2 research outputs found
Second-Coordination-Sphere Effects Increase the Catalytic Efficiency of an Extended Model for Fe<sup>III</sup>M<sup>II</sup> Purple Acid Phosphatases
Herein we describe the synthesis
of a new heterodinuclear Fe<sup>III</sup>Cu<sup>II</sup> model complex
for the active site of purple acid phosphatases and its binding to
a polyamine chain, a model for the amino acid residues around the
active site. The properties of these systems and their catalytic activity
in the hydrolysis of bis(2,4-dinitrophenyl)phosphate are compared,
and conclusions regarding the effects of the second coordination sphere
are drawn. The positive effect of the polymeric chain on DNA hydrolysis
is also described and discussed
Second-Coordination-Sphere Effects Increase the Catalytic Efficiency of an Extended Model for Fe<sup>III</sup>M<sup>II</sup> Purple Acid Phosphatases
Herein we describe the synthesis
of a new heterodinuclear Fe<sup>III</sup>Cu<sup>II</sup> model complex
for the active site of purple acid phosphatases and its binding to
a polyamine chain, a model for the amino acid residues around the
active site. The properties of these systems and their catalytic activity
in the hydrolysis of bis(2,4-dinitrophenyl)phosphate are compared,
and conclusions regarding the effects of the second coordination sphere
are drawn. The positive effect of the polymeric chain on DNA hydrolysis
is also described and discussed