forests in Tuscany, and particularly in the province of Florence, has had a chequered history, which has set the stage for the present problems of forestry policy. In Italy, the period between 1955 and 1975 saw a marked reduction in use of firewood in the home and its virtual elimination from the industrial context, leading to progressive abandonment of coppice management. Since 1975, wood-cutting has once again become an increasingly frequent practice, mainly in beech and deciduous oak forests, to the point that this phenomenon has been defined as a veritable revival of coppice management. This change is due partly to a rise in firewood prices but also to the greater yield obtainable from processing activities, although the observed increase is to be attributed not so much to technological progress (only a few enterprises have adequate equipment), as to the mass accumulated during the period of non-harvesting. Basing our opinion on these considerations we realized a project for assessing the "actual" economic, occupational and environmental potential of coppice management in the province of Florence for biomass production as an energy source. To this end, our work has tried to identify the new potential market area, the enterprises typology, and analyse the social and environmental impact. Moreover, we have evaluated economic efficiency and have taken into consideration the public intervention needed to develop new markets. We have seen that at the moment the possible market areas are tied not only to the traditional markets for house heating by traditional stove with low performance, but also to a new market tied to the most recent developments in heating technologies for dwelling places and small environments, that have allowed considerable technological improvement in heating systems using wood biomasses, which are now more economical and easier to use, have lower gas emission levels and offer greater safety. Another potential market is tied to the electric power production, through the transformation from energy produced by combustion of wood biomass into electric power energy, that we can use in times of peak power consumption in the area studied. The results of this study shows that use of wood biomasses in the energy sector is competitive with oil and gas fired systems, and that biomass production as an energy source is not only environmentally sustainable but also economically feasible and capable of creating job opportunities. Moreover, the possibility for development of two new market areas exists: the first is tied to production of heating energy with new technology plants that use a wood biomass, and result in a high performance; the second is the possibility to develop the electric energy market with the use of gasification or cogeneration plants. In both cases it is possible to create new activities for installation, maintenance and fueling of heating plants, for maintenance and fueling electric generator plants, which will be complementary to harvesting activityResource /Energy Economics and Policy,

Comment on “early efficacy of intra-articular HYADD® 4 (Hymovis®) injections for symptomatic knee osteoarthritis”

We read with great interest the study by Priano titled“Early efficacy of intra-articular HYADD® 4 (Hymovis®) injections for symptomatic knee osteoarthritis.” 1 The author would like to explore the efficacy of intra-articular HYADD 4 (Hymovis) injections for symptomatic knee osteoarthritis. Results from this study are very interesting and promising from a clinical aspect; however, we believe that studying patient’sclinical status with visual analog scale and Western Ontario and McMaster Universities Arthritis Index scale should be supported by biomechanical information. From this point of view, to have more data that could influence the clinical practice, it is important to note the possible action that intraarticular injections of different kinds of hyaluronic acid could have on walking biomechanics using an objective measurement tool as gait analysis. In our opinion, the work by Priano1 is promising because it investigates the efficacy of a new formulation of hyaluronic acid. Nowadays, many hyaluronic acid formulations are approved for clinical use in Europe and the United States. Furthermore, hyaluronic acid injections’ efficacy has been demonstrated also in hip osteoarthritis. 2 However, even if these formulations differ in their chemical– physical properties, joint space half-life, rheological properties, and clinical efficacy, there are few studies that investigate hyaluronic acid’s possible action from a biomechanical point of view. 3,4 From this point of view, we believe that osteoarthritis management and rehabilitation should be prescribed after an objective analysis of functional walking alterations using gait analysis instrumentations. The use of gait analysis should be desirable during diagnosis and follow-up. In fact, it is capable to identify different walking patterns in patient with osteoarthritis of the lower limbs, whereas the radiology can evaluate the status of the joint’s structures

Impact of COVID-19 outbreak on rehabilitation services and Physical and Rehabilitation Medicine physicians' activities in Italy An official document of the Italian PRM Society (SIMFER)

Since the onset of the COVID-19 outbreak in Europe, Italy has been among the first affected countries, and the number of reported cases is still the highest in the continent. Since the beginning, the epidemic has had a huge impact in the acute sector of the healthcare system (especially the emergency departments, Intensive Care Units (ICUs), laboratory and imaging services), and these services have been experiencing increasing pressur

Refinement of molecular dynamics ensembles using experimental data and flexible forward models

A novel method combining maximum entropy principle, the Bayesian-inference of ensembles approach, and the optimization of empirical forward models is presented. Here we focus on the Karplus parameters for RNA systems, which relate the dihedral angles of $\gamma$, $\beta$, and the dihedrals in the sugar ring to the corresponding $^3J$-coupling signal between coupling protons. Extensive molecular simulations are performed on a set of RNA tetramers and hexamers and combined with available nucleic-magnetic-resonance data. Within the new framework, the sampled structural dynamics can be reweighted to match experimental data while the error arising from inaccuracies in the forward models can be corrected simultaneously and consequently does not leak into the reweighted ensemble. Carefully crafted cross-validation procedure and regularization terms enable obtaining transferable Karplus parameters. Our approach identifies the optimal regularization strength and new sets of Karplus parameters balancing good agreement between simulations and experiments with minimal changes to the original ensemble.Comment: Submitted to journal; added zenodo link; replaced fig. 3 with correct on

Uncertainty assessment in climate change scenarios: a methodological proposal for management of forest ecosystem services

The work introduces a method to quantify potential impact of climate change on cultural ecosystem services in forests. The technique of Hesitant Fuzzy Linguistic Term Set is applied to face with the uncertainty due to climate change as well as subjective opinion of forest experts. Two forest management scenario (current practices as well as climate change-oriented silviculture) are investigated for different time horizons. Results highlight the increasing uncertainty on climate change impact evaluation related to longer time horizons. Potential losses connected to current cultural ecosystem services provision are quantified from spatial as well as economic viewpoint. The method is tested for an illustrative example in the Tuscany region - central Italy

Molecular dynamics simulations of chemically modified ribonucleotides

Post-transcriptional modifications are crucial for RNA function, with roles ranging from the stabilization of functional RNA structures to modulation of RNA--protein interactions. Additionally, artificially modified RNAs have been suggested as optimal oligonucleotides for therapeutic purposes. The impact of chemical modifications on secondary structure has been rationalized for some of the most common modifications. However, the characterization of how the modifications affect the three-dimensional RNA structure and dynamics and its capability to bind proteins is still highly challenging. Molecular dynamics simulations, coupled with enhanced sampling methods and integration of experimental data, provide a direct access to RNA structural dynamics. In the context of RNA chemical modifications, alchemical simulations where a wild type nucleotide is converted to a modified one are particularly common. In this Chapter, we review recent molecular dynamics studies of modified ribonucleotides. We discuss the technical aspects of the reviewed works, including the employed force fields, enhanced sampling methods, and alchemical methods, in a way that is accessible to experimentalists. Finally, we provide our perspective on this quickly growing field of research. The goal of this Chapter is to provide a guide for experimentalists to understand molecular dynamics works and, at the same time, give to molecular dynamics experts a solid review of published articles that will be a useful starting point for new research.Comment: Submitted as a chapter for the book "RNA Structure and Function", series "RNA Technologies", published by Springe

Strumenti metodologici per la gestione del paesaggio nella pianificazione territoriale

Strumenti metodologici per la gestione del paesaggio nella pianificazione territorial