trial registration_part 2_061111

dataset of RCTs published in journals mentioning and requiring or not mentioning trial registration in their author instruction

Results_trial registration_part 1_061111

results of endorsement of trial registration in journal author instructions in relevant urology journal

AnalyseTrialRegistration

statistical code for endorsement of trial registration in journal author instructions in relevant urology journal

Effect of Cecropin B on cell membranes of 486P bladder cancer cells and ZF07 fibroblasts as visualized by scanning electron microscopy (SEM)

Representative example of an untreated 486P bladder cancer cell showing a smooth surface. 486P cells treated with 65 μM Cecropin B reveal a disrupted cell membrane with only small islands of intact surface left (arrow). In contrast, untreated ZF07 fibroblasts and () fibroblasts after incubation with 65 μM Cecropin B do not display any changes in cell morphology with no observable damage to the cell membrane.<p><b>Copyright information:</b></p><p>Taken from "Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells"</p><p>http://www.biomedcentral.com/1471-2490/8/5</p><p>BMC Urology 2008;8():5-5.</p><p>Published online 3 Mar 2008</p><p>PMCID:PMC2276511.</p><p></p

Overview of detected chromosomal aberrations by cCGH and aCGH

<p>Overview of detected chromosomal aberrations by cCGH and aCGH</p

GnRH antagonist versus standard AST

RevMan data file of data analysis/meta-analysis. For details on patient characteristics, characteristics of included studies, risk of bias assessment and evaluation of quality of evidence according to GRADE see published manuscript (BMJ Open

Validation of amplicons by FISH analysis on cell lines.

<p>Identification of increased copies of signals of the BAC clone RP11-165H19 mapped to 9p13.3 amplicon in cell line CWR22 and CWR22-Rv1 (A and B). C Optimal signal and lack of cross hybridization was verified using normal metaphase spreads showing two signals for each probe. BAC clone RP11-165H19 signals are green; red signals indicate chromosome 9 centromere (D9Z1).</p

Comparison of cCGH (A, C) and arrayCGH (B, D) results from chromosome 9 of CWR22 and chromosome 14 of DU145-MN1.

<p>A small region of gain on 9p close to the centromer (B, arrowhead) and a small deletion on 14q (D, arrowhead) are only detected by arrayCGH.</p

Heatmap and cluster dendrogram demonstrating the expression patterns of the seven analyzed markers in UTUC.

<p>Using hierarchical clustering the tumor samples could be classified into four groups based on expression of the markers: A basal-like subtype with high expression levels of CK5, CD44 and, to a lesser extent, EGFR (green cluster); a luminal-like subtype with high expression levels of CK20, GATA3 and FOXA1 (red cluster); a subtype with expression of both luminal and basal-type markers (blue cluster); a subtype without significant expression of any markers (black cluster).</p

Distribution of clones according to the AUC values that were determined for the classification of PCa vs. Normal, BPH vs. Normal, PCa vs. BPH, and PCa (PSA>4.0) vs. BPH (PSA>4.0).

<p>Distribution of clones according to the AUC values that were determined for the classification of PCa vs. Normal, BPH vs. Normal, PCa vs. BPH, and PCa (PSA>4.0) vs. BPH (PSA>4.0).</p